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Salivary gland acinic cell carcinoma

MedGen UID:
79030
•Concept ID:
C0279738
•
Neoplastic Process
Synonyms: Acinic Cell Carcinoma of Salivary Gland; acinic cell carcinoma of salivary gland; Acinic Cell Carcinoma of the Salivary Gland; acinic cell carcinoma of the salivary gland; Acinic Cell Neoplasm of Salivary Gland; acinic cell neoplasm of salivary gland; Acinic Cell Neoplasm of the Salivary Gland; acinic cell neoplasm of the salivary gland; Acinic Cell Tumor of Salivary Gland; acinic cell tumor of salivary gland; Acinic Cell Tumor of the Salivary Gland; acinic cell tumor of the salivary gland; acinic cell tumour of salivary gland; acinic cell tumour of the salivary gland; salivary gland acinic cell cancer; Salivary Gland Acinic Cell Carcinoma; salivary gland acinic cell carcinoma; Salivary Gland Acinic Cell Neoplasm; salivary gland acinic cell neoplasm; Salivary Gland Acinic Cell Tumor; salivary gland acinic cell tumor; salivary gland acinic cell tumour
 
Monarch Initiative: MONDO:0006400

Definition

A carcinoma of the salivary gland characterized by serous acinar cell differentiation. The vast majority of cases occur in the parotid gland. It usually presents as a slowly enlarging mass. A minority of patients experience pain. It may recur or metastasize. Multiple recurrences and metastasis to cervical lymph nodes are usually associated with a poor prognosis. [from NCI]

Professional guidelines

PubMed

P63 expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinomas.
Sams RN, Gnepp DR
Head Neck Pathol 2013 Mar;7(1):64-8. Epub 2012 Oct 10 doi: 10.1007/s12105-012-0403-2. PMID: 23054955Free PMC Article

Recent clinical studies

Etiology

NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.
Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T
Am J Clin Pathol 2022 Jan 6;157(1):98-108. doi: 10.1093/ajcp/aqab099. PMID: 34508546Free PMC Article
Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
Wang C, Mao M, Li B, Kim K, Han Z, Feng Z
J Oral Maxillofac Surg 2019 Aug;77(8):1713-1723. Epub 2019 Feb 5 doi: 10.1016/j.joms.2019.01.044. PMID: 30825434
Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.
Haller F, Bieg M, Will R, Körner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bähr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S, Agaimy A
Nat Commun 2019 Jan 21;10(1):368. doi: 10.1038/s41467-018-08069-x. PMID: 30664630Free PMC Article
Solid blue dot tumour: minor salivary gland acinic cell carcinoma.
Bavle RM, Makarla S, Nadaf A, Narasimhamurthy S
BMJ Case Rep 2014 Jun 13;2014 doi: 10.1136/bcr-2013-200885. PMID: 24928927Free PMC Article
Morphometric analysis using automated image analysis of CD34-positive vessels in salivary gland acinic cell carcinoma.
Luukkaa H, Laitakari J, Vahlberg T, Klemi P, Grénman R
Acta Otolaryngol 2007 Aug;127(8):869-73. doi: 10.1080/00016480601053099. PMID: 17763000

