GEO DataSets

(Submitter supplied) Effect of DB818 treatment on murine Hoxa9-transformed MigA9 cell line Effect of DB818 treatment on murine Hoxa9-transformed MigA9 cell line

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

3 Samples

Download data: TXT

(Submitter supplied) BACKGROUND: Hepatocellular carcinoma (HCC) is a common complication of chronic viral hepatitis. In support of this notion, we have reported that hepatitis B surface antigen (HBsAg)-specific CD8+ T lymphocytes critically contribute to inducing chronic liver cell injury that exerts high carcinogenic potential in a hepatitis B virus (HBV) Tg mouse model. The dynamics of the molecular signatures responsible for hepatocellular carcinogenesis are not fully understood. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

45 Samples

Download data: TXT

(Submitter supplied) In order to investigate the mechanisms underlying defective alveologenesis caused by RANK over-expression in mice, global gene expression profiles from primary acinar cultures of mammary epithelial cells were analyzed.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

72 Samples

Download data: TXT

(Submitter supplied) Microarray gene profiling of thymus from PLA2G10-Tg mice in comparison with that from control mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

2 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling was performed using the total RNA isolated from pooled esophagi (plural of esophagus) of embryonic day 15.5 (E15.5) C57BL/6 mouse embryos and total RNA isolated from pooled esophagi of postnatal day 2 (P2) C57BL/6 pups. The goal was to identify differentially regulated genes in these two separate developmental stages.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

1 Sample

Download data: TXT

(Submitter supplied) Pla2g2f is dominantly expressed in the suprabasal layer of mouse epidermis. Microarray gene profiling supported the overall tendency of epidermal and sebaceous gland hyperplasia as well as alopecia in Pla2g2f-transgenic skin.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

2 Samples

Download data: TXT

(Submitter supplied) Microarray gene profiling of skin from PLA2G10-Tg mice in comparison with that from control mice yielded data for explaining the overall tendency of Tg skin to show hair follicle distortion and epidermal hyperplasia associated with hyperkeratosis in the absence of inflammation

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

2 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL2872 GPL4134

31 Samples

Download data: GPR

(Submitter supplied) Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to identify genetic hallmarks of early steps of reward memory in basal ganglia including accumbens nucleus (NAc), globus pallidus (GP) and subthalamic nucleus (STN). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

8 Samples

Download data: GPR

(Submitter supplied) Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to identify genetic hallmarks of early steps of reward memory in basal ganglia including accumbens nucleus (NAc), globus pallidus (GP) and subthalamic nucleus (STN). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

5 Samples

Download data: GPR

(Submitter supplied) Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to identify genetic hallmarks of early steps of reward memory in basal ganglia including accumbens nucleus (NAc), globus pallidus (GP) and subthalamic nucleus (STN). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

10 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL2872 GPL10333 GPL7732

30 Samples

Download data: TXT

(Submitter supplied) Mouse B cell precursors from fetal liver and adult bone marrow generate distinctive B cell progeny when transplanted into immunodeficient recipients, supporting a two-pathway model for B lymphopoiesis, fetal “B-1” and adult “B-2”. Recently Lin28b was shown to be important for the switch between fetal and adult pathways; however, neither the mechanism of Lin28b action nor the importance of BCR signaling in this process was addressed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

16 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of mouse ventricular tissue comparing WT control mice with mice invalidated (KO) for AMPK-alpha 2 gene. Goal was to identify new biological targets of AMPK in heart, through a global gene expression approach.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

12 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of mouse cortex tissue comparing control animals with Gtf2i-mutated mouse (Gtf2i+/Δex2 ). Goal was to determine the specific deregulated genes in the cortex of mutated animals.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

3 Samples

Download data: TXT

(Submitter supplied) This study assessed gene expression changes associated with inflammation in the colon tissue of multi-drug resistance targeted mutation (Mdr1a-/-) mice, a model of human IBD. It also tested the anti-inflammatory potential of curcumin in the colon of these mice with a particular focus on the proteome. A colonic histological injury score was determined for each mouse to assess the level of colon inflammation in Mdr1a-/- mice, and to establish the effect of curcumin on inflammation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

8 Samples

Download data: CSV, GPR, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2872 GPL4133

10 Samples

Download data: TXT

(Submitter supplied) We investigated the gene expression of the mouse CPE. We isolated CPE cells from three mouse brains with laser dissection microscopy. Next, we performed RNA isolation, amplification, labeling and hybridization against 44k Agilent microarrays.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

3 Samples

Download data: TXT

(Submitter supplied) Although ERBB2 amplification and overexpression is correlated with poor outcome in breast cancer, the molecular mechanisms underlying the aggressive nature of these tumors has not been fully elucidated. To investigate this further, we have used a transgenic mouse model of ErbB2-driven tumor progression (ErbB2KI model) that recapitulates clinically relevant events, including selective amplification of the core erbB2 amplicon. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6585 GPL2872

18 Samples

Download data: TXT

(Submitter supplied) The mechanisms by which the early spatiotemporal expression patterns of transcription factors such as Pax6 regulate the region-specific proliferation rates of neural progenitors are poorly understood. Pax6 is expressed in a gradient across the developing cortex and is essential for normal corticogenesis. We found that constitutive or conditional loss of Pax6 increases cortical progenitor proliferation by amounts that vary regionally with normal Pax6 levels. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

3 Samples

Download data: TXT