GEO DataSets

(Submitter supplied) Trisomy of human chromosome 21 (T21) gives rise to Down syndrome, the most frequent life-born autosomal aneuploidy. To enable in vitro analyses of the cellular and moelcular mechanisms leading to the neurological alterations associated with T21, we created and characterized a panel of genomically diverse T21 and euploid induced pluripotent stem cells (iPSCs) from fibroblasts obtained from the Coriell Institute for Biomedical Research, and we then differentiated these iPSCs into neural progenitor cells (NPCs). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

51 Samples

Download data: CEL

(Submitter supplied) In tumorous conditions, the transcription factor STAT1, traditionally recognized for its anti-tumor role in immunology, exhibits pro-survival characteristics, though the underlying mechanisms remain unclear. Investigating STAT1's function in isogenic colorectal tumor cells with wild-type or mutant KRAS, we found that STAT1 specifically promotes the survival and proliferation of cells with mutant KRAS. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

16 Samples

Download data: CEL

(Submitter supplied) A mouse bearing a xenograft derived from the bladder cancer cell line HT1376 was administered the hypoxia-targeted compound pimodidazole. Gene expression data was derived from samples microdissected from 3 regions of pimonidazole enriched staining and 3 regions with low pimonidazole staining.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

6 Samples

Download data: CEL

(Submitter supplied) Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high risk of recurrence following treatment. Inhibition of cysteine uptake by erastin effectively induces mesenchymal TNBC undergoing prompt ferroptosis. However, a small residual population of cancer cells keeps resistant and survived during the erastin treatments, which might mimic tumor relapse in patients after therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

6 Samples

Download data: CEL

(Submitter supplied) We observed human colorectal cancer cell lines obtained resistance under treatment, and resistant cells switched back to sensitive state when the treatment is withdrawn. To understand gene expressions change during this process, we performed Affymetrix experiments for parental, R20 (resistant), and W20 (withdrawal treatment) clones for three colorectal cancer cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

27 Samples

Download data: CEL, CHP

(Submitter supplied) As humans age, their memory T cell compartment expands due to the lifelong exposure to antigens. This expansion is characterized by the presence of terminally differentiated CD8+ T cells (Temra), which possess NK cell-like phenotype and are associated with chronic inflammatory conditions. Temra cells are predominantly driven by the sporadic reactivation of cytomegalovirus (CMV), yet their epigenomic patterns and cellular heterogeneity remain understudied. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

91 Samples

Download data: CEL

(Submitter supplied) In this data set we aimed to interrogate the milestones of human functional gut development from 13-20 weeks post gestation for proximal intestinal segments and 15-35 weeks gestation for distal intestinal segments

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

45 Samples

Download data: CEL

(Submitter supplied) The signal transducer and activator of transcription 3 (STAT3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (Y705) or serine 727 (S727) residues that regulates essential processes such as cell differentiation, apoptosis inhibition, or cell survival. we used microarrays to evaluate the effects of the STAT3 phosphomutants on global gene expression and identify the genes and pathways regulated by different STAT3 phosphorylation states in the 769-P cell line.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

45 Samples

Download data: CEL

(Submitter supplied) Transcriptomic profile study comparing human acute leukemia derived cell lines HL-60 and OCI-AML3 treated with the antitumoral peptide CIGB-300 at 30min and at 3h. CIGB-300 is an antitumoral peptide that blocks CK2 phospho-acceptor sites on their substrates but it also binds to CK2α catalytic subunit. This peptide has demonstrated their antiproliferative effects on different models including acute leukemia cells and also their antitumoral action in animal models and in clinical assays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

23 Samples

Download data: CEL

(Submitter supplied) Skin melanomas are highly aggressive and metastatic. Omomyc is the best MYC inhibitor currently available. We analysed the effect of Omomyc expression in a transgenic and inducible (upon Doxycycline addition) manner in melanoma cells in vivo in two different melanoma cell lines: A375 (mutated in BRAF), SkMel147 (mutated in NRAS). We used microarrays to detail the change in the gene expression programs induced by Omomyc on day 7.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

