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PEP7 phosphatidylinositol-3-phosphate binding protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 851923, updated on 4-Jan-2025

Summary

Official Symbol
PEP7
Official Full Name
phosphatidylinositol-3-phosphate binding protein
Primary source
SGD:S000002731
Locus tag
YDR323C
See related
AllianceGenome:SGD:S000002731; FungiDB:YDR323C; VEuPathDB:YDR323C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
VAC1; VPL21; VPS19; VPT19
Summary
Enables phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including post-Golgi vesicle-mediated transport; vacuole inheritance; and vesicle docking involved in exocytosis. Located in cytoplasmic side of endosome membrane. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See PEP7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1112480..1114027, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL35 Neighboring gene F1F0 ATP synthase subunit e Neighboring gene Utp4p Neighboring gene condensin subunit YCG1

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding  
enables phosphatidylinositol-3-phosphate binding PubMed 
enables phosphatidylinositol-3-phosphate binding  
enables zinc ion binding PubMed 
Component Evidence Code Pubs
located_in bounding membrane of organelle  
located_in cytoplasm PubMed 
located_in cytoplasm PubMed 
located_in cytoplasmic side of endosome membrane PubMed 
located_in cytosol  
located_in membrane  
located_in nucleus PubMed 
located_in vacuolar membrane  
located_in vacuole  

General protein information

Preferred Names
phosphatidylinositol-3-phosphate binding protein
NP_010610.3
  • Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1112480..1114027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180631.3NP_010610.3  TPA: phosphatidylinositol-3-phosphate binding protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010610.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSV6, P32609, Q99229
    UniProtKB/TrEMBL
    A6ZYS6, G2WB63, N1P6X4
    Conserved Domains (3) summary
    cd15737
    Location:211293
    FYVE2_Vac1p_like; FYVE domain 2 found in yeast protein VAC1 (Vac1p) and similar proteins
    cd15761
    Location:65141
    FYVE1_Vac1p_like; FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins
    pfam11464
    Location:467502
    Rbsn; Rabenosyn Rab binding domain
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