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MOB1 Mob1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854700, updated on 4-Jan-2025

Summary

Official Symbol
MOB1
Official Full Name
Mob1p
Primary source
SGD:S000001368
Locus tag
YIL106W
See related
AllianceGenome:SGD:S000001368; FungiDB:YIL106W; VEuPathDB:YIL106W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables kinase regulator activity. Involved in mitotic cytokinesis and regulation of exit from mitosis. Located in cellular bud neck and mitotic spindle pole body. Part of Sid2-Mob1 complex. Orthologous to several human genes including MOB1A (MOB kinase activator 1A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See MOB1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
2
Sequence:
Chromosome: IX; NC_001141.2 (166415..167444)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative metalloendopeptidase Neighboring gene 6-phosphofructo-2-kinase Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositol 4,5-bisphosphate-binding protein Neighboring gene Hsp90 cochaperone SHQ1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables kinase regulator activity PubMed 
enables metal ion binding  
enables protein kinase activator activity  
enables zinc ion binding PubMed 
Process Evidence Code Pubs
involved_in cell division  
involved_in cell division  
involved_in mitotic cytokinesis PubMed 
involved_in regulation of exit from mitosis PubMed 
involved_in regulation of exit from mitosis PubMed 
involved_in signal transduction  
Component Evidence Code Pubs
part_of Sid2-Mob1 complex PubMed 
part_of Sid2-Mob1 complex PubMed 
located_in cellular bud neck PubMed 
located_in cellular bud neck  
located_in chromosome  
located_in chromosome, centromeric region  
located_in cytoplasm PubMed 
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoskeleton  
located_in mitotic spindle pole body PubMed 
located_in nuclear periphery PubMed 
is_active_in nucleus  
located_in nucleus  
located_in spindle pole body PubMed 
located_in spindle pole body  

General protein information

Preferred Names
Mob1p
NP_012160.2
  • Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    166415..167444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179454.1NP_012160.2  TPA: Mob1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012160.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVI1, P40484
    UniProtKB/TrEMBL
    A6ZVH1, B3LTV3, C8ZAD9, G2WG46, N1P0W7
    Conserved Domains (1) summary
    pfam03637
    Location:134304
    Mob1_phocein; Mob1/phocein family
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