U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast carcinoma in situ

MedGen UID:
57817
•Concept ID:
C0154084
•
Neoplastic Process
Synonym: Breast Carcinoma In Situ
SNOMED CT: Carcinoma in situ of breast (189336000); Non-invasive carcinoma of breast (189336000)
 
Monarch Initiative: MONDO:0004658

Definition

A in situ carcinoma that involves the breast. [from MONDO]

Professional guidelines

PubMed

In situ breast carcinoma: diagnosis and treatment.
Hindle WH
Clin Obstet Gynecol 2002 Sep;45(3):774-7. doi: 10.1097/00003081-200209000-00025. PMID: 12370620
Management of in situ and minimally invasive breast carcinoma.
Frykberg ER, Bland KI
World J Surg 1994 Jan-Feb;18(1):45-57. doi: 10.1007/BF00348191. PMID: 8197776
The treatment of in situ breast cancer.
Fentiman IS
Acta Oncol 1989;28(6):923-6. doi: 10.3109/02841868909092333. PMID: 2558695

Recent clinical studies

Etiology

Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article
Clinical and pathological assessment of high-risk ductal and lobular breast lesions: What surgeons must know.
Mastropasqua MG, Viale G
Eur J Surg Oncol 2017 Feb;43(2):278-284. Epub 2016 Aug 5 doi: 10.1016/j.ejso.2016.07.011. PMID: 27544280
Cancer statistics: Breast cancer in situ.
Ward EM, DeSantis CE, Lin CC, Kramer JL, Jemal A, Kohler B, Brawley OW, Gansler T
CA Cancer J Clin 2015 Nov-Dec;65(6):481-95. Epub 2015 Oct 2 doi: 10.3322/caac.21321. PMID: 26431342

Diagnosis

Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Overview of breast cancer.
Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article
Cancer statistics: Breast cancer in situ.
Ward EM, DeSantis CE, Lin CC, Kramer JL, Jemal A, Kohler B, Brawley OW, Gansler T
CA Cancer J Clin 2015 Nov-Dec;65(6):481-95. Epub 2015 Oct 2 doi: 10.3322/caac.21321. PMID: 26431342

Therapy

Comparing Breast Cancer and Cardiovascular Disease Risk and Use of Chemoprevention and Statins among Women with High-risk Breast Lesions.
Lawal KO, Nilan L, Amenta J, McGuinness JE, Kukafka R, Crew KD
Cancer Prev Res (Phila) 2023 Dec 1;16(12):661-667. doi: 10.1158/1940-6207.CAPR-23-0181. PMID: 37976537Free PMC Article
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Treatment Outcomes for Pleomorphic Lobular Carcinoma In Situ of the Breast.
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004
Overdiagnosis in breast imaging.
Evans A, Vinnicombe S
Breast 2017 Feb;31:270-273. Epub 2016 Oct 28 doi: 10.1016/j.breast.2016.10.011. PMID: 28029492
Postmenopausal hormone therapy and ductal carcinoma in situ: a population-based case-control study.
Calvocoressi L, Stowe MH, Carter D, Claus EB
Cancer Epidemiol 2012 Apr;36(2):161-8. Epub 2012 Feb 6 doi: 10.1016/j.canep.2012.01.001. PMID: 22317899Free PMC Article

Prognosis

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Breast carcinoma in situ: An observational study of tumor subtype, treatment and outcomes.
Wu Q, Li J, Sun S, Zhu S, Chen C, Wu J, Liu Q, Wei W, Sun S
Oncotarget 2017 Jan 10;8(2):2361-2371. doi: 10.18632/oncotarget.13785. PMID: 27926499Free PMC Article
Cause-specific mortality in women with breast cancer in situ.
He W, Sofie Lindström L, Hall P, Czene K
Int J Cancer 2017 Jun 1;140(11):2414-2421. Epub 2016 Sep 19 doi: 10.1002/ijc.30413. PMID: 27594272
Cancer statistics: Breast cancer in situ.
Ward EM, DeSantis CE, Lin CC, Kramer JL, Jemal A, Kohler B, Brawley OW, Gansler T
CA Cancer J Clin 2015 Nov-Dec;65(6):481-95. Epub 2015 Oct 2 doi: 10.3322/caac.21321. PMID: 26431342
Breast carcinoma in situ.
Kinne DW, Petrek JA, Osborne MP, Fracchia AA, DePalo AA, Rosen PP
Arch Surg 1989 Jan;124(1):33-6. doi: 10.1001/archsurg.1989.01410010039008. PMID: 2535929

Clinical prediction guides

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Pleomorphic Lobular Carcinoma In Situ: Imaging Features, Upgrade Rate, and Clinical Outcomes.
Savage JL, Jeffries DO, Noroozian M, Sabel MS, Jorns JM, Helvie MA
AJR Am J Roentgenol 2018 Aug;211(2):462-467. Epub 2018 Jun 12 doi: 10.2214/AJR.17.19088. PMID: 29894223
Cause-specific mortality in women with breast cancer in situ.
He W, Sofie Lindström L, Hall P, Czene K
Int J Cancer 2017 Jun 1;140(11):2414-2421. Epub 2016 Sep 19 doi: 10.1002/ijc.30413. PMID: 27594272
Clonal relationships between lobular carcinoma in situ and other breast malignancies.
Begg CB, Ostrovnaya I, Carniello JV, Sakr RA, Giri D, Towers R, Schizas M, De Brot M, Andrade VP, Mauguen A, Seshan VE, King TA
Breast Cancer Res 2016 Jun 23;18(1):66. doi: 10.1186/s13058-016-0727-z. PMID: 27334989Free PMC Article

Recent systematic reviews

Atypical ductal or lobular hyperplasia, lobular carcinoma in-situ, flat epithelial atypia, and future risk of developing breast cancer: Systematic review and meta-analysis.
Baker J, Noguchi N, Marinovich ML, Sprague BL, Salisbury E, Houssami N
Breast 2024 Dec;78:103807. Epub 2024 Sep 11 doi: 10.1016/j.breast.2024.103807. PMID: 39270543Free PMC Article
The natural history of ductal carcinoma in situ (DCIS) in simulation models: A systematic review.
Poelhekken K, Lin Y, Greuter MJW, van der Vegt B, Dorrius M, de Bock GH
Breast 2023 Oct;71:74-81. Epub 2023 Jul 27 doi: 10.1016/j.breast.2023.07.012. PMID: 37541171Free PMC Article
Intercepting Premalignant, Preinvasive Breast Lesions Through Vaccination.
Zachariah NN, Basu A, Gautam N, Ramamoorthi G, Kodumudi KN, Kumar NB, Loftus L, Czerniecki BJ
Front Immunol 2021;12:786286. Epub 2021 Nov 24 doi: 10.3389/fimmu.2021.786286. PMID: 34899753Free PMC Article
Impact of lobular carcinoma in situ on local recurrence in breast cancer treated with breast conservation therapy: a systematic review and meta-analysis.
Harris CG, Eslick GD
ANZ J Surg 2021 Sep;91(9):1696-1703. Epub 2021 Feb 26 doi: 10.1111/ans.16671. PMID: 33634956

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...