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Osseous metaplasia

MedGen UID:
90738
•Concept ID:
C0334040
•
Pathologic Function
Synonyms: Bone Metaplasia; Extraskeletal ossification; Metaplastic ossification; Osseous Metaplasia; Osteosis
SNOMED CT: Osseous metaplasia (38109001); Metaplastic ossification (38109001); Extraskeletal ossification (38109001); Osteosis (38109001)

Definition

Heterotopic formation of normal bone within soft tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsseous metaplasia

Professional guidelines

PubMed

Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis.
Yao H, Wang B, Wen L, Jin Q, Li H, Huang G, Yin J, Zou C, Xie X, Shen J
BMC Cancer 2018 Nov 29;18(1):1195. doi: 10.1186/s12885-018-5062-6. PMID: 30497436Free PMC Article
Anti-angiogenic therapy, a new player in the field of sarcoma treatment.
Versleijen-Jonkers YM, Vlenterie M, van de Luijtgaarden AC, van der Graaf WT
Crit Rev Oncol Hematol 2014 Aug;91(2):172-85. Epub 2014 Feb 15 doi: 10.1016/j.critrevonc.2014.02.001. PMID: 24613529
Interventional management of hypervascular osseous metastasis: role of embolotherapy before orthopedic tumor resection and bone stabilization.
Kickuth R, Waldherr C, Hoppe H, Bonel HM, Ludwig K, Beck M, Triller J
AJR Am J Roentgenol 2008 Dec;191(6):W240-7. doi: 10.2214/AJR.07.4037. PMID: 19020210

Recent clinical studies

Etiology

GLI1 Coamplification in Well-Differentiated/Dedifferentiated Liposarcomas: Clinicopathologic and Molecular Analysis of 92 Cases.
Sharma AE, Dickson M, Singer S, Hameed MR, Agaram NP
Mod Pathol 2024 Jun;37(6):100494. Epub 2024 Apr 15 doi: 10.1016/j.modpat.2024.100494. PMID: 38621503Free PMC Article
Endometrial and cervical osseous metaplasia with extramedullary haematopoiesis presenting as amenorrhea: Report of three cases.
Jamal I, Gupta RK, Raj S, Bhadani PP
Indian J Pathol Microbiol 2020 Apr-Jun;63(2):295-297. doi: 10.4103/IJPM.IJPM_574_18. PMID: 32317538
Areas of Cartilaginous and Osseous Metaplasia After Experimental Myocardial Infarction in Rats.
Manole CG, Marinescu BG, Marta D, Nicolescu MI
Anat Rec (Hoboken) 2019 Jun;302(6):947-953. Epub 2018 Nov 28 doi: 10.1002/ar.24010. PMID: 30369066
Case 237: Renal Cell Carcinoma with Osseous Metaplasia.
Lai BM, Ka SY, Kan WK, Lam MW, Lee TF, Lui YH, Khoo JL
Radiology 2017 Jan;282(1):293-298. doi: 10.1148/radiol.2016140817. PMID: 28005510
Review and update: oncogenic osteomalacia-rickets.
Weidner N
Ultrastruct Pathol 1991 Jul-Oct;15(4-5):317-33. doi: 10.3109/01913129109016242. PMID: 1755097

Diagnosis

Osseous Metaplasia of the Eyelid in a Child.
Charles NC, DeMaria LN, Viriya ET
Ophthalmic Plast Reconstr Surg 2021 Sep-Oct 01;37(5):e187-e188. doi: 10.1097/IOP.0000000000001999. PMID: 34284424
Intraocular ossification. Case report.
Maftei C, Stanca HT
Rom J Ophthalmol 2017 Jan-Mar;61(1):65-68. doi: 10.22336/rjo.2017.12. PMID: 29450374Free PMC Article
Vaginal osseous metaplasia.
Landim FM, Tavares JM, de Melo Braga DN, da Silva JE Jr, Bastos Filho JB, Feitosa RG
Arch Gynecol Obstet 2009 Mar;279(3):381-4. Epub 2008 Jun 18 doi: 10.1007/s00404-008-0706-4. PMID: 18563423
Endometrial ossification.
Ejeckam GC, Haseeb F, Ahamad R, Azadeh B
Trop Geogr Med 1991 Jul;43(3):314-6. PMID: 1816670
Cranial fasciitis of childhood.
Lauer DH, Enzinger FM
Cancer 1980 Jan 15;45(2):401-6. doi: 10.1002/1097-0142(19800115)45:2<401::aid-cncr2820450236>3.0.co;2-c. PMID: 7351023

