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Legionnaires disease

MedGen UID:: 9705
•Concept ID:: C0023241
•: Disease or Syndrome

Synonyms:	Legionnaire's disease; Legionnaires' disease
SNOMED CT:	Legionella pneumonia (195889001); Legionnaire's disease (195889001); Legionnaires' disease (195889001); Legionnaires disease (195889001); Infection caused by Legionella pneumophilia (269574000); Infection by Legionella pneumophilia (269574000)

Related gene: Gene(s) associated with related conditions. For conditions in a hierarchy, the parent condition will list the genes associated with the children conditions.	TLR5

Monarch Initiative:	MONDO:0005824

Definition

A pneumonia caused by Legionella pneumophila and other Legionella species, which is characterized by fever, cough, progressive respiratory distress, and which is often accompanied by extrapulmonary manifestations. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLegionella infection
- CROGVLegionnaires disease
  - CROGVLegionnaire disease, susceptibility to
- CROGVPontiac fever

Clinical finding
- Finding by Cause
  - Infection
    - Bacterial Infections and Mycoses
      - Bacterial infectious disease
        Bacterial pneumonia
        Legionnaires disease
        Legionnaire disease, susceptibility to

Professional guidelines

PubMed

Antimicrobial therapy and patient management for severe Legionnaires' pneumonia.

Rello J, Sabater-Riera J
Eur J Intern Med 2024 Oct;128:136-137. Epub 2024 Aug 13 doi: 10.1016/j.ejim.2024.08.002. PMID: 39142936

The treatment of Legionnaires' disease.

Dedicoat M, Venkatesan P
J Antimicrob Chemother 1999 Jun;43(6):747-52. doi: 10.1093/jac/43.6.747. PMID: 10404312

Legionnaires' disease: diagnosis and management.

Ann Intern Med 1978 Mar;88(3):363-5. doi: 10.7326/0003-4819-88-3-363. PMID: 343681

See all (57)

Recent clinical studies

Etiology

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Legionnaires' disease.

Gould D
Nurs Stand 2003 Jul 23-29;17(45):41-4. doi: 10.7748/ns.17.45.41.s55. PMID: 12929345

Legionella and immunosuppression.

Schlossberg D, Bonoan J
Semin Respir Infect 1998 Jun;13(2):128-31. PMID: 9643390

Legionellosis.

Stout JE, Yu VL
N Engl J Med 1997 Sep 4;337(10):682-7. doi: 10.1056/NEJM199709043371006. PMID: 9278466

Legionellosis.

Blackmon JA, Chandler FW, Cherry WB, England AC 3rd, Feeley JC, Hicklin MD, McKinney RM, Wilkinson HW
Am J Pathol 1981 Jun;103(3):429-65. PMID: 7015873 Free PMC Article

See all (1019)

Diagnosis

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Legionella and Legionnaires' disease: 25 years of investigation.

Fields BS, Benson RF, Besser RE
Clin Microbiol Rev 2002 Jul;15(3):506-26. doi: 10.1128/CMR.15.3.506-526.2002. PMID: 12097254 Free PMC Article

Legionellosis.

Stout JE, Yu VL
N Engl J Med 1997 Sep 4;337(10):682-7. doi: 10.1056/NEJM199709043371006. PMID: 9278466

Legionnaires' disease.

Strausbaugh LJ
Int J Dermatol 1983 May;22(4):239-44. doi: 10.1111/j.1365-4362.1983.tb03376.x. PMID: 6345418

Legionellosis.

Blackmon JA, Chandler FW, Cherry WB, England AC 3rd, Feeley JC, Hicklin MD, McKinney RM, Wilkinson HW
Am J Pathol 1981 Jun;103(3):429-65. PMID: 7015873 Free PMC Article

See all (1563)

Therapy

Severe Pneumonia Caused by Legionella pneumophila: Differential Diagnosis and Therapeutic Considerations.

Chahin A, Opal SM
Infect Dis Clin North Am 2017 Mar;31(1):111-121. doi: 10.1016/j.idc.2016.10.009. PMID: 28159171 Free PMC Article

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Legionellosis.

Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

Legionnaires' disease.

Shands KN, Fraser DW
Dis Mon 1980 Dec;27(3):1-59. doi: 10.1016/s0011-5029(80)80010-1. PMID: 7006946

Legionnaires' disease.

Meyer RD, Finegold SM
Annu Rev Med 1980;31:219-32. doi: 10.1146/annurev.me.31.020180.001251. PMID: 6994607

See all (697)

Prognosis

Legionnaires' disease.

Cunha BA, Burillo A, Bouza E
Lancet 2016 Jan 23;387(10016):376-385. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)60078-2. PMID: 26231463

Community-acquired pneumonia among smokers.

Almirall J, Blanquer J, Bello S
Arch Bronconeumol 2014 Jun;50(6):250-4. Epub 2013 Dec 31 doi: 10.1016/j.arbres.2013.11.016. PMID: 24387877

Treatment of Legionnaires' disease.

Amsden GW
Drugs 2005;65(5):605-14. doi: 10.2165/00003495-200565050-00003. PMID: 15748096

Legionnaires' disease: a rational approach to therapy.

Roig J, Rello J
J Antimicrob Chemother 2003 May;51(5):1119-29. Epub 2003 Mar 28 doi: 10.1093/jac/dkg191. PMID: 12668578

Legionnaires' disease.

Roig J, Domingo C, Morera J
Chest 1994 Jun;105(6):1817-25. doi: 10.1378/chest.105.6.1817. PMID: 8205883

See all (505)

Clinical prediction guides

Sde proteins coordinate ubiquitin utilization and phosphoribosylation to establish and maintain the Legionella replication vacuole.

Kotewicz KM, Zhang M, Kim S, Martin MS, Roy Chowdhury A, Tai A, Scheck RA, Isberg RR
Nat Commun 2024 Aug 30;15(1):7479. doi: 10.1038/s41467-024-51272-2. PMID: 39214970 Free PMC Article

Legionella prediction score.

Miyashita N
Respir Investig 2024 Mar;62(2):305-306. Epub 2024 Jan 31 doi: 10.1016/j.resinv.2024.01.008. PMID: 38301531

Community-acquired pneumonia among smokers.

Almirall J, Blanquer J, Bello S
Arch Bronconeumol 2014 Jun;50(6):250-4. Epub 2013 Dec 31 doi: 10.1016/j.arbres.2013.11.016. PMID: 24387877

The atypical pneumonias: clinical diagnosis and importance.

Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925 Free PMC Article

Legionellosis.

Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

See all (459)

Recent systematic reviews

Legionella pneumonia in hospitalized adults with respiratory failure: Quinolones or macrolides?

Ruiz-Spinelli A, Rello J
Eur J Intern Med 2024 Feb;120:62-68. Epub 2023 Sep 18 doi: 10.1016/j.ejim.2023.09.013. PMID: 37730517

A meta-analysis of Legionella pneumophila contamination in hospital water systems.

Fang Z, Zhou X, Liao H, Xu H
Am J Infect Control 2023 Nov;51(11):1250-1262. Epub 2023 Apr 11 doi: 10.1016/j.ajic.2023.04.002. PMID: 37054892

Meteorological conditions and Legionnaires' disease sporadic cases-a systematic review.

Pampaka D, Gómez-Barroso D, López-Perea N, Carmona R, Portero RC
Environ Res 2022 Nov;214(Pt 4):114080. Epub 2022 Aug 11 doi: 10.1016/j.envres.2022.114080. PMID: 35964674

Accuracy of diagnostic tests for Legionnaires' disease: a systematic review.

Cristovam E, Almeida D, Caldeira D, Ferreira JJ, Marques T
J Med Microbiol 2017 Apr;66(4):485-489. doi: 10.1099/jmm.0.000454. PMID: 28463665

An update on Legionella.

Carratalà J, Garcia-Vidal C
Curr Opin Infect Dis 2010 Apr;23(2):152-7. doi: 10.1097/QCO.0b013e328336835b. PMID: 20051846

See all (15)

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Links from PMC

Legionnaires disease

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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Practice guidelines

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