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Small cell lung carcinoma(SCCL)

MedGen UID:
57450
•Concept ID:
C0149925
•
Neoplastic Process
Synonyms: Lung oat cell carcinoma; SMALL CELL CANCER OF THE LUNG, SOMATIC; Small cell lung cancer
SNOMED CT: Small cell carcinoma of lung (254632001); SCLC - Small cell lung cancer (254632001); Small cell lung cancer (254632001); Oat cell carcinoma of lung (254632001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Gene (location): RB1 (13q14.2)
 
HPO: HP:0030357
Monarch Initiative: MONDO:0008433
OMIM®: 182280
Orphanet: ORPHA70573

Definition

Small cell lung cancer (SCLC) is a type of highly malignant lung cancer that is composed of small ovoid cells. In the past, SCLC was called oat cell carcinoma because the microscopic appearance of the cells was felt to resemble oats. SLCLC usually originates near the bronchi and in many cases may grow and metastasize quickly. [from HPO]

Clinical features

From HPO
Neoplasm of lung
MedGen UID:
7400
•Concept ID:
C0024121
•
Neoplastic Process
Tumor of the lung.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall cell lung carcinoma
Follow this link to review classifications for Small cell lung carcinoma in Orphanet.

Professional guidelines

PubMed

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Treatment of Brain Metastases of Non-Small Cell Lung Carcinoma.
Rybarczyk-Kasiuchnicz A, Ramlau R, Stencel K
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020593. PMID: 33435596Free PMC Article
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy.
Osmani L, Askin F, Gabrielson E, Li QK
Semin Cancer Biol 2018 Oct;52(Pt 1):103-109. Epub 2017 Nov 26 doi: 10.1016/j.semcancer.2017.11.019. PMID: 29183778Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Small Cell Lung Cancer, 2023

UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection.
Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387Free PMC Article
Radiotherapy for primary lung cancer.
Khalifa J, Lerouge D, Le Péchoux C, Pourel N, Darréon J, Mornex F, Giraud P
Cancer Radiother 2022 Feb-Apr;26(1-2):231-243. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.11.005. PMID: 34953709
Lung Cancer.
Lareau S, Slatore C, Smyth R
Am J Respir Crit Care Med 2021 Dec 15;204(12):P21-P22. doi: 10.1164/rccm.20411P21. PMID: 34908517
Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, Lantuejoul S, Peters S, Reguart N, Rudin CM, De Ruysscher D, Van Schil PE, Vansteenkiste J, Reck M; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Jul;32(7):839-853. Epub 2021 Apr 20 doi: 10.1016/j.annonc.2021.03.207. PMID: 33864941Free PMC Article
Lung Cancer OncoGuia.
Lung Cancer OncoGuia Group, Manchon Walsh P, Manchon P, Borràs JM, Ferro T, Espinàs JA
Clin Transl Oncol 2009 Dec;11(12):805-24. doi: 10.1007/s12094-009-0449-0. PMID: 20045787

Diagnosis

SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection.
Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387Free PMC Article
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Lung cancer.
Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS
Lancet 2021 Aug 7;398(10299):535-554. Epub 2021 Jul 21 doi: 10.1016/S0140-6736(21)00312-3. PMID: 34273294
Small cell lung cancer.
Nat Rev Dis Primers 2021 Jan 14;7(1):4. doi: 10.1038/s41572-021-00244-7. PMID: 33446659
Small-cell lung cancer.
van Meerbeeck JP, Fennell DA, De Ruysscher DK
Lancet 2011 Nov 12;378(9804):1741-55. Epub 2011 May 10 doi: 10.1016/S0140-6736(11)60165-7. PMID: 21565397

Therapy

Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer: The ASTRUM-005 Randomized Clinical Trial.
Cheng Y, Han L, Wu L, Chen J, Sun H, Wen G, Ji Y, Dvorkin M, Shi J, Pan Z, Shi J, Wang X, Bai Y, Melkadze T, Pan Y, Min X, Viguro M, Li X, Zhao Y, Yang J, Makharadze T, Arkania E, Kang W, Wang Q, Zhu J; ASTRUM-005 Study Group
JAMA 2022 Sep 27;328(12):1223-1232. doi: 10.1001/jama.2022.16464. PMID: 36166026Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Lurbinectedin: First Approval.
Markham A
Drugs 2020 Sep;80(13):1345-1353. doi: 10.1007/s40265-020-01374-0. PMID: 32816202
Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.
Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Shire N, Jiang H, Goldman JW; CASPIAN investigators
Lancet 2019 Nov 23;394(10212):1929-1939. Epub 2019 Oct 4 doi: 10.1016/S0140-6736(19)32222-6. PMID: 31590988
Emerging therapies for small cell lung cancer.
Yang S, Zhang Z, Wang Q
J Hematol Oncol 2019 May 2;12(1):47. doi: 10.1186/s13045-019-0736-3. PMID: 31046803Free PMC Article

