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Ovarian benign neoplasm

MedGen UID:
14058
•Concept ID:
C0004997
•
Neoplastic Process
Synonyms: Benign neoplasm of ovary; Benign Neoplasm of Ovary; benign neoplasm of ovary; Benign Neoplasm of the Ovary; benign neoplasm of the ovary; Benign Ovarian Neoplasm; benign ovarian neoplasm; Benign ovarian tumor; Benign Ovarian Tumor; benign ovarian tumor; benign ovarian tumour; Benign Tumor of Ovary; benign tumor of ovary; Benign Tumor of the Ovary; benign tumor of the ovary; benign tumour of ovary; benign tumour of the ovary; ovarian benign neoplasm; ovary benign neoplasm
SNOMED CT: Benign ovarian tumor (92260003); Benign neoplasm of ovary (92260003)
 
Monarch Initiative: MONDO:0000646

Definition

A neoplasm that arises from the ovary and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include serous cystadenoma, mucinous cystadenoma, clear cell adenofibroma, benign Brenner tumor, thecoma, and fibroma. [from NCI]

Professional guidelines

PubMed

The prevalence of plasma heparin neutralizing activity and the effect of treatment on it in women with a gynecologic malignancy.
Wentworth P, Weiner C, Abas T, Turner D
Am J Obstet Gynecol 1988 Jul;159(1):194-9. doi: 10.1016/0002-9378(88)90520-0. PMID: 3260749

Recent clinical studies

Etiology

Ovarian-sparing surgery for ovarian tumors in children: A systematic review and meta-analysis.
Pio L, Abu-Zaid A, Zaghloul T, Halepota HF, Davidoff AM, Losty PD, Abdelhafeez HH
Eur J Surg Oncol 2023 Oct;49(10):106923. Epub 2023 May 18 doi: 10.1016/j.ejso.2023.04.022. PMID: 37211469
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Adnexal Masses in Adolescents.
Northridge JL
Pediatr Ann 2020 Apr 1;49(4):e183-e187. doi: 10.3928/19382359-20200227-01. PMID: 32275763
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article
Teratomas in childhood.
Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

Diagnosis

Malignant transformation of mature cystic teratoma of the ovary.
Atwi D, Kamal M, Quinton M, Hassell LA
J Obstet Gynaecol Res 2022 Dec;48(12):3068-3076. Epub 2022 Sep 2 doi: 10.1111/jog.15409. PMID: 36053141
Brenner tumors.
Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171Free PMC Article
Adnexal Masses in Adolescents.
Northridge JL
Pediatr Ann 2020 Apr 1;49(4):e183-e187. doi: 10.3928/19382359-20200227-01. PMID: 32275763
Ovarian neoplasms of childhood.
Lala SV, Strubel N
Pediatr Radiol 2019 Oct;49(11):1463-1475. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04456-8. PMID: 31620847
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article

Therapy

Racial and Ethnic Disparities in Clinical Trial Enrollment Among Women With Gynecologic Cancer.
Khadraoui W, Meade CE, Backes FJ, Felix AS
JAMA Netw Open 2023 Dec 1;6(12):e2346494. doi: 10.1001/jamanetworkopen.2023.46494. PMID: 38060227Free PMC Article
Immuno-Oncology for Gynecologic Malignancies.
How JA, Patel A, Jazaeri AA
Adv Exp Med Biol 2021;1342:193-232. doi: 10.1007/978-3-030-79308-1_6. PMID: 34972966
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.
Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, Wallace WH, Wang ET, Loren AW
J Clin Oncol 2018 Jul 1;36(19):1994-2001. Epub 2018 Apr 5 doi: 10.1200/JCO.2018.78.1914. PMID: 29620997
PARP inhibitors for anticancer therapy.
Curtin N
Biochem Soc Trans 2014 Feb;42(1):82-8. doi: 10.1042/BST20130187. PMID: 24450632
Survival analysis part I: basic concepts and first analyses.
Clark TG, Bradburn MJ, Love SB, Altman DG
Br J Cancer 2003 Jul 21;89(2):232-8. doi: 10.1038/sj.bjc.6601118. PMID: 12865907Free PMC Article

