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Apocrine adenocarcinoma

MedGen UID:
569650
Concept ID:
C0334346
Neoplastic Process
Synonyms: Apocrine Adenocarcinoma; apocrine adenocarcinoma; apocrine adenocarcinoma (morphologic abnormality); Apocrine Carcinoma; apocrine carcinoma; apocrine gland adenocarcinoma; Apocrine Gland Carcinoma; apocrine gland carcinoma; Carcinoma of Apocrine Gland; carcinoma of apocrine gland; carcinoma of the apocrine gland
SNOMED CT: Apocrine adenocarcinoma (57141000)
 
Monarch Initiative: MONDO:0003214

Definition

A carcinoma with apocrine differentiation arising from the sweat glands. It presents as single or multiple nodular lesions which may be ulcerated or hemorrhagic and is usually in the axilla and less often in the anogenital region. It grows in the dermis and infiltrates subcutaneous tissues. It is characterized by the presence of large cells with abundant eosinophilic cytoplasm and large often vesicular nuclei. Most cases are slow growing tumors and have a prolonged course. [from NCI]

Professional guidelines

PubMed

Tsuruta S, Ogata D, Namikawa K, Nakano E, Yamazaki N
Jpn J Clin Oncol 2024 Nov 2;54(11):1135-1140. doi: 10.1093/jjco/hyae103. PMID: 39079082
Koç İ, Kiratli H, Kapucu Y, Söylemezoğlu F
Eur J Ophthalmol 2022 May;32(3):1804-1809. Epub 2021 Jun 29 doi: 10.1177/11206721211029473. PMID: 34187188
Fernandez-Flores A
Acta Dermatovenerol Alp Pannonica Adriat 2009 Sep;18(3):141-2. PMID: 19784530

Recent clinical studies

Etiology

Tsuruta S, Ogata D, Namikawa K, Nakano E, Yamazaki N
Jpn J Clin Oncol 2024 Nov 2;54(11):1135-1140. doi: 10.1093/jjco/hyae103. PMID: 39079082
Koç İ, Kiratli H, Kapucu Y, Söylemezoğlu F
Eur J Ophthalmol 2022 May;32(3):1804-1809. Epub 2021 Jun 29 doi: 10.1177/11206721211029473. PMID: 34187188
Desouki MM, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):71-84. Epub 2020 Sep 25 doi: 10.1053/j.semdp.2020.09.011. PMID: 33032903
Otsuka M, Yamasaki O, Kaji T, Shien T, Iwatsuki K
JAMA Dermatol 2016 Jan;152(1):111-3. doi: 10.1001/jamadermatol.2015.2507. PMID: 26375389
Pornpanich K, Chindasub P
J Med Assoc Thai 2005 Nov;88 Suppl 9:S11-4. PMID: 16681045

Diagnosis

Tsuruta S, Ogata D, Namikawa K, Nakano E, Yamazaki N
Jpn J Clin Oncol 2024 Nov 2;54(11):1135-1140. doi: 10.1093/jjco/hyae103. PMID: 39079082
Koç İ, Kiratli H, Kapucu Y, Söylemezoğlu F
Eur J Ophthalmol 2022 May;32(3):1804-1809. Epub 2021 Jun 29 doi: 10.1177/11206721211029473. PMID: 34187188
Rosales Santillan M, Tschen JA, Soparkar CN
Dermatol Online J 2019 May 15;25(5) PMID: 31220897
Elefteriou-Kokolis E, Danielsen R, Kokolis RN
JAAPA 2018 Dec;31(12):27-28. doi: 10.1097/01.JAA.0000545067.78849.80. PMID: 30489387
Valenzuela AA, Cupp DG, Heathcote JG
Orbit 2012 Oct;31(5):316-8. Epub 2012 May 9 doi: 10.3109/01676830.2011.647378. PMID: 22571743

Therapy

Sola-Ortigosa J, Muñoz-Santos C, Hernández-Bronchud M, Guilabert-Vidal A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):973-975. Epub 2021 Nov 11 doi: 10.1016/j.ad.2021.04.010. PMID: 36460361
Hauer L, Gencur J, Posta P, Kasl Z, Rusnak S, Skalova A, Chalupova M, Liska J, Merglova V
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2022 Mar;166(1):117-125. Epub 2020 Nov 26 doi: 10.5507/bp.2020.051. PMID: 33252115
Elefteriou-Kokolis E, Danielsen R, Kokolis RN
JAAPA 2018 Dec;31(12):27-28. doi: 10.1097/01.JAA.0000545067.78849.80. PMID: 30489387
Otsuka M, Yamasaki O, Kaji T, Shien T, Iwatsuki K
JAMA Dermatol 2016 Jan;152(1):111-3. doi: 10.1001/jamadermatol.2015.2507. PMID: 26375389

Prognosis

Tsuruta S, Ogata D, Namikawa K, Nakano E, Yamazaki N
Jpn J Clin Oncol 2024 Nov 2;54(11):1135-1140. doi: 10.1093/jjco/hyae103. PMID: 39079082
Gibbs DC, Yeung H, Blalock TW
J Am Acad Dermatol 2023 Jan;88(1):226-228. Epub 2022 May 4 doi: 10.1016/j.jaad.2022.04.052. PMID: 35525505Free PMC Article
Otsuka M, Yamasaki O, Kaji T, Shien T, Iwatsuki K
JAMA Dermatol 2016 Jan;152(1):111-3. doi: 10.1001/jamadermatol.2015.2507. PMID: 26375389
Figueira EC, Danks J, Watanabe A, Khong JJ, Ong L, Selva D
Ophthalmic Plast Reconstr Surg 2013 Nov-Dec;29(6):417-23. doi: 10.1097/IOP.0b013e3182a64fe5. PMID: 24217473
Pornpanich K, Chindasub P
J Med Assoc Thai 2005 Nov;88 Suppl 9:S11-4. PMID: 16681045

Clinical prediction guides

Paiva F, Santos J, Carra G, Sueiro F, Jark P, Nardi A
Int J Mol Sci 2024 Jun 12;25(12) doi: 10.3390/ijms25126451. PMID: 38928157Free PMC Article
Arciero CA, Diehl AH 3rd, Liu Y, Sun Q, Gillespie T, Li X, Subhedar P
J Surg Oncol 2020 Nov;122(6):1232-1239. Epub 2020 Jul 15 doi: 10.1002/jso.26129. PMID: 32668059Free PMC Article
Unsal AA, Patel VR, Chung SY, Zhou AH, Baredes S, Eloy JA
Laryngoscope 2017 Dec;127(12):2757-2762. Epub 2017 Apr 11 doi: 10.1002/lary.26593. PMID: 28397272
Hollowell KL, Agle SC, Zervos EE, Fitzgerald TL
J Surg Oncol 2012 Mar 15;105(4):415-9. Epub 2011 Sep 12 doi: 10.1002/jso.22023. PMID: 21913192
Ansai S, Mitsuhashi Y, Kondo S, Manabe M
J Dermatol 2004 Dec;31(12):998-1008. doi: 10.1111/j.1346-8138.2004.tb00644.x. PMID: 15801265

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