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    Lrrc32 leucine rich repeat containing 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc32provided by RGD
    Official Full Name
    leucine rich repeat containing 32provided by RGD
    Primary source
    RGD:1309087
    See related
    EnsemblRapid:ENSRNOG00000015310 AllianceGenome:RGD:1309087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Garp
    Summary
    Predicted to enable receptor ligand inhibitor activity and transforming growth factor beta binding activity. Predicted to be involved in establishment of protein localization to extracellular region; secondary palate development; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within negative regulation of activated T cell proliferation; negative regulation of cytokine production; and positive regulation of gene expression. Predicted to be located in cell surface and nucleoplasm. Predicted to be active in extracellular space. Orthologous to human LRRC32 (leucine rich repeat containing 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 33.2), Lung (RPKM 30.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc32 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (162196995..162209563)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (152785709..152802997)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163443972..163457426)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene thioredoxin 1 like 1 Neighboring gene guanylate cyclase 2E Neighboring gene uncharacterized LOC134484907 Neighboring gene tubulin, alpha 1C, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. Stockis J, et al. Eur J Immunol, 2009 Dec. PMID 19750484
    2. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Tran DQ, et al. Proc Natl Acad Sci U S A, 2009 Aug 11. PMID 19651619, Free PMC Article
    3. Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis. Wu BX, et al. J Biol Chem, 2017 Nov 3. PMID 28912269, Free PMC Article
    4. GARP regulates the bioavailability and activation of TGFβ. Wang R, et al. Mol Biol Cell, 2012 Mar. PMID 22278742, Free PMC Article
    5. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. Wang R, et al. PLoS One, 2008 Jul 16. PMID 18628982, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor ligand inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in secondary palate development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transforming growth factor beta activator LRRC32
    Names
    glycoprotein A repetitions predominant
    leucine-rich repeat-containing protein 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170434.3 → NP_001163905.1  transforming growth factor beta activator LRRC32 precursor

      See identical proteins and their annotated locations for NP_001163905.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I6E0, D3ZVD5
      Related
      ENSRNOP00000020520.3, ENSRNOT00000020520.7
      Conserved Domains (3) summary
      PLN00113
      Location:123 → 575
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:55 → 75
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:55 → 278
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      162196995..162209563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229747.5 → XP_006229809.1  transforming growth factor beta activator LRRC32 isoform X2

      See identical proteins and their annotated locations for XP_006229809.1

      UniProtKB/TrEMBL
      A6I6E0, D3ZVD5
      Conserved Domains (3) summary
      PLN00113
      Location:123 → 575
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:55 → 75
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:55 → 278
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_063285048.1 → XP_063141118.1  transforming growth factor beta activator LRRC32 isoform X3

    3. XM_039106013.2 → XP_038961941.1  transforming growth factor beta activator LRRC32 isoform X2

      UniProtKB/TrEMBL
      A6I6E0, D3ZVD5
      Conserved Domains (3) summary
      PLN00113
      Location:123 → 575
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:55 → 75
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:55 → 278
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. XM_006229746.5 → XP_006229808.1  transforming growth factor beta activator LRRC32 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYB9
      Related
      ENSRNOP00000083930.1, ENSRNOT00000098962.2
      Conserved Domains (3) summary
      cd00116
      Location:82 → 305
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:82 → 102
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:177 → 237
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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