8 Samples

Download data: CEL

(Submitter supplied) Skin melanomas are highly aggressive and metastatic. Omomyc is the best MYC inhibitor currently available. We analysed the effect of Omomyc expression in a transgenic and inducible (upon Doxycycline addition) manner in melanoma cells in vivo in two different melanoma cell lines: A375 (mutated in BRAF), SkMel147 (mutated in NRAS). We used microarrays to detail the change in the gene expression programs induced by Omomyc on day 7.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

10 Samples

Download data: CEL

(Submitter supplied) Skin melanomas are highly aggressive and metastatic. Omomyc is the best MYC inhibitor currently available. We analysed the effect of Omomyc expression in a transgenic and inducible (upon Doxycycline addition) manner in melanoma cells in vitro in A375 (mutated in BRAF) melanoma cell line. We used microarrays to detail the change in the gene expression programs induced by Omomyc on day 4.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

10 Samples

Download data: CEL

(Submitter supplied) We sought to determine skeletal muscle genome-wide DNA methylation and transcriptome changes to one bout of lower-load (LL) versus higher-load (HL) resistance exercise. Previously trained college-aged males (n=11, age: 23±4 years old, training experience: 4 ± 3 years) performed LL or HL bouts to failure separated by one week. The HL bout (a.k.a., 80 Fail) consisted of four sets of back squats and four sets of leg extensions to failure using 80% of their estimated one-repetition maximum (i.e., est. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

64 Samples

Download data: CEL

(Submitter supplied) To test the effects of miR-4707-3p expression on gene expression and differentiation of primary human neural progenitor cells (phNPCs), we produced two doxycycline inducible stable cell lines using lentiviral transduction. Lines expressed either mir-4707 and GFP or only GFP using the pTRIPZ expression vector. Stable lines were grown in differentiation media with doxycycline for one or two weeks before RNA was extracted and assayed on a Clariom S Pico Microarray Assay.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

24 Samples

Download data: CEL

(Submitter supplied) Gene signatures based on the median expression of a preselected set of genes can provide prognostic and treatment outcome prediction and so be valuable clinically. Different health care services use different gene expression platforms to derive gene expression data. Here we have derived gene expression data using a microarray platform.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

171 Samples

Download data: CEL

(Submitter supplied) To examine the broad impact of IL-27 on human astrocytes, we performed a microarray analysis assessing >20,000 well annotated genes on primary astrocytes culture from four fetal brain donors. Astrocytes were inflamed or not using human recombinant IL-1 beta (20 ng/mL) befor being exposed or not to human recombinant IL-27 (100 ng/mL). Our goal was to investigate the impact of interleukin-27 on the gene expression profil of human astrocytes

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

16 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; synthetic construct

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL24324 GPL19117

28 Samples

Download data: CEL

(Submitter supplied) Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) are a promising disease model, although hPSC-CMs are not fully mature cardiomyocytes. We examined exponential differentially expressed miRNA/gene to identify critical time-regulated transcripts associated with hPSC-CM differentiation. We uncovered 324 interactions among 29 differentially expressed genes and 51 miRNAs from 20.543 transcripts during the 120 days of hPSC-CM differentiation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

14 Samples

Download data: CEL

(Submitter supplied) Idelalisib is a phosphatidylinositol 3-delta kinase inhibitor that has shown good efficacy in treating some hematologic malignancies. Rare, but potentially serious liver toxicity was associated with idelalisib use in clinical trials. The objective of this study was to evaluate the idelalisib-induced activation of stress response pathways in human hepatocytes to inform mechanisms of liver injury observed in the clinic Primary human hepatocytes from three donors were sandwich cultured and assayed for global gene expression across 5 concentrations of idelalisib after a 24 h exposure. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

24 Samples

Download data: CEL

(Submitter supplied) Infection with oncogenic human papillomavirus (HPV) is a major cause for the development of cervical cancer, which is mainly driven by the expression of the HPV E6 and E7 oncoproteins. We uncovered that the concentration levels of the putative tumor suppressor Dickkopf-1 (Dkk1) are restricted in cervical cancer cells by HPV E6 expression due to the E6-mediated proteolytic degradation of p53, which is a transcriptional regulator of Dkk1. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

12 Samples

Download data: CEL