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    Cep131 centrosomal protein 131 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep131provided by RGD
    Official Full Name
    centrosomal protein 131provided by RGD
    Primary source
    RGD:1307745
    See related
    EnsemblRapid:ENSRNOG00000004430 AllianceGenome:RGD:1307745
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Azi1
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including intraciliary transport involved in cilium assembly; protein localization to centrosome; and regulation of centrosome duplication. Predicted to act upstream of or within cilium organization and spermatid development. Predicted to be located in several cellular components, including microtubule organizing center; nucleus; and sperm head-tail coupling apparatus. Predicted to be active in centriolar satellite. Orthologous to human CEP131 (centrosomal protein 131). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 88.9), Heart (RPKM 65.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep131 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105844433..105868811, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105346015..105370380, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109243240..109267636, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555825 Neighboring gene BAR/IMD domain containing adaptor protein 2 Neighboring gene apoptosis-associated tyrosine kinase Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene microRNA 3594 Neighboring gene microRNA 3562 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids. Aoto H, et al. Eur J Biochem, 1995 Nov 15. PMID 8529672
    2. The centriolar satellite protein Cep131 is important for genome stability. Staples CJ, et al. J Cell Sci, 2012 Oct 15. PMID 22797915
    3. Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. Hall EA, et al. PLoS Genet, 2013. PMID 24415959, Free PMC Article
    4. SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. Airik R, et al. PLoS One, 2016. PMID 27224062, Free PMC Article
    5. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Kodani A, et al. Elife, 2015 Aug 22. PMID 26297806, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intraciliary transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intramanchette transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within manchette assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in manchette IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 131 kDa
    Names
    5-azacytidine induced 1
    5-azacytidine induced gene 1
    5-azacytidine-induced protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108310.1 → NP_001101780.1  centrosomal protein of 131 kDa

      See identical proteins and their annotated locations for NP_001101780.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HLA8, D4AEL8
      Conserved Domains (1) summary
      PHA03252
      Location:887 → 948
      PHA03252; DNA packaging tegument protein UL25; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      105844433..105868811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086440.2 → XP_038942368.1  centrosomal protein of 131 kDa isoform X1

      UniProtKB/TrEMBL
      D4AEL8
      Related
      ENSRNOP00000005977.7, ENSRNOT00000005977.8
      Conserved Domains (2) summary
      PTZ00121
      Location:274 → 940
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:718 → 1024
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039086441.2 → XP_038942369.1  centrosomal protein of 131 kDa isoform X2

      UniProtKB/TrEMBL
      D4AEL8
      Conserved Domains (2) summary
      PTZ00121
      Location:213 → 879
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:657 → 963
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version

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