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    DUS4 tRNA dihydrouridine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851121, updated on 4-Jan-2025

    Summary

    Official Symbol
    DUS4
    Official Full Name
    tRNA dihydrouridine synthase
    Primary source
    SGD:S000004397
    Locus tag
    YLR405W
    See related
    AllianceGenome:SGD:S000004397; FungiDB:YLR405W; VEuPathDB:YLR405W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See DUS4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (929789..930892)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene zinc-coordinating transcription factor SFP1 Neighboring gene seipin Neighboring gene ribosomal 60S subunit protein L31B Neighboring gene uncharacterized protein

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding  
    enables mRNA dihydrouridine synthase activity  
    enables oxidoreductase activity  
    enables tRNA dihydrouridine synthase activity  
    enables tRNA dihydrouridine synthase activity  
    enables tRNA dihydrouridine synthase activity PubMed 
    enables tRNA-dihydrouridine20a synthase activity  
    enables tRNA-dihydrouridine20b synthase activity  
    Process Evidence Code Pubs
    involved_in mRNA processing  
    involved_in tRNA dihydrouridine synthesis  
    involved_in tRNA modification PubMed 
    involved_in tRNA processing  
    Component Evidence Code Pubs
    is_active_in cellular_component  

    General protein information

    Preferred Names
    tRNA dihydrouridine synthase
    NP_013509.1
    • Dihydrouridine synthase; modifies pre-tRNAs at U20a and U20b of the D loop; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      929789..930892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182293.1NP_013509.1  TPA: tRNA dihydrouridine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013509.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ38, Q06063
      UniProtKB/TrEMBL
      B3RHR7, C8ZE14, N1P7C8
      Conserved Domains (1) summary
      pfam01207
      Location:45361
      Dus; Dihydrouridine synthase (Dus)
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