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    par-5 14-3-3 domain-containing protein;14-3-3-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 178113, updated on 9-Dec-2024

    Summary

    Official Symbol
    par-5
    Official Full Name
    14-3-3 domain-containing protein;14-3-3-like protein 1
    Primary source
    WormBase:WBGene00003920
    Locus tag
    CELE_M117.2
    See related
    AllianceGenome:WB:WBGene00003920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including asymmetric protein localization involved in cell fate determination; determination of adult lifespan; and first cell cycle pseudocleavage. Located in cell cortex and nucleus. Is expressed in germ cell; gonad; and head neurons. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to several human genes including YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See par-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (11820506..11821917, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 14-3-3 domain-containing protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in asymmetric protein localization involved in cell fate determination PubMed 
    involved_in cell fate specification PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in establishment of mitotic spindle orientation PubMed 
    involved_in first cell cycle pseudocleavage PubMed 
    involved_in heat acclimation PubMed 
    involved_in heat acclimation PubMed 
    involved_in meiotic cell cycle PubMed 
    involved_in polarity specification of anterior/posterior axis PubMed 
    involved_in pronuclear migration PubMed 
    involved_in protein export from nucleus PubMed 
    involved_in protein localization  
    involved_in regulation of mitotic cell cycle PubMed 
    involved_in reproductive process PubMed 
    involved_in signal transduction  
    involved_in zygote asymmetric cell division PubMed 
    Component Evidence Code Pubs
    located_in cell cortex PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    14-3-3 domain-containing protein;14-3-3-like protein 1
    NP_001368180.1
    • Confirmed by transcript evidence
    NP_001369936.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11820506..11821917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383210.2NP_001369936.1  14-3-3-like protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41932, Q21537
      Conserved Domains (1) summary
      cl02098
      Location:6232
      14-3-3; 14-3-3 domain
    2. NM_001380472.1NP_001368180.1  14-3-3 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NV25
      Conserved Domains (1) summary
      cl02098
      Location:1110
      14-3-3; 14-3-3 domain
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