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Ovarian microcystic stromal tumor

MedGen UID:
889995
Concept ID:
C4054287
Neoplastic Process
Synonyms: MCST; Microcystic stromal tumor; microcystic stromal tumor; microcystic stromal tumour; Ovarian Microcystic Stromal Tumor; ovarian microcystic stromal tumor
 
Monarch Initiative: MONDO:0006339
Orphanet: ORPHA569248

Definition

A rare benign ovarian stromal tumor characterized by a stromal neoplasm with variable microcystic morphology, low mitotic activity, and diffuse nuclear beta-catenin and cyclin D1 immunoreactivity, while inhibin and calretinin are not expressed. Patients most commonly present with symptoms of a unilateral pelvic mass. Hormonal manifestations are usually absent. The tumor may be associated with familial adenomatous polyposis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian microcystic stromal tumor

Professional guidelines

PubMed

Tchrakian N, Oliva E, Chong AS, Rivera-Polo B, Bennett JA, Nucci MR, Sah S, Schoolmeester JK, van der Griend RA, Foulkes WD, Clarke BA, Young RH, McCluggage WG
Am J Surg Pathol 2022 Dec 1;46(12):1599-1610. Epub 2022 Aug 29 doi: 10.1097/PAS.0000000000001954. PMID: 36040033
Rodriguez M, Kang EY, Farrington K, Cook LS, Le ND, Karnezis AN, Lee CH, Nelson GS, Terzic T, Lee S, Köbel M
Am J Surg Pathol 2021 Nov 1;45(11):1452-1463. doi: 10.1097/PAS.0000000000001798. PMID: 34534137
Burandt E, Young RH
Am J Surg Pathol 2014 Aug;38(8):1023-32. doi: 10.1097/PAS.0000000000000252. PMID: 25025365

Recent clinical studies

Etiology

Donthi D, Chen H, Peng Y, Niu S
Int J Gynecol Pathol 2023 Sep 1;42(5):491-495. Epub 2022 Aug 9 doi: 10.1097/PGP.0000000000000906. PMID: 36044304
Liu C, Gallagher RL, Price GR, Bolton E, Joy C, Harraway J, Venter DJ, Armes JE
Int J Gynecol Pathol 2016 Nov;35(6):561-565. doi: 10.1097/PGP.0000000000000289. PMID: 27015438

Diagnosis

Wu B, Wu C, Li D, Yang Z, Liu Y, Zhang HX, Xin HW, Bai Y
Intern Med 2024 Oct 15;63(20):2781-2785. Epub 2024 Mar 4 doi: 10.2169/internalmedicine.3221-23. PMID: 38432989Free PMC Article
He Y, Xu L, Feng M, Wang W
Medicine (Baltimore) 2020 Aug 21;99(34):e21841. doi: 10.1097/MD.0000000000021841. PMID: 32846831Free PMC Article
Zhang Y, Tao L, Yin C, Wang W, Zou H, Ren Y, Liang W, Jiang J, Zhang W, Jia W, Li F
Hum Pathol 2018 Aug;78:171-176. Epub 2018 Feb 17 doi: 10.1016/j.humpath.2018.02.012. PMID: 29458068
Liu C, Gallagher RL, Price GR, Bolton E, Joy C, Harraway J, Venter DJ, Armes JE
Int J Gynecol Pathol 2016 Nov;35(6):561-565. doi: 10.1097/PGP.0000000000000289. PMID: 27015438
Agaimy A, Haller F
Adv Anat Pathol 2016 Jan;23(1):1-12. doi: 10.1097/PAP.0000000000000104. PMID: 26645457

Prognosis

Donthi D, Chen H, Peng Y, Niu S
Int J Gynecol Pathol 2023 Sep 1;42(5):491-495. Epub 2022 Aug 9 doi: 10.1097/PGP.0000000000000906. PMID: 36044304
He Y, Xu L, Feng M, Wang W
Medicine (Baltimore) 2020 Aug 21;99(34):e21841. doi: 10.1097/MD.0000000000021841. PMID: 32846831Free PMC Article
Zhang Y, Tao L, Yin C, Wang W, Zou H, Ren Y, Liang W, Jiang J, Zhang W, Jia W, Li F
Hum Pathol 2018 Aug;78:171-176. Epub 2018 Feb 17 doi: 10.1016/j.humpath.2018.02.012. PMID: 29458068
Liu C, Gallagher RL, Price GR, Bolton E, Joy C, Harraway J, Venter DJ, Armes JE
Int J Gynecol Pathol 2016 Nov;35(6):561-565. doi: 10.1097/PGP.0000000000000289. PMID: 27015438

Clinical prediction guides

Liu C, Gallagher RL, Price GR, Bolton E, Joy C, Harraway J, Venter DJ, Armes JE
Int J Gynecol Pathol 2016 Nov;35(6):561-565. doi: 10.1097/PGP.0000000000000289. PMID: 27015438

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