Therapy

The Beneficial Effects of Erbium:Yttrium-Aluminum-Garnet Laser in an Ulcer Caused by Lower Leg Arteriopathy.
Botsali A, Caliskan E, Tunca M
J Am Podiatr Med Assoc 2021 Dec 15;111(6) doi: 10.7547/20-099. PMID: 35061599
Adenocarcinoma With Osseous Metaplasia: Is It Bad to the Bone?
Mastracci L, Ficarra G, Bianchi R, Pesce F, Grillo F
Int J Surg Pathol 2020 Feb;28(1):70-72. Epub 2019 Apr 8 doi: 10.1177/1066896919842204. PMID: 30955387
A Case of Secondary Osteoma Cutis Associated with Lichen Planopilaris.
Orlando G, Salmaso R, Piaserico S
Acta Derm Venereol 2019 Nov 1;99(12):1190-1191. doi: 10.2340/00015555-3295. PMID: 31449318
Giant ossifying malignant thymoma in a child.
Bikhchandani J, Valusek PA, Juang D, E O'Brien J Jr, Hetherington M, St Peter SD
J Pediatr Surg 2010 Sep;45(9):e31-4. doi: 10.1016/j.jpedsurg.2010.06.021. PMID: 20850614
Endometrial ossification.
Ejeckam GC, Haseeb F, Ahamad R, Azadeh B
Trop Geogr Med 1991 Jul;43(3):314-6. PMID: 1816670

Prognosis

Heterotopic bone formation in a case of clear cell renal cell carcinoma: A case report.
Bavikar R, Patel P, Verma A, Ingale Y, Randive R
J Cancer Res Ther 2024 Jan 1;20(1):482-484. Epub 2023 Apr 5 doi: 10.4103/jcrt.jcrt_2085_22. PMID: 38554371
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Heterotopic Bone Formation in Clear Cell Renal Cell Carcinoma.
Mitra AP, Chopra S, Ghodoussipour S, Schuckman AK
Urology 2020 Oct;144:13-14. Epub 2020 Jul 25 doi: 10.1016/j.urology.2020.07.026. PMID: 32721514
Adenocarcinoma With Osseous Metaplasia: Is It Bad to the Bone?
Mastracci L, Ficarra G, Bianchi R, Pesce F, Grillo F
Int J Surg Pathol 2020 Feb;28(1):70-72. Epub 2019 Apr 8 doi: 10.1177/1066896919842204. PMID: 30955387
Cranial fasciitis of childhood.
Lauer DH, Enzinger FM
Cancer 1980 Jan 15;45(2):401-6. doi: 10.1002/1097-0142(19800115)45:2<401::aid-cncr2820450236>3.0.co;2-c. PMID: 7351023

Clinical prediction guides

GLI1 Coamplification in Well-Differentiated/Dedifferentiated Liposarcomas: Clinicopathologic and Molecular Analysis of 92 Cases.
Sharma AE, Dickson M, Singer S, Hameed MR, Agaram NP
Mod Pathol 2024 Jun;37(6):100494. Epub 2024 Apr 15 doi: 10.1016/j.modpat.2024.100494. PMID: 38621503Free PMC Article
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Osseous and chondromatous metaplasia in calcific aortic valve stenosis.
Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA
Cardiovasc Pathol 2016 Jan-Feb;25(1):18-24. Epub 2015 Aug 29 doi: 10.1016/j.carpath.2015.08.008. PMID: 26386747
Ossifying trichilemmal cyst.
Pusiol T, Morichetti D, Zorzi MG, Piscioli F
Am J Dermatopathol 2011 Dec;33(8):867-8. doi: 10.1097/DAD.0b013e31821b0abd. PMID: 22042263
Ossifying adult xanthogranuloma.
Salamanca J, Rodriguez-Peralto JL, Gonzalez-Lois C, Azorin D
Arch Pathol Lab Med 2003 Oct;127(10):e409-10. doi: 10.5858/2003-127-e409-OAX. PMID: 14521441

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