Prognosis

Ovarian cancer today and tomorrow: A global assessment by world region and Human Development Index using GLOBOCAN 2020.
Cabasag CJ, Fagan PJ, Ferlay J, Vignat J, Laversanne M, Liu L, van der Aa MA, Bray F, Soerjomataram I
Int J Cancer 2022 Nov 1;151(9):1535-1541. Epub 2022 Mar 30 doi: 10.1002/ijc.34002. PMID: 35322413
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Do patients have worse outcomes in heart failure than in cancer? A primary care-based cohort study with 10-year follow-up in Scotland.
Mamas MA, Sperrin M, Watson MC, Coutts A, Wilde K, Burton C, Kadam UT, Kwok CS, Clark AB, Murchie P, Buchan I, Hannaford PC, Myint PK
Eur J Heart Fail 2017 Sep;19(9):1095-1104. Epub 2017 May 3 doi: 10.1002/ejhf.822. PMID: 28470962
Bevacizumab-induced bowel perforation.
Sliesoraitis S, Tawfik B
J Am Osteopath Assoc 2011 Jul;111(7):437-41. PMID: 21803880
Extraovarian primary peritoneal carcinoma.
Eltabbakh GH, Piver MS
Oncology (Williston Park) 1998 Jun;12(6):813-9; discussion 820, 825-6. PMID: 9644683

Clinical prediction guides

Reducing Unnecessary Oophorectomies for Benign Ovarian Neoplasms in Pediatric Patients.
Minneci PC, Bergus KC, Lutz C, Aldrink J, Bence C, Breech L, Dillon PA, Downard C, Ehrlich PF, Fallat M, Fraser JD, Grabowski J, Helmrath M, Hertweck P, Hewitt G, Hirschl RB, Kabre R, Lal DR, Landman M, Leys C, Mak G, Markel T, Pressey J, Raiji M, Rymeski B, Saito J, Sato TT, St Peter SD, Cooper J, Deans K; Midwest Pediatric Surgery Consortium
JAMA 2023 Oct 3;330(13):1247-1254. doi: 10.1001/jama.2023.17183. PMID: 37787794Free PMC Article
Prediction of therapy response in ovarian cancer: Where are we now?
El Bairi K, Amrani M, Kandhro AH, Afqir S
Crit Rev Clin Lab Sci 2017 Jun;54(4):233-266. Epub 2017 Apr 26 doi: 10.1080/10408363.2017.1313190. PMID: 28443762
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480
Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic study.
Van Calster B, Van Hoorde K, Valentin L, Testa AC, Fischerova D, Van Holsbeke C, Savelli L, Franchi D, Epstein E, Kaijser J, Van Belle V, Czekierdowski A, Guerriero S, Fruscio R, Lanzani C, Scala F, Bourne T, Timmerman D; International Ovarian Tumour Analysis Group
BMJ 2014 Oct 15;349:g5920. doi: 10.1136/bmj.g5920. PMID: 25320247Free PMC Article
Ovarian incidentaloma.
Solnik MJ, Alexander C
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):105-16. doi: 10.1016/j.beem.2011.07.002. PMID: 22305456

Recent systematic reviews

Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.
Lee YC, Lee YL, Li CY
Medicina (Kaunas) 2021 Aug 30;57(9) doi: 10.3390/medicina57090905. PMID: 34577828Free PMC Article
Use of oral contraceptives in BRCA mutation carriers and risk for ovarian and breast cancer: a systematic review.
Huber D, Seitz S, Kast K, Emons G, Ortmann O
Arch Gynecol Obstet 2020 Apr;301(4):875-884. Epub 2020 Mar 5 doi: 10.1007/s00404-020-05458-w. PMID: 32140806Free PMC Article
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.
Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, Wallace WH, Wang ET, Loren AW
J Clin Oncol 2018 Jul 1;36(19):1994-2001. Epub 2018 Apr 5 doi: 10.1200/JCO.2018.78.1914. PMID: 29620997
Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Barry JA, Azizia MM, Hardiman PJ
Hum Reprod Update 2014 Sep-Oct;20(5):748-58. Epub 2014 Mar 30 doi: 10.1093/humupd/dmu012. PMID: 24688118Free PMC Article

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