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    Dnaaf3 dynein, axonemal, assembly factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100359753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnaaf3provided by RGD
    Official Full Name
    dynein, axonemal, assembly factor 3provided by RGD
    Primary source
    RGD:2323487
    See related
    EnsemblRapid:ENSRNOG00000038600 AllianceGenome:RGD:2323487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in axonemal dynein complex assembly and motile cilium assembly. Predicted to act upstream of or within determination of left/right symmetry and heart development. Predicted to be located in dynein axonemal particle. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 2. Orthologous to human DNAAF3 (dynein axonemal assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 380.0), Testes (RPKM 32.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnaaf3 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78333985..78342034)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69291300..69299365)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72874131..72882867)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, H Neighboring gene uncharacterized LOC108349515 Neighboring gene synaptotagmin 5 Neighboring gene troponin I3, cardiac type Neighboring gene troponin T1, slow skeletal type

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia. Mitchison HM, et al. Nat Genet, 2012 Mar 4. PMID 22387996, Free PMC Article
    2. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    4. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in dynein axonemal particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal assembly factor 3
    Names
    Dynein assembly factor 3, axonemal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271115.1 → NP_001258044.1  dynein axonemal assembly factor 3

      See identical proteins and their annotated locations for NP_001258044.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D3ZCM9
      Conserved Domains (3) summary
      PTZ00436
      Location:463 → 579
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      pfam14737
      Location:16 → 122
      DUF4470; Domain of unknown function (DUF4470)
      pfam14740
      Location:154 → 434
      DUF4471; Domain of unknown function (DUF4471)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78333985..78342034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588635.3 → XP_017444124.1  dynein axonemal assembly factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QR42
      Related
      ENSRNOP00000055687.4, ENSRNOT00000058900.6

    2. XM_039101466.2 → XP_038957394.1  dynein axonemal assembly factor 3 isoform X1

      Conserved Domains (3) summary
      PTZ00436
      Location:533 → 657
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      pfam14737
      Location:60 → 187
      DUF4470; Domain of unknown function (DUF4470)
      pfam14740
      Location:219 → 499
      DUF4471; Domain of unknown function (DUF4471)

    3. XM_039101524.2 → XP_038957452.1  dynein axonemal assembly factor 3 isoform X3

      Conserved Domains (3) summary
      PTZ00436
      Location:489 → 611
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      pfam14737
      Location:16 → 143
      DUF4470; Domain of unknown function (DUF4470)
      pfam14740
      Location:175 → 455
      DUF4471; Domain of unknown function (DUF4471)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZCM9.1 GenPept UniProtKB/Swiss-Prot:D3ZCM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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