Prognosis

Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆).
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, Lantuejoul S, Peters S, Reguart N, Rudin CM, De Ruysscher D, Van Schil PE, Vansteenkiste J, Reck M; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Jul;32(7):839-853. Epub 2021 Apr 20 doi: 10.1016/j.annonc.2021.03.207. PMID: 33864941Free PMC Article
High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial.
Grønberg BH, Killingberg KT, Fløtten Ø, Brustugun OT, Hornslien K, Madebo T, Langer SW, Schytte T, Nyman J, Risum S, Tsakonas G, Engleson J, Halvorsen TO
Lancet Oncol 2021 Mar;22(3):321-331. doi: 10.1016/S1470-2045(20)30742-7. PMID: 33662285
Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial.
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Advances in Small Cell Lung Cancer.
Kalemkerian GP, Schneider BJ
Hematol Oncol Clin North Am 2017 Feb;31(1):143-156. doi: 10.1016/j.hoc.2016.08.005. PMID: 27912830

Clinical prediction guides

An Autoantibody Subset Can Be Used for SCLC Early Detection.
Cancer Discov 2023 Mar 1;13(3):526. doi: 10.1158/2159-8290.CD-RW2023-009. PMID: 36661372
Emerging Strategies for the Treatment of Small Cell Lung Cancer: A Review.
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
The efficacy of music therapy to relieve pain, anxiety, and promote sleep quality, in patients with small cell lung cancer receiving platinum-based chemotherapy.
Tang H, Chen L, Wang Y, Zhang Y, Yang N, Yang N
Support Care Cancer 2021 Dec;29(12):7299-7306. Epub 2021 May 26 doi: 10.1007/s00520-021-06152-6. PMID: 34041615
Immunocytochemistry for predictive biomarker testing in lung cancer cytology.
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
Personalized oncology in interventional radiology.
Abi-Jaoudeh N, Duffy AG, Greten TF, Kohn EC, Clark TW, Wood BJ
J Vasc Interv Radiol 2013 Aug;24(8):1083-92; quiz 1093. doi: 10.1016/j.jvir.2013.04.019. PMID: 23885909Free PMC Article

Recent systematic reviews

Neoadjuvant Chemo-Immunotherapy for Early-Stage Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Banna GL, Hassan MA, Signori A, Giunta EF, Maniam A, Anpalakhan S, Acharige S, Ghose A, Addeo A
JAMA Netw Open 2024 Apr 1;7(4):e246837. doi: 10.1001/jamanetworkopen.2024.6837. PMID: 38625698Free PMC Article
Chemoimmunotherapy combined with consolidative thoracic radiotherapy for extensive-stage small cell lung cancer: A systematic review and meta-analysis.
Feng B, Zheng Y, Zhang J, Tang M, Na F
Radiother Oncol 2024 Jan;190:110014. Epub 2023 Nov 18 doi: 10.1016/j.radonc.2023.110014. PMID: 37981084
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Incidence of Pneumonitis With Use of Programmed Death 1 and Programmed Death-Ligand 1 Inhibitors in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Trials.
Khunger M, Rakshit S, Pasupuleti V, Hernandez AV, Mazzone P, Stevenson J, Pennell NA, Velcheti V
Chest 2017 Aug;152(2):271-281. Epub 2017 May 10 doi: 10.1016/j.chest.2017.04.177. PMID: 28499515
Evidence-based imaging in lung cancer: a systematic review.
Ravenel JG
J Thorac Imaging 2012 Sep;27(5):315-24. doi: 10.1097/RTI.0b013e318254a198. PMID: 22914125

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Small Cell Lung Cancer, 2023
    • NICE, 2023
      UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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