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Islet Cell Adenoma

MedGen UID:
9562
•Concept ID:
C0022134
•
Neoplastic Process
Synonyms: Adenoma, Islet Cell; Adenomas, Islet Cell; Islet Cell Adenomas
SNOMED CT: Islet cell adenoma (76345009); Islet cell tumor, benign (76345009); Pancreatic endocrine tumor, benign (76345009)

Definition

A benign endocrine neoplasm arising from the pancreas. It is separated from the normal pancreatic tissues by a thin collagenous capsule. It may secrete a hormone (e.g. insulin, gastrin) or it may be non-functional. [from NCI]

Professional guidelines

PubMed

Surgical treatment of organic pancreatic hypoglycemia in the pediatric age.
Carcassonne M, DeLarue A, LeTourneau JN
J Pediatr Surg 1983 Feb;18(1):75-9. doi: 10.1016/s0022-3468(83)80277-2. PMID: 6300364
Surgical management of islet-cell adenoma in infancy.
Rich RH, Dehner LP, Okinaga K, Deeb LC, Ulstrom RA, Leonard AS
Surgery 1978 Oct;84(4):519-26. PMID: 211657
Medical treatment of endogenous organic hyperinsulinism.
Scandellari C, Zaccaria M, Sicolo N, Casara D, Erle G, Federspil G
Horm Metab Res 1976;Suppl 6:46-54. PMID: 179929

Recent clinical studies

Etiology

Pancreatic neuroendocrine tumours.
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Central pancreatectomy revisited.
Roggin KK, Rudloff U, Blumgart LH, Brennan MF
J Gastrointest Surg 2006 Jun;10(6):804-12. doi: 10.1016/j.gassur.2005.11.012. PMID: 16769536
Calcitonin-secreting VIPoma.
Jackson C, Buchman AL
Dig Dis Sci 2005 Dec;50(12):2203-6. doi: 10.1007/s10620-005-3034-6. PMID: 16416161
Islet cell tumors of the pancreas.
Bieligk S, Jaffe BM
Surg Clin North Am 1995 Oct;75(5):1025-40. doi: 10.1016/s0039-6109(16)46744-7. PMID: 7660247
Total pancreatectomy.
ReMine WH, Priestley JT, Judd ES, King JN
Ann Surg 1970 Oct;172(4):595-604. doi: 10.1097/00000658-197010000-00006. PMID: 4318798Free PMC Article

Diagnosis

Pancreatic neuroendocrine tumours.
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
The glucagonoma syndrome.
Lewis AE
Int J Dermatol 1979 Jan-Feb;18(1):17-22. doi: 10.1111/j.1365-4362.1979.tb01904.x. PMID: 216645
The glucagonoma syndrome.
Bloom SR, Polak JM
Adv Exp Med Biol 1978;106:183-94. doi: 10.1007/978-1-4684-7248-6_23. PMID: 213958
Insulinomas.
Nardi GL
Adv Surg 1971;5:103-8. PMID: 4330848
LEUCINE-INDUCED HYPOGLYCEMIA.
FAJANS SS
N Engl J Med 1965 Jun 10;272:1224-7. doi: 10.1056/NEJM196506102722308. PMID: 14284995

Therapy

Hypoglycaemia.
Gale E
Clin Endocrinol Metab 1980 Nov;9(3):461-75. PMID: 6260399
The glucagonoma syndrome.
Bloom SR, Polak JM
Adv Exp Med Biol 1978;106:183-94. doi: 10.1007/978-1-4684-7248-6_23. PMID: 213958
Glucagon.
Br Med J 1971 Aug 26;3(5773):524-5. PMID: 4327680Free PMC Article
Total pancreatectomy.
ReMine WH, Priestley JT, Judd ES, King JN
Ann Surg 1970 Oct;172(4):595-604. doi: 10.1097/00000658-197010000-00006. PMID: 4318798Free PMC Article
Glucagon.
Foà PP
Ergeb Physiol 1968;60:141-219. doi: 10.1007/BFb0107253. PMID: 4298671

Prognosis

Pancreatic neuroendocrine tumours.
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523
Calcitonin-secreting VIPoma.
Jackson C, Buchman AL
Dig Dis Sci 2005 Dec;50(12):2203-6. doi: 10.1007/s10620-005-3034-6. PMID: 16416161
Glucagonoma tumors and syndrome.
Montenegro-Rodas F, Samaan NA
Curr Probl Cancer 1981 Dec;6(6):1-54. doi: 10.1016/s0147-0272(81)80014-1. PMID: 6276079
The glucagonoma syndrome.
Lewis AE
Int J Dermatol 1979 Jan-Feb;18(1):17-22. doi: 10.1111/j.1365-4362.1979.tb01904.x. PMID: 216645
Total pancreatectomy.
ReMine WH, Priestley JT, Judd ES, King JN
Ann Surg 1970 Oct;172(4):595-604. doi: 10.1097/00000658-197010000-00006. PMID: 4318798Free PMC Article

Clinical prediction guides

Islet Tumors: Resect or Follow?
Sinclair TJ, Poultsides GA
Adv Surg 2020 Sep;54:69-88. Epub 2020 Jun 17 doi: 10.1016/j.yasu.2020.04.004. PMID: 32713440
Anatomic distribution of pancreatic endocrine tumors.
Howard TJ, Stabile BE, Zinner MJ, Chang S, Bhagavan BS, Passaro E Jr
Am J Surg 1990 Feb;159(2):258-64. doi: 10.1016/s0002-9610(05)80276-4. PMID: 2154144
VIPoma syndrome.
Krejs GJ
Am J Med 1987 May 29;82(5B):37-48. doi: 10.1016/0002-9343(87)90425-6. PMID: 3035922
The glucagonoma syndrome.
Lewis AE
Int J Dermatol 1979 Jan-Feb;18(1):17-22. doi: 10.1111/j.1365-4362.1979.tb01904.x. PMID: 216645
The APUD cell system and its neoplasms: observations on the significance and limitations of the concept.
Gould VE, Memoli V, Chejfec G, Johannessen JV
Surg Clin North Am 1979 Feb;59(1):93-108. doi: 10.1016/s0039-6109(16)41736-6. PMID: 35846

Recent systematic reviews

Postoperative Complications, In-Hospital Mortality and 5-Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review.
Jilesen AP, van Eijck CH, in't Hof KH, van Dieren S, Gouma DJ, van Dijkum EJ
World J Surg 2016 Mar;40(3):729-48. doi: 10.1007/s00268-015-3328-6. PMID: 26661846Free PMC Article

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