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Metaplasia

MedGen UID:
7571
Concept ID:
C0025568
Cell or Molecular Dysfunction
Synonym: Metaplastic Change
SNOMED CT: Metaplasia (17665002)

Definition

Transformation of a mature, normal cell or groups of mature cells to other forms of mature cells. The capacity for malignant transformation of metaplastic cells is a subject of controversy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetaplasia

Professional guidelines

PubMed

Amro B, Ramirez Aristondo ME, Alsuwaidi S, Almaamari B, Hakim Z, Tahlak M, Wattiez A, Koninckx PR
Int J Environ Res Public Health 2022 May 31;19(11) doi: 10.3390/ijerph19116725. PMID: 35682310Free PMC Article
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Vercellini P, Viganò P, Somigliana E, Fedele L
Nat Rev Endocrinol 2014 May;10(5):261-75. Epub 2013 Dec 24 doi: 10.1038/nrendo.2013.255. PMID: 24366116

Recent clinical studies

Etiology

Drnovsek J, Homan M, Zidar N, Smid LM
Radiol Oncol 2024 Jun 1;58(2):186-195. Epub 2024 Apr 21 doi: 10.2478/raon-2024-0028. PMID: 38643513Free PMC Article
Goldenring JR, Mills JC
Gastroenterology 2022 Feb;162(2):415-430. Epub 2021 Oct 30 doi: 10.1053/j.gastro.2021.10.036. PMID: 34728185Free PMC Article
Gupta S, Li D, El Serag HB, Davitkov P, Altayar O, Sultan S, Falck-Ytter Y, Mustafa RA
Gastroenterology 2020 Feb;158(3):693-702. Epub 2019 Dec 6 doi: 10.1053/j.gastro.2019.12.003. PMID: 31816298Free PMC Article
Bell C, Meara N, Gulur D, Middela S
BMJ Case Rep 2018 Aug 16;2018 doi: 10.1136/bcr-2018-225303. PMID: 30115715Free PMC Article
Meyer AR, Goldenring JR
J Physiol 2018 Sep;596(17):3861-3867. Epub 2018 Mar 24 doi: 10.1113/JP275512. PMID: 29427515Free PMC Article

Diagnosis

Goldenring JR, Mills JC
Gastroenterology 2022 Feb;162(2):415-430. Epub 2021 Oct 30 doi: 10.1053/j.gastro.2021.10.036. PMID: 34728185Free PMC Article
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Trieu JA, Bilal M, Saraireh H, Wang AY
Dig Dis Sci 2019 May;64(5):1079-1088. doi: 10.1007/s10620-019-05526-5. PMID: 30771043
Bell C, Meara N, Gulur D, Middela S
BMJ Case Rep 2018 Aug 16;2018 doi: 10.1136/bcr-2018-225303. PMID: 30115715Free PMC Article
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811

Therapy

Bouzid K, Sharma H, Killcoyne S, Castro DC, Schwaighofer A, Ilse M, Salvatelli V, Oktay O, Murthy S, Bordeaux L, Moore L, O'Donovan M, Thieme A, Nori A, Gehrung M, Alvarez-Valle J
Nat Commun 2024 Mar 11;15(1):2026. doi: 10.1038/s41467-024-46174-2. PMID: 38467600Free PMC Article
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Sung JJY, Coker OO, Chu E, Szeto CH, Luk STY, Lau HCH, Yu J
Gut 2020 Sep;69(9):1572-1580. Epub 2020 Jan 23 doi: 10.1136/gutjnl-2019-319826. PMID: 31974133Free PMC Article
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252

Prognosis

Huang RJ, Laszkowska M, In H, Hwang JH, Epplein M
Gastroenterology 2023 Apr;164(5):736-751. Epub 2023 Jan 24 doi: 10.1053/j.gastro.2023.01.018. PMID: 36706842Free PMC Article
Iyer PG, Kaul V
Mayo Clin Proc 2019 Sep;94(9):1888-1901. doi: 10.1016/j.mayocp.2019.01.032. PMID: 31486383
Venerito M, Link A, Rokkas T, Malfertheiner P
Helicobacter 2019 Sep;24 Suppl 1:e12643. doi: 10.1111/hel.12643. PMID: 31486238
den Hoed CM, Kuipers EJ
Curr Gastroenterol Rep 2016 Jul;18(7):34. doi: 10.1007/s11894-016-0506-0. PMID: 27184043Free PMC Article
Schouten WR
Mediators Inflamm 1998;7(3):175-81. doi: 10.1080/09629359891117. PMID: 9705605Free PMC Article

Clinical prediction guides

Bordin D, Livzan M
World J Gastroenterol 2024 Apr 7;30(13):1851-1858. doi: 10.3748/wjg.v30.i13.1851. PMID: 38659477Free PMC Article
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Toyoshima O, Nishizawa T, Koike K
World J Gastroenterol 2020 Feb 7;26(5):466-477. doi: 10.3748/wjg.v26.i5.466. PMID: 32089624Free PMC Article
Baraliakos X, Braun J
Rheum Dis Clin North Am 2016 Nov;42(4):663-678. doi: 10.1016/j.rdc.2016.07.006. PMID: 27742020
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent systematic reviews

Soroorikia S, Kazeminia M, Qaderi K, Ziapour A, Hodhodi T, Javanbakht Z
Syst Rev 2024 Sep 28;13(1):247. doi: 10.1186/s13643-024-02633-x. PMID: 39342409Free PMC Article
Altayar O, Davitkov P, Shah SC, Gawron AJ, Morgan DR, Turner K, Mustafa RA
Gastroenterology 2020 Feb;158(3):732-744.e16. Epub 2019 Dec 6 doi: 10.1053/j.gastro.2019.12.002. PMID: 31816301Free PMC Article
Gawron AJ, Shah SC, Altayar O, Davitkov P, Morgan D, Turner K, Mustafa RA
Gastroenterology 2020 Feb;158(3):705-731.e5. Epub 2019 Dec 6 doi: 10.1053/j.gastro.2019.12.001. PMID: 31816300Free PMC Article
Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, Greco P, Nappi L
Oxid Med Cell Longev 2017;2017:7265238. Epub 2017 Sep 19 doi: 10.1155/2017/7265238. PMID: 29057034Free PMC Article
Morais S, Rodrigues S, Amorim L, Peleteiro B, Lunet N
Dig Liver Dis 2014 Nov;46(11):1031-7. Epub 2014 Sep 5 doi: 10.1016/j.dld.2014.08.034. PMID: 25195087

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