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Acinar cell carcinoma

MedGen UID:
61660
•Concept ID:
C0206685
•
Neoplastic Process
Synonyms: Acinar Carcinoma; Acinar Carcinomas; Acinar Cell Adenocarcinoma; Acinar Cell Adenocarcinomas; Acinar Cell Carcinoma; Acinar Cell Carcinomas; Acinic Cell Adenocarcinoma; Acinic Cell Adenocarcinomas; Acinic Cell Carcinoma; Acinic Cell Carcinomas; Acinic Cell Tumor; Acinic Cell Tumors; Adenocarcinoma, Acinar Cell; Adenocarcinoma, Acinic Cell; Adenocarcinomas, Acinar Cell; Adenocarcinomas, Acinic Cell; Carcinoma, Acinar; Carcinoma, Acinar Cell; Carcinoma, Acinic Cell; Carcinomas, Acinar; Carcinomas, Acinar Cell; Carcinomas, Acinic Cell; Tumor, Acinic Cell; Tumors, Acinic Cell
SNOMED CT: Acinar cell carcinoma (45410002); Acinic cell adenocarcinoma (45410002); Acinar adenocarcinoma (45410002); Acinar carcinoma (45410002)
 
Monarch Initiative: MONDO:0004965

Definition

A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. [from NCI]

Professional guidelines

PubMed

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Prognostic Assessment and Risk Stratification in Patients With Postoperative Major Salivary Acinar Cell Carcinoma.
Zhang D, Wei Y, Chai Y, Qi F, Dong M
Otolaryngol Head Neck Surg 2023 May;168(5):1119-1129. Epub 2023 Jan 22 doi: 10.1002/ohn.195. PMID: 36939406

Recent clinical studies

Etiology

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Prostate cancer grading: a decade after the 2005 modified system.
Epstein JI
Mod Pathol 2018 Jan;31(S1):S47-63. doi: 10.1038/modpathol.2017.133. PMID: 29297487
Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review.
Butturini G, Pisano M, Scarpa A, D'Onofrio M, Auriemma A, Bassi C
Langenbecks Arch Surg 2011 Mar;396(3):363-9. Epub 2010 Aug 28 doi: 10.1007/s00423-010-0706-2. PMID: 20803029
Acinic cell carcinoma of the salivary glands: a literature review.
Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS
Hematol Oncol Stem Cell Ther 2009;2(1):259-64. doi: 10.1016/s1658-3876(09)50035-0. PMID: 20063555

Diagnosis

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
Heterotopic acinic cell carcinoma and its clinical implications.
Starek I, Salzman R, Skalova A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Mar;165(1):13-18. Epub 2020 Nov 12 doi: 10.5507/bp.2020.047. PMID: 33177745
The genetic classification of pancreatic neoplasia.
Matthaei H, Semaan A, Hruban RH
J Gastroenterol 2015 May;50(5):520-32. Epub 2015 Jan 21 doi: 10.1007/s00535-015-1037-4. PMID: 25605630
Acinic cell carcinoma of the salivary glands: a literature review.
Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS
Hematol Oncol Stem Cell Ther 2009;2(1):259-64. doi: 10.1016/s1658-3876(09)50035-0. PMID: 20063555

Therapy

Complete pathological response to pembrolizumab in pretreated pancreatic acinar cell carcinoma.
Merz V, Maines F, Marcucci S, Sartori C, Frisinghelli M, Trentin C, Kadrija D, Carbone FG, Michielan A, Gabbrielli A, Melisi D, Barbareschi M, Brolese A, Caffo O
J Cancer Res Clin Oncol 2024 Jul 11;150(7):347. doi: 10.1007/s00432-024-05841-z. PMID: 38990367Free PMC Article
DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Exceptional Clinical Response to Alectinib in Pancreatic Acinar Cell Carcinoma With a Novel ALK-KANK4 Gene Fusion.
Gaule M, Pesoni C, Quinzii A, Zecchetto C, Casalino S, Merz V, Contarelli S, Pietrobono S, Vissio E, Molinaro L, Manzin E, Volpatto R, Vellani G, Melisi D
JCO Precis Oncol 2022 Jan;6:e2100400. doi: 10.1200/PO.21.00400. PMID: 35005993Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Prognosis

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Heterotopic acinic cell carcinoma and its clinical implications.
Starek I, Salzman R, Skalova A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Mar;165(1):13-18. Epub 2020 Nov 12 doi: 10.5507/bp.2020.047. PMID: 33177745
Pancreatic acinar cell carcinoma.
Gravante G, Williams RN, Dennison AR, Bowrey DJ
Surgery 2012 Jul;152(1):138-9. Epub 2011 Oct 6 doi: 10.1016/j.surg.2011.07.024. PMID: 21982066

Clinical prediction guides

ABCD1 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm of the Pancreas.
Liu YA, Liu Y, Tu J, Shi Y, Pang J, Huang Q, Wang X, Lin Z, Zhao Y, Wang W, Peng J, Wu W
Am J Surg Pathol 2024 May 1;48(5):511-520. Epub 2024 Apr 3 doi: 10.1097/PAS.0000000000002205. PMID: 38567813Free PMC Article
DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma.
Sun T, Gilani S, Jain D, Cai G
Diagn Cytopathol 2023 Nov;51(11):674-683. Epub 2023 Jul 19 doi: 10.1002/dc.25196. PMID: 37469257
Microsatellite instability in pancreatic and ampullary carcinomas: histology, molecular pathology, and clinical implications.
Luchini C, Scarpa A
Hum Pathol 2023 Feb;132:176-182. Epub 2022 Jun 14 doi: 10.1016/j.humpath.2022.06.009. PMID: 35714836
CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas.
Lawlor RT, Daprà V, Girolami I, Pea A, Pilati C, Nottegar A, Piccoli P, Parolini C, Sperandio N, Capelli P, Scarpa A, Luchini C
Virchows Arch 2019 Jan;474(1):105-109. Epub 2018 Aug 21 doi: 10.1007/s00428-018-2437-7. PMID: 30132130Free PMC Article

Recent systematic reviews

DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis.
Fiorentino V, Straccia P, Tralongo P, Musarra T, Pierconti F, Martini M, Fadda G, Rossi ED, Larocca LM
Int J Mol Sci 2022 Aug 26;23(17) doi: 10.3390/ijms23179711. PMID: 36077107Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas.
Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, Pimiento JM, Springett GM, Malafa MP
Cancer Control 2016 Oct;23(4):446-454. doi: 10.1177/107327481602300417. PMID: 27842335

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