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Testicular sex cord-stromal neoplasm

MedGen UID:
825921
Concept ID:
C3840076
Neoplastic Process
Synonym: Sex cord-stromal tumor of testis
SNOMED CT: Sex cord stromal tumor of testis of uncertain behavior (702406000)
 
Monarch Initiative: MONDO:0003125
Orphanet: ORPHA363489

Definition

A group of rare tumors of testis comprising neoplasms of pure sex cord or pure stromal type, or neoplasms with admixtures of both components in various proportions and degree of differentiation. The tumors usually present as a painless testicular mass, although some may be associated with endocrine manifestations such as precocious puberty, gynecomastia, or erectile dysfunction. Malignant behavior is seen only in a small percentage of these tumors. [from ORDO]

Professional guidelines

PubMed

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235
Hendrick JW, Bohne AW
South Med J 1971 Jul;64(7):873-81. doi: 10.1097/00007611-197107000-00021. PMID: 4397418

Recent clinical studies

Etiology

Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Wu HY, Snyder HM 3rd
Urol Clin North Am 2004 Aug;31(3):619-27, xi. doi: 10.1016/j.ucl.2004.04.004. PMID: 15313070
Mati W, Lam G, Dahl C, Thorup Andersen J, Balslev E
Int Urol Nephrol 2002;33(1):103-5. doi: 10.1023/a:1014481609336. PMID: 12090313
Young RH, Talerman A
Semin Diagn Pathol 1987 Nov;4(4):342-60. PMID: 2832918

Diagnosis

Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746
Markland C
Curr Probl Surg 1968 Sep:3-51. doi: 10.1016/s0011-3840(68)80001-2. PMID: 4386486

Therapy

Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235
Seifer DB, Maclaughlin DT
Fertil Steril 2007 Sep;88(3):539-46. Epub 2007 Jun 7 doi: 10.1016/j.fertnstert.2007.02.014. PMID: 17559842
Bertram KA, Bratloff B, Hodges GF, Davidson H
Cancer 1991 Nov 15;68(10):2324-9. doi: 10.1002/1097-0142(19911115)68:10<2324::aid-cncr2820681036>3.0.co;2-k. PMID: 1913469
Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Prognosis

Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Colecchia M, Nistal M, Gonzalez-Peramato P, Carmignani L, Salvioni R, Nicolai N, Regadera J
Anal Quant Cytol Histol 2007 Jun;29(3):139-47. PMID: 17672373
Al-Agha OM, Axiotis CA
Arch Pathol Lab Med 2007 Feb;131(2):311-7. doi: 10.5858/2007-131-311-AILALC. PMID: 17284120
Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Clinical prediction guides

Kotula-Balak M, Duliban M, Gurgul A, Krakowska I, Grzmil P, Bilinska B, Wolski JK
Andrologia 2021 Dec;53(11):e14222. Epub 2021 Sep 8 doi: 10.1111/and.14222. PMID: 34494678
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560Free PMC Article
Colecchia M, Nistal M, Gonzalez-Peramato P, Carmignani L, Salvioni R, Nicolai N, Regadera J
Anal Quant Cytol Histol 2007 Jun;29(3):139-47. PMID: 17672373
Seifer DB, Maclaughlin DT
Fertil Steril 2007 Sep;88(3):539-46. Epub 2007 Jun 7 doi: 10.1016/j.fertnstert.2007.02.014. PMID: 17559842

Recent systematic reviews

Bois JI, Vagni RL, de Badiola FI, Moldes JM, Losty PD, Lobos PA
Pediatr Surg Int 2021 May;37(5):607-616. Epub 2021 Jan 17 doi: 10.1007/s00383-020-04850-6. PMID: 33454815
Renne SL, Valeri M, Tosoni A, Bertolotti A, Rossi R, Renne G, Colecchia M
Virchows Arch 2021 Apr;478(4):727-734. Epub 2020 Nov 2 doi: 10.1007/s00428-020-02957-8. PMID: 33140129
Grogg JB, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Beyer J, Lorch A, Hermanns T, Fankhauser CD
J Cancer Res Clin Oncol 2020 Nov;146(11):2829-2841. Epub 2020 Jul 27 doi: 10.1007/s00432-020-03326-3. PMID: 32719989Free PMC Article
Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD
Oncologist 2020 Jul;25(7):585-590. Epub 2020 Feb 11 doi: 10.1634/theoncologist.2019-0692. PMID: 32043680Free PMC Article
Bozzini G, Ratti D, Carmignani L; en representación de Young Academic Urologists (YAU) Men's Health Group
Actas Urol Esp 2017 Apr;41(3):146-154. Epub 2016 Nov 25 doi: 10.1016/j.acuro.2016.04.014. PMID: 27890492

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