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Sweat gland neoplasm

MedGen UID:
21039
•Concept ID:
C0038987
•
Neoplastic Process
Synonyms: Neoplasm, Sweat Gland; Neoplasms, Sweat Gland; Sweat Gland Neoplasm; Sweat Gland Neoplasms
SNOMED CT: Sweat gland tumor (12933008); Tumor of skin with eccrine differentiation (126490003); Neoplasm of sweat gland (126490003)
 
Monarch Initiative: MONDO:0002381

Definition

A benign or malignant neoplasm arising from the sweat glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSweat gland neoplasm

Professional guidelines

PubMed

CO(2) laser in the management of eccrine hidrocystomas: a retrospective study.
Fazia G, Cannarozzo G, Bennardo L, Nisticò SP
Lasers Med Sci 2022 Mar;37(2):1365-1369. Epub 2021 Sep 27 doi: 10.1007/s10103-021-03424-9. PMID: 34570293
The differential diagnosis of syringoma and milia based on the imaging of reflectance confocal microscopy.
Gao M, Lin Y, Wang L, Yu Y, Zhou Y, Chen S, Lu X, Shan X, Liu H
Skin Res Technol 2020 Nov;26(6):951-953. Epub 2020 Jun 14 doi: 10.1111/srt.12879. PMID: 32537748
A Modern Approach to Differential Diagnosis Between Cutaneous Apocrine Carcinoma and Metastasis From Breast Carcinoma.
Fernandez-Flores A
Am J Dermatopathol 2016 Feb;38(2):162-4. doi: 10.1097/DAD.0000000000000302. PMID: 26825162

Recent clinical studies

Etiology

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades.
Adefusika JA, Pimentel JD, Chavan RN, Brewer JD
Dermatol Surg 2015 Feb;41(2):201-8. doi: 10.1097/DSS.0000000000000198. PMID: 25627628
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Papillary eccrine adenoma in association with cutaneous horn.
Blasini W, Hu S, Gugic D, Vincek V
Am J Clin Dermatol 2007;8(3):179-82. doi: 10.2165/00128071-200708030-00005. PMID: 17492846
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
J Cutan Pathol 1987 Jun;14(3):129-46. doi: 10.1111/j.1600-0560.1987.tb00488.x. PMID: 3301927

Diagnosis

Digital Papillary Adenocarcinoma in Nonacral Skin: Clinicopathologic and Genetic Characterization of 5 Cases.
Kervarrec T, Imbeaud S, Veyer D, Pere H, Puech J, Pekár-Lukacs A, Markiewicz D, Coutts M, Tallet A, Collin C, Berthon P, Bravo IG, Seris A, Jouary T, Macagno N, Touzé A, Cribier B, Battistella M, Calonje E
Am J Surg Pathol 2023 Oct 1;47(10):1077-1084. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002096. PMID: 37505796
Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Poroid hidradenoma in a child: an unusual presentation.
López V, Santonja N, Calduch-Rodríguez L, Jordá E
Pediatr Dermatol 2011 Jan-Feb;28(1):60-1. doi: 10.1111/j.1525-1470.2010.01359.x. PMID: 21276058
Papillary eccrine adenoma in association with cutaneous horn.
Blasini W, Hu S, Gugic D, Vincek V
Am J Clin Dermatol 2007;8(3):179-82. doi: 10.2165/00128071-200708030-00005. PMID: 17492846
Mucinous syringometaplasia mimicked by a clear cell hidradenoma with mucinous change.
Hunt SJ, Abell E
J Cutan Pathol 1991 Oct;18(5):339-43. doi: 10.1111/j.1600-0560.1991.tb01546.x. PMID: 1662242

Therapy

Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature.
Kobayashi T, Hiura A, Oishi K, Maeda S, Le Pavoux AJ, Ohara K, Uruga H
Am J Dermatopathol 2016 Dec;38(12):910-914. doi: 10.1097/DAD.0000000000000703. PMID: 27870729Free PMC Article

Prognosis

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature.
Kobayashi T, Hiura A, Oishi K, Maeda S, Le Pavoux AJ, Ohara K, Uruga H
Am J Dermatopathol 2016 Dec;38(12):910-914. doi: 10.1097/DAD.0000000000000703. PMID: 27870729Free PMC Article
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40.
Paradela S, Castiñeiras I, Cuevas J, Almagro M, del Pozo J, Fonseca E
Am J Dermatopathol 2008 Oct;30(5):504-8. doi: 10.1097/DAD.0b013e318170c3cf. PMID: 18806501
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
J Cutan Pathol 1987 Jun;14(3):129-46. doi: 10.1111/j.1600-0560.1987.tb00488.x. PMID: 3301927

Clinical prediction guides

Primary cutaneous cribriform tumor: A case report and literature review.
Jiang D, Tian Y, Tian J, Liu H, Guan Y
J Cutan Pathol 2025 Jan;52(1):9-15. Epub 2024 Sep 23 doi: 10.1111/cup.14723. PMID: 39313825
An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature.
Rollins-Raval M, Chivukula M, Tseng GC, Jukic D, Dabbs DJ
Arch Pathol Lab Med 2011 Aug;135(8):975-83. doi: 10.5858/2009-0445-OAR2. PMID: 21809988
Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40.
Paradela S, Castiñeiras I, Cuevas J, Almagro M, del Pozo J, Fonseca E
Am J Dermatopathol 2008 Oct;30(5):504-8. doi: 10.1097/DAD.0b013e318170c3cf. PMID: 18806501
'Nuclear grooves' in nodular hidradenoma: frequency and significance of an unrecognized histopatological feature.
Khurshid A, Yaqoob N, Devan HA, Pervez S
J Cutan Pathol 2007 Nov;34(11):871-5. doi: 10.1111/j.1600-0560.2007.00743.x. PMID: 17944729
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations.
Kao GF, Helwig EB, Graham JH
J Cutan Pathol 1987 Jun;14(3):129-46. doi: 10.1111/j.1600-0560.1987.tb00488.x. PMID: 3301927

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