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Apocrine sweat gland neoplasm

MedGen UID:
272320
•Concept ID:
C1332318
•
Neoplastic Process
Synonyms: Apocrine Neoplasm; apocrine neoplasm; Apocrine Neoplasm of Skin; apocrine neoplasm of skin; Apocrine Neoplasm of the Skin; apocrine neoplasm of the skin; Apocrine Skin Neoplasm; apocrine skin neoplasm; Apocrine Skin Tumor; apocrine skin tumor; apocrine skin tumour; apocrine sweat gland neoplasm; apocrine sweat gland neoplasm (disease); apocrine sweat gland tumor; apocrine sweat gland tumour; Apocrine Tumor; apocrine tumor; Apocrine Tumor of Skin; apocrine tumor of skin; Apocrine Tumor of the Skin; apocrine tumor of the skin; apocrine tumour; apocrine tumour of skin; apocrine tumour of the skin; neoplasm of apocrine sweat gland; tumor of apocrine sweat gland; tumour of apocrine sweat gland
 
Monarch Initiative: MONDO:0003686

Definition

A benign or malignant sweat gland neoplasm with apocrine differentiation. Representative examples include apocrine adenoma, ceruminous adenocarcinoma, and apocrine breast carcinoma. [from NCI]

Professional guidelines

PubMed

Neo-adjuvant treatment in invasive apocrine carcinoma of the breast.
Altundag K
Breast J 2019 May;25(3):568. Epub 2019 Apr 13 doi: 10.1111/tbj.13285. PMID: 30980572
A Modern Approach to Differential Diagnosis Between Cutaneous Apocrine Carcinoma and Metastasis From Breast Carcinoma.
Fernandez-Flores A
Am J Dermatopathol 2016 Feb;38(2):162-4. doi: 10.1097/DAD.0000000000000302. PMID: 26825162
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation.
Fernandez-Flores A
Acta Dermatovenerol Alp Pannonica Adriat 2009 Sep;18(3):141-2. PMID: 19784530

Recent clinical studies

Etiology

Cutaneous Eccrine Carcinoma: A Retrospective Review of Epidemiologic Features and Clinical Outcomes.
Marous M, Scott G, Ibrahim SF
Dermatol Surg 2022 Oct 1;48(10):1115-1117. Epub 2022 Sep 2 doi: 10.1097/DSS.0000000000003588. PMID: 36095255
Squamoid Eccrine Ductal Carcinoma.
Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321
Squamoid Eccrine Ductal Carcinoma: The Scripps Experience.
Chow P, Goddard L, Greenway HT, Kelley BF
Dermatol Surg 2021 Aug 1;47(8):1115-1117. doi: 10.1097/DSS.0000000000002906. PMID: 34115678
Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
Squamoid eccrine ductal carcinoma of the scalp.
Chan H, Howard V, Moir D, Dyall-Smith D
Australas J Dermatol 2016 Aug;57(3):e117-9. Epub 2015 Mar 6 doi: 10.1111/ajd.12309. PMID: 25752474

Diagnosis

Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Syringoid eccrine carcinoma.
Abedi SM, Yu R, Salama S, Alowami S
Cutis 2015 Sep;96(3):162,191-2. PMID: 26562272
Epidermotropic eccrine porocarcinoma.
Landa NG, Winkelmann RK
J Am Acad Dermatol 1991 Jan;24(1):27-31. doi: 10.1016/0190-9622(91)70004-l. PMID: 1999525
Eccrine porocarcinoma.
Gschnait F, Horn F, Lindlbauer R, Sponer D
J Cutan Pathol 1980 Dec;7(6):349-53. doi: 10.1111/j.1600-0560.1980.tb01208.x. PMID: 6256417

Therapy

Gustatory Hyperhidrosis after Parotid Surgery.
Huang TR, Lee JC
N Engl J Med 2024 Sep 12;391(10):e21. Epub 2024 Sep 7 doi: 10.1056/NEJMicm2404232. PMID: 39248341
Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
Adult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene.
Alomran H, Kanitakis J
Dermatol Online J 2020 Feb 15;26(2) PMID: 32239895
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report.
Otsuka M, Yamasaki O, Kaji T, Shien T, Iwatsuki K
JAMA Dermatol 2016 Jan;152(1):111-3. doi: 10.1001/jamadermatol.2015.2507. PMID: 26375389
Olanzapine-induced eccrine squamous syringometaplasia.
Molina-Ruiz AM, Molina-Ruiz RM, Zulueta T, Barabash R, Requena L
Am J Dermatopathol 2012 Jun;34(4):434-7. doi: 10.1097/DAD.0b013e31823812f1. PMID: 22257902

Prognosis

Adnexal and Sebaceous Carcinomas.
Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972
Squamoid Eccrine Ductal Carcinoma: The Scripps Experience.
Chow P, Goddard L, Greenway HT, Kelley BF
Dermatol Surg 2021 Aug 1;47(8):1115-1117. doi: 10.1097/DSS.0000000000002906. PMID: 34115678
Sweat Gland Tumor Microenvironment.
Yuda Handaya A, Anwar SL, Fauzi AR, Werdana VAP
Adv Exp Med Biol 2020;1296:259-274. doi: 10.1007/978-3-030-59038-3_16. PMID: 34185298
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Malignant adnexal neoplasms.
Crowson AN, Magro CM, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S93-S126. doi: 10.1038/modpathol.3800511. PMID: 16446719

Clinical prediction guides

Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
(Reactive) Eccrine Syringofibroadenoma with Foci of Squamous Cell Carcinoma in situ: A Case Report.
Franin I, Regović Džombeta T, Krušlin B, Tomas D
Acta Dermatovenerol Croat 2021 Nov;29(4):224-227. PMID: 36896694
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Multiple eccrine hidrocystomas of the face.
Alfadley A, Al Aboud K, Tulba A, Mourad MM
Int J Dermatol 2001 Feb;40(2):125-9. doi: 10.1046/j.1365-4362.2001.01126.x. PMID: 11328394
Eccrine porocarcinoma.
Akiyoshi E, Nogita T, Yamaguchi R, Toyoda H, Kawashima M, Hidano A
Dermatologica 1991;182(4):239-42. doi: 10.1159/000247804. PMID: 1653154

Recent systematic reviews

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875

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