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Acinar cell carcinoma

MedGen UID:
61660
•Concept ID:
C0206685
•
Neoplastic Process
Synonyms: Acinar Carcinoma; Acinar Carcinomas; Acinar Cell Adenocarcinoma; Acinar Cell Adenocarcinomas; Acinar Cell Carcinoma; Acinar Cell Carcinomas; Acinic Cell Adenocarcinoma; Acinic Cell Adenocarcinomas; Acinic Cell Carcinoma; Acinic Cell Carcinomas; Acinic Cell Tumor; Acinic Cell Tumors; Adenocarcinoma, Acinar Cell; Adenocarcinoma, Acinic Cell; Adenocarcinomas, Acinar Cell; Adenocarcinomas, Acinic Cell; Carcinoma, Acinar; Carcinoma, Acinar Cell; Carcinoma, Acinic Cell; Carcinomas, Acinar; Carcinomas, Acinar Cell; Carcinomas, Acinic Cell; Tumor, Acinic Cell; Tumors, Acinic Cell
SNOMED CT: Acinar cell carcinoma (45410002); Acinic cell adenocarcinoma (45410002); Acinar adenocarcinoma (45410002); Acinar carcinoma (45410002)
 
Monarch Initiative: MONDO:0004965

Definition

A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. [from NCI]

Professional guidelines

PubMed

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Current diagnosis and management of unusual pancreatic tumors.
Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB
Am J Surg 2008 Jul;196(1):100-13. Epub 2008 May 7 doi: 10.1016/j.amjsurg.2008.02.005. PMID: 18466869

Recent clinical studies

Etiology

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Non-Ductal Tumors of the Pancreas.
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article
Acinar neoplasms of the pancreas-A summary of 25 years of research.
Klimstra DS, Adsay V
Semin Diagn Pathol 2016 Sep;33(5):307-18. Epub 2016 May 13 doi: 10.1053/j.semdp.2016.05.009. PMID: 27320062
Acinic cell carcinoma of the salivary glands: a literature review.
Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS
Hematol Oncol Stem Cell Ther 2009;2(1):259-64. doi: 10.1016/s1658-3876(09)50035-0. PMID: 20063555

Diagnosis

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
Acinar cell carcinoma of the pancreas: a clinicopathologic and cytomorphologic review.
Mustafa S, Hruban RH, Ali SZ
J Am Soc Cytopathol 2020 Nov-Dec;9(6):586-595. Epub 2020 Apr 25 doi: 10.1016/j.jasc.2020.04.005. PMID: 32461075
Nonductal Pancreatic Cancers.
Jun SY, Hong SM
Surg Pathol Clin 2016 Dec;9(4):581-593. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.005. PMID: 27926361
Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms.
Wöll S, Schlitter AM, Dhaene K, Roller M, Esposito I, Sahin U, Türeci Ö
Int J Cancer 2014 Feb 1;134(3):731-9. Epub 2013 Sep 16 doi: 10.1002/ijc.28400. PMID: 23900716
Acinic cell carcinoma of the salivary glands: a literature review.
Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS
Hematol Oncol Stem Cell Ther 2009;2(1):259-64. doi: 10.1016/s1658-3876(09)50035-0. PMID: 20063555

Therapy

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature.
Busch E, Werft W, Bougatf N, Hackert T, Jäger D, Springfeld C, Berger AK
Pancreas 2021 Mar 1;50(3):300-305. doi: 10.1097/MPA.0000000000001765. PMID: 33835959
Robot-assisted combined pancreatectomy/hepatectomy for metastatic pancreatic acinar cell carcinoma: case report and review of the literature.
Villano AM, Barrak D, Jain A, Meslar E, Radkani P, Chalhoub W, Haddad N, Winslow E, Fishbein T, Hawksworth J
Clin J Gastroenterol 2020 Oct;13(5):973-980. Epub 2020 Jun 25 doi: 10.1007/s12328-020-01146-z. PMID: 32583372
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Prognosis

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Pancreatic acinar cell carcinoma-case report and literature review.
Xing-Mao Z, Hong-Juan Z, Qing L, Qiang H
BMC Cancer 2018 Nov 8;18(1):1083. doi: 10.1186/s12885-018-5008-z. PMID: 30409114Free PMC Article
Pancreatic Panniculitis and Polyarthritis.
Zundler S, Strobel D, Manger B, Neurath MF, Wildner D
Curr Rheumatol Rep 2017 Aug 26;19(10):62. doi: 10.1007/s11926-017-0690-4. PMID: 28844095
Salivary acinic cell carcinoma: reappraisal and update.
Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679

Clinical prediction guides

Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma.
Sun T, Gilani S, Jain D, Cai G
Diagn Cytopathol 2023 Nov;51(11):674-683. Epub 2023 Jul 19 doi: 10.1002/dc.25196. PMID: 37469257
Patients With Acinar Cell Carcinoma of the Pancreas After 2005: A Large Population Study.
Zong Y, Qi C, Peng Z, Shen L, Zhou J
Pancreas 2020 Jul;49(6):781-787. doi: 10.1097/MPA.0000000000001573. PMID: 32541633
Pancreatic acinar cell carcinoma-case report and literature review.
Xing-Mao Z, Hong-Juan Z, Qing L, Qiang H
BMC Cancer 2018 Nov 8;18(1):1083. doi: 10.1186/s12885-018-5008-z. PMID: 30409114Free PMC Article
High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate.
Zhou M
Mod Pathol 2018 Jan;31(S1):S71-79. doi: 10.1038/modpathol.2017.138. PMID: 29297491
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Recent systematic reviews

DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis.
Fiorentino V, Straccia P, Tralongo P, Musarra T, Pierconti F, Martini M, Fadda G, Rossi ED, Larocca LM
Int J Mol Sci 2022 Aug 26;23(17) doi: 10.3390/ijms23179711. PMID: 36077107Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas.
Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, Pimiento JM, Springett GM, Malafa MP
Cancer Control 2016 Oct;23(4):446-454. doi: 10.1177/107327481602300417. PMID: 27842335

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