GEO DataSets

Analysis of mammary gland from parous or virgin Lewis animals 3 weeks after treatment with 50 mg/kg of N-methyl-N-nitrosourea, a carcinogen. Full-term pregnancy early in life is associated with a reduced chance of developing breast cancer.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 development stage sets

Platform:

GPL890

Series:

GSE2726

4 Samples

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(Submitter supplied) Early full-term pregnancy affords lifetime protection against development of breast cancer. Parity-induced protection can be reproduced in a carcinogen-induced rat mammary carcinoma model. The molecular mechanisms of parity-induced protection against carcinogenic stimuli in rat mammary glands have not been fully characterized. In order to gain a better understanding of these molecular mechanisms, we performed gene expression analyses in parous and age-matched virgin (AMV) mammary glands of Lewis rats before and after carcinogen (N-methyl-N-nitrosourea; MNU) treatment. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1422

Platform:

GPL890

4 Samples

Download data

(Submitter supplied) Characterizing estrogen-responsive genes is an essential step towards fully understanding mechanisms of estrogen action during mammary gland development and function. To catalogue these genes, sixteen prepubertal heifers were used in a 2 x 2 factorial with ovarian status (intact or ovariectomized) as the first factor and estrogen treatment as the second (control or estradiol). Heifers were ovariectomized at approximately 4.5 months of age and estrogen treatments were initiated one month later. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL3711

32 Samples

Download data: CEL

(Submitter supplied) Childhood exposure to carcinogens renders a higher risk of breast cancer. The molecular mechanisms underlying cancer development after such exposure are not, however, well understood. Here we examined how the mechanism of cancer development relates to the age at exposure to ionizing radiation (IR) or the carcinogen 1-methyl-1-nitrosourea (MNU). Pre- and postpubertal (3- and 7-week-old, respectively) female Sprague-Dawley rats were whole-body gamma-irradiated (2 Gy), injected intraperitoneally with MNU (20 mg/kg) or left untreated and were autopsied at 50 weeks of age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

13 Samples

Download data: TXT

(Submitter supplied) Spontaneous mammary tumours are the most prevalent type of neoplasm in women as well as in female dogs. Even though ovarian hormones, mainly estrogens and progestins, are known to play a key role in mammary tumorigenesis, conflicting reports have been obtained from in vivo and in vitro studies concerning their role, especially of progestins, in mammary tumorigenesis. Prolonged exposure to high levels of progestins during unusually long luteal phase of oestrous cycle is suspected to be the key event in canine mammary tumorigenesis. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL5117

37 Samples

Download data: TXT

(Submitter supplied) Rat mammary tumors induced by N-methyl-N-nitrosurea (NMU) and normal mammary gland Keywords = breast cancer Keywords = rat mammary tumor Keywords = NMU Keywords = animal model. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1363

Platform:

GPL341

35 Samples

Download data: CEL

Analysis of N-methyl-N-nitrosourea (NMU)- induced primary mammary tumors from Wistar-Furth females. Results compared to expression profiles of human breast carcinomas, and found similar to profiles of ER-positive, low to intermediate grade breast cancer.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE1872

35 Samples

Download data: CEL

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

16 Samples

Download data: CEL, EXP

(Submitter supplied) The role of diet in the prevention of breast cancer is widely accepted, yet little is known on how early dietary effects mitigate adult cancer risk. Soy consumption is associated with reduced breast cancer risk in women, an effect largely attributed to the soy isoflavone genistein (GEN). We previously showed lower chemically-induced mammary tumor incidence in young adult rats with lifetime dietary intake of soy protein isolate (SPI), a highly refined soy product in infant formula, than in those fed the control diet Casein (CAS). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2616

Platform:

GPL341

10 Samples

Download data: CEL

Analysis of mammary epithelial cells of females fed a diet containing the soy isoflavone genistein or soy protein isolate. Soy consumption is associated with reduced breast cancer risk in women. Results provide insight into the molecular basis of the beneficial effect of soy-rich diets.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol sets

Platform:

GPL341

Series:

GSE6879

10 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

43 Samples

Download data: CEL

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profile of total isolated mammary epithelial cells in mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

8 Samples

Download data: CEL

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profiles of stromal and various epithelial mammary cell subpopulations in mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

35 Samples

Download data: CEL

(Submitter supplied) A series of experiments to establish a bovine developing mammary gland gene expression signature, identify genes differentially expressed in bovine lactating mammary gland, and to establish the false positive rate of the BMAM microarray Keywords = gene expression, differential expression, lactation, development, physiology, bovine, mammary, microarray, EST, cDNA Keywords: repeat sample

Organism:

Bos taurus

Type:

Expression profiling by array

Dataset:

GDS205

Platform:

GPL245

13 Samples

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Variety of bovine tissues hybridized against the bovine mammary (BMAM) array. Reference is bovine macrophage (BovMac) cell line. Contribution towards development of a mammary gland gene expression profile.

Organism:

Bos taurus

Type:

Expression profiling by array, log ratio, 9 tissue sets

Platform:

GPL245

Series:

GSE279

10 Samples

Download data

(Submitter supplied) Similar to the bone marrow, the mammary gland contains a distinct population of Hoechst-effluxing side population cells, MG-SPs. To better characterize MG-SPs, their microarray gene profiles were compared to the remaining cells, which retain Hoechst dye (MG-NSPs). For analysis, gene ontology (GO) that describes genes in terms of biological processes and ontology traverser (OT) that performs enrichment analysis were utilized. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2157

Platform:

GPL1261

7 Samples

Download data: CEL, XLS

Analysis of Hoechst dye 33342-effluxing side population cells (SPs) from the mammary glands of 4 to 6 week old C57/BL6 virgins. Results provide insight into the stem cell potential of mammary gland SPs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 specimen sets

Platform:

GPL1261

Series:

GSE5309

7 Samples

Download data: CEL

(Submitter supplied) Pregnancy has been shown to decrease the risk of mammary carcinogenesis in human rretrospective epidemiological studies. In rodents, pregnancy prior to carcinogen administration or after carcinogen challenge has also been shown to reduce the incidence of palpable carcinomas. In this study our objective to determine the underlying genomic signature of the pregnancy and reproductive hormones on the mammary gland that contribute to the protection against mammary gland carcinogenesis. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4081

Platform:

GPL1355

15 Samples

Download data: CEL, TXT

Analysis of mammary gland of metestrus Lewis females randomly assigned to 3 groups: control, pregnancy, or hormone (exogenous estrogen and progesterone). Full-term pregnancy or treatment with hormone reduces breast cancer risk. Results provide insight into molecular basis of the protective effect.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 2 development stage, 3 protocol sets

Platform:

GPL1355

Series:

GSE32125

15 Samples

Download data: CEL

(Submitter supplied) Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body γ radiation and mammary glands were surgically removed 2-month after radiation. RNA was isolated and microarray hybridization performed for gene expression analysis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

5 Samples

Download data: TXT