Diagnosis

NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.
Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T
Am J Clin Pathol 2022 Jan 6;157(1):98-108. doi: 10.1093/ajcp/aqab099. PMID: 34508546Free PMC Article
Perithyroidal Salivary Gland Acinic Cell Carcinoma: Morphological and Molecular Attributes of a Unique Lesion.
Juhlin CC, Asa SL, Jatta K, Naserhojati Rodsari H, Shabo I, Haglund F, Delahunt B, Samaratunga H, Egevad L, Höög A, Zedenius J
Head Neck Pathol 2021 Jun;15(2):628-637. Epub 2020 Jun 9 doi: 10.1007/s12105-020-01187-3. PMID: 32519264Free PMC Article
Minor Salivary Gland Acinic Cell Carcinoma With Orbital Extension.
Neren A, Reich I, Torno R, Shinder R
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S66-S68. doi: 10.1097/IOP.0000000000000514. PMID: 26068556
High grade transformation of salivary gland acinic cell carcinoma with emphasis on histological diagnosis and clinical implications.
Bury D, Dafalla M, Ahmed S, Hellquist H
Pathol Res Pract 2016 Nov;212(11):1059-1063. Epub 2016 Aug 22 doi: 10.1016/j.prp.2016.08.005. PMID: 27623207
Searching for mammary analogue [corrected] secretory carcinoma of salivary gland among its mimics.
Pinto A, Nosé V, Rojas C, Fan YS, Gomez-Fernandez C
Mod Pathol 2014 Jan;27(1):30-7. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.84. PMID: 23807775

Prognosis

NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.
Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T
Am J Clin Pathol 2022 Jan 6;157(1):98-108. doi: 10.1093/ajcp/aqab099. PMID: 34508546Free PMC Article
Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
Wang C, Mao M, Li B, Kim K, Han Z, Feng Z
J Oral Maxillofac Surg 2019 Aug;77(8):1713-1723. Epub 2019 Feb 5 doi: 10.1016/j.joms.2019.01.044. PMID: 30825434
High grade transformation of salivary gland acinic cell carcinoma with emphasis on histological diagnosis and clinical implications.
Bury D, Dafalla M, Ahmed S, Hellquist H
Pathol Res Pract 2016 Nov;212(11):1059-1063. Epub 2016 Aug 22 doi: 10.1016/j.prp.2016.08.005. PMID: 27623207
Searching for mammary analogue [corrected] secretory carcinoma of salivary gland among its mimics.
Pinto A, Nosé V, Rojas C, Fan YS, Gomez-Fernandez C
Mod Pathol 2014 Jan;27(1):30-7. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.84. PMID: 23807775
Morphometric analysis using automated image analysis of CD34-positive vessels in salivary gland acinic cell carcinoma.
Luukkaa H, Laitakari J, Vahlberg T, Klemi P, Grénman R
Acta Otolaryngol 2007 Aug;127(8):869-73. doi: 10.1080/00016480601053099. PMID: 17763000

Clinical prediction guides

NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens.
Viswanathan K, Beg S, He B, Zhang T, Cantley R, Lubin DJ, Shi Q, Maleki Z, Asiry S, Rao R, Katabi N, Nakaguro M, Faquin WC, Sadow PM, Siddiqui MT, Scognamiglio T
Am J Clin Pathol 2022 Jan 6;157(1):98-108. doi: 10.1093/ajcp/aqab099. PMID: 34508546Free PMC Article
Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
Wang C, Mao M, Li B, Kim K, Han Z, Feng Z
J Oral Maxillofac Surg 2019 Aug;77(8):1713-1723. Epub 2019 Feb 5 doi: 10.1016/j.joms.2019.01.044. PMID: 30825434
Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma.
Barasch N, Gong X, Kwei KA, Varma S, Biscocho J, Qu K, Xiao N, Lipsick JS, Pelham RJ, West RB, Pollack JR
PLoS One 2017;12(2):e0171265. Epub 2017 Feb 17 doi: 10.1371/journal.pone.0171265. PMID: 28212443Free PMC Article
Immunohistochemical expression of cytokeratins in human salivary gland acinic cell carcinomas.
Li X, Shi Z, Wang Y, Liu Y, Liu T
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Aug;120(2):248-57. Epub 2015 May 13 doi: 10.1016/j.oooo.2015.04.014. PMID: 26166029
Searching for mammary analogue [corrected] secretory carcinoma of salivary gland among its mimics.
Pinto A, Nosé V, Rojas C, Fan YS, Gomez-Fernandez C
Mod Pathol 2014 Jan;27(1):30-7. Epub 2013 Jun 28 doi: 10.1038/modpathol.2013.84. PMID: 23807775

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