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Decreased urine bicarbonate concentration

MedGen UID:
868008
Concept ID:
C4022399
Finding
Synonym: Decreased urine HCO3 concentration
 
HPO: HP:0045011

Definition

Abnormally decreased concentration of hydrogencarbonate in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urine bicarbonate concentration

Professional guidelines

PubMed

Prot-Bertoye C, Lebbah S, Daudon M, Tostivint I, Jais JP, Lillo-Le Louët A, Pontoizeau C, Cochat P, Bataille P, Bridoux F, Brignon P, Choquenet C, Combe C, Conort P, Decramer S, Doré B, Dussol B, Essig M, Frimat M, Gaunez N, Joly D, Le Toquin-Bernard S, Méjean A, Meria P, Morin D, N'Guyen HV, Normand M, Pietak M, Ronco P, Saussine C, Tsimaratos M, Friedlander G, Traxer O, Knebelmann B, Courbebaisse M; French Cystinuria Group
BJU Int 2019 Nov;124(5):849-861. Epub 2019 Mar 25 doi: 10.1111/bju.14721. PMID: 30801923
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Moore KP, Holt SG, Patel RP, Svistunenko DA, Zackert W, Goodier D, Reeder BJ, Clozel M, Anand R, Cooper CE, Morrow JD, Wilson MT, Darley-Usmar V, Roberts LJ 2nd
J Biol Chem 1998 Nov 27;273(48):31731-7. doi: 10.1074/jbc.273.48.31731. PMID: 9822635

Recent clinical studies

Etiology

Hsu S, Bansal N, Denburg M, Ginsberg C, Hoofnagle AN, Isakova T, Ix JH, Robinson-Cohen C, Wolf M, Kestenbaum BR, de Boer IH, Zelnick LR
J Bone Miner Res 2024 May 2;39(4):433-442. doi: 10.1093/jbmr/zjae021. PMID: 38477777Free PMC Article
Tyson CC, Luciano A, Modliszewski JL, Corcoran DL, Bain JR, Muehlbauer M, Ilkayeva O, Pourafshar S, Allen J, Bowman C, Gung J, Asplin JR, Pendergast J, Svetkey LP, Lin PH, Scialla JJ
Am J Kidney Dis 2021 Jul;78(1):38-47. Epub 2021 Mar 31 doi: 10.1053/j.ajkd.2020.10.015. PMID: 33810868Free PMC Article
Liebman SE, Taylor JG, Bushinsky DA
Curr Rheumatol Rep 2007 Jun;9(3):251-7. doi: 10.1007/s11926-007-0040-z. PMID: 17531180
Worcester EM
Endocrinol Metab Clin North Am 2002 Dec;31(4):979-99. doi: 10.1016/s0889-8529(02)00035-x. PMID: 12474641
Manninen PH, Lam AM, Gelb AW, Brown SC
Can J Anaesth 1987 Sep;34(5):442-6. doi: 10.1007/BF03014345. PMID: 3117392

Diagnosis

Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M
Clin J Am Soc Nephrol 2020 Jan 7;15(1):16-24. Epub 2019 Dec 10 doi: 10.2215/CJN.07830719. PMID: 31822527Free PMC Article
Valavi E, Nickavar A, Aeene A
J Pediatr Urol 2019 Apr;15(2):165.e1-165.e4. Epub 2018 Nov 10 doi: 10.1016/j.jpurol.2018.11.003. PMID: 30528095
Gildea JJ, Xu P, Carlson JM, Gaglione RT, Bigler Wang D, Kemp BA, Reyes CM, McGrath HE, Carey RM, Jose PA, Felder RA
Am J Physiol Regul Integr Comp Physiol 2015 Dec 1;309(11):R1447-59. Epub 2015 Oct 7 doi: 10.1152/ajpregu.00150.2015. PMID: 26447209Free PMC Article
Verplaetse R, Tytgat J
Forensic Sci Int 2012 Feb 10;215(1-3):136-45. Epub 2011 Feb 26 doi: 10.1016/j.forsciint.2011.01.047. PMID: 21356580
Liebman SE, Taylor JG, Bushinsky DA
Curr Rheumatol Rep 2007 Jun;9(3):251-7. doi: 10.1007/s11926-007-0040-z. PMID: 17531180

Therapy

Tyson CC, Luciano A, Modliszewski JL, Corcoran DL, Bain JR, Muehlbauer M, Ilkayeva O, Pourafshar S, Allen J, Bowman C, Gung J, Asplin JR, Pendergast J, Svetkey LP, Lin PH, Scialla JJ
Am J Kidney Dis 2021 Jul;78(1):38-47. Epub 2021 Mar 31 doi: 10.1053/j.ajkd.2020.10.015. PMID: 33810868Free PMC Article
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970
Manninen PH, Lam AM, Gelb AW, Brown SC
Can J Anaesth 1987 Sep;34(5):442-6. doi: 10.1007/BF03014345. PMID: 3117392
Watson WA, Garrelts JC, Zinn PD, Garriott JC, McLemore TL, Clementi WA
J Toxicol Clin Toxicol 1984-1985;22(6):549-63. doi: 10.3109/15563658408992584. PMID: 6535847

Prognosis

Menezes CJ, Worcester EM, Coe FL, Asplin J, Bergsland KJ, Ko B
Am J Physiol Renal Physiol 2019 Jul 1;317(7):F65-F72. Epub 2019 Apr 24 doi: 10.1152/ajprenal.00066.2019. PMID: 31017011Free PMC Article
Yi JH, Shin HJ, Kim SM, Han SW, Kim HJ, Oh MS
Clin J Am Soc Nephrol 2012 Aug;7(8):1211-6. Epub 2012 Jun 14 doi: 10.2215/CJN.03230312. PMID: 22700881Free PMC Article
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Graber M, Corish D
Am J Kidney Dis 1991 Nov;18(5):527-45. doi: 10.1016/s0272-6386(12)80647-0. PMID: 1835285
Hernandez RE, Schambelan M, Cogan MG, Colman J, Morris RC Jr, Sebastian A
Kidney Int 1987 Jun;31(6):1356-67. doi: 10.1038/ki.1987.150. PMID: 3039234

Clinical prediction guides

Tsikas D
J Enzyme Inhib Med Chem 2024 Dec;39(1):2291336. Epub 2023 Dec 11 doi: 10.1080/14756366.2023.2291336. PMID: 38078375
Menezes CJ, Worcester EM, Coe FL, Asplin J, Bergsland KJ, Ko B
Am J Physiol Renal Physiol 2019 Jul 1;317(7):F65-F72. Epub 2019 Apr 24 doi: 10.1152/ajprenal.00066.2019. PMID: 31017011Free PMC Article
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Graber M, Corish D
Am J Kidney Dis 1991 Nov;18(5):527-45. doi: 10.1016/s0272-6386(12)80647-0. PMID: 1835285
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

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