GEO DataSets

(Submitter supplied) In eukaryotic cells , histone deactylase plays key roles in the diverse process such as genomic stabillity, differenciation, and metabolism. These enzymes also conserved in filamentous fungi, and their functios has been started to understand some fungal biological process such as development, stress responce, and secondary metabolism. We found deletion of HstD homolog of yeast Hst4, affected development, secondary metabolism in aspergillyus oryzae. more...

Organism:

Aspergillus oryzae RIB40; Aspergillus oryzae

Type:

Expression profiling by array

Platform:

GPL16184

4 Samples

Download data: CEL, CHP

(Submitter supplied) The sirA gene encodes a member of sirtuin protein that is NAD(+)-dependent histone deacetylase (HDAC) and ubiquitous in eukaryote. DNA microarray analyses for Aspergillus nidulans FGSCA26 (WT) strain and Gene disruptant of sirA (SirAd) indicated that genes for synthesizing secondary metabolic products such as sterigmatocystin, penicillin G, emericellamide, aspernidine A, xanthone, austinol, and siderophores are down-regulated by SirA.

Organism:

Aspergillus nidulans

Type:

Expression profiling by array

Platform:

GPL10798

6 Samples

Download data: CEL, CHP

(Submitter supplied) Expression profiling, ChiP-CHIP and phenotypic analysis were used to investigate the functional relationships of class III NAD+-dependent HDACs (Sirtuins) in fission yeast. We detected significant histone acetylation increases in Sirtuin mutants at their specific genomic binding targets and were thus able to identify an in vivo substrate preference for each Sirtuin. At heterochromatic loci, we demonstrate that although Hst2 is mainly cytoplasmic, a nuclear pool of Hst2 co-localises with the other Sirtuins at silent regions (cen, mat, tel, rDNA) and that like the other Sirtuins, Hst2 is required for rDNA and centromeric silencing. more...

Organism:

Schizosaccharomyces pombe

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

6 related Platforms

77 Samples

Download data: TXT

(Submitter supplied) The mitosporic fungus Trichoderma reesei is an industrial producer of enzymes for degradation of lignocellulosic polysaccharides to soluble monomers that can be fermented to biofuels. The genes encoding these enzymes in T. reesei have recently been shown to be clustered in the genome. Here we will show that the expression of these genes is epigenetically controlled at the heterochromatin level by the protein methyltransferase LAE1. more...

Organism:

Trichoderma reesei

Type:

Expression profiling by array

Platform:

GPL10642

8 Samples

Download data: CALLS, PAIR, TXT

(Submitter supplied) LaeA, a putative methyltransferase, is a global regulator for metabolic and development process in filamentous fungi. We characterized the laeA homologous genes in the white koji fungus, Aspergillus luchuensis mut. kawachii (A. kawachii) to examine their role in citric acid production. The ΔlaeA strain showed a significant reduction in the citric acid productivity. The cap-analysis gene expression (CAGE) revealed the laeA is required for the gene expression of a putative citrate exporter encoding cexA, which has a critical role for the citric acid production. more...

Organism:

Aspergillus luchuensis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26777

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Aspergillus nidulans

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL32392 GPL20839

21 Samples

Download data: TXT

(Submitter supplied) In the filamentous fungus Aspergillus nidulans, the velvet family protein VeA and the global regulator of secondary metabolism LaeA govern fungal development and secondary metabolism mostly by acting as the VelB/VeA/LaeA heterotrimeric complex. While functions of these highly conserved controllers have been well studied, the genome-wide regulatory networks governing cellular and chemical development remain to be uncovered. more...

Organism:

Aspergillus nidulans

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL20839

12 Samples

Download data: TXT

(Submitter supplied) In the filamentous fungus Aspergillus nidulans, the velvet family protein VeA and the global regulator of secondary metabolism LaeA govern fungal development and secondary metabolism mostly by acting as the VelB/VeA/LaeA heterotrimeric complex. While functions of these highly conserved controllers have been well studied, the genome-wide regulatory networks governing cellular and chemical development remain to be uncovered. more...

Organism:

Aspergillus nidulans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32392

9 Samples

Download data: TXT

(Submitter supplied) Expression profiles of wild-type and mcrA-deleted cells cultured in a glucose minimal medium for 1 day.

Organism:

Aspergillus nidulans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22359

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Aspergillus nidulans

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL20839

7 Samples

Download data: TXT

(Submitter supplied) In filamentous fungi, asexual sporulation involves morphological differentiation and metabolic changes. The process of asexual spore formation is tightly regulated by a variety of transcription factors including VosA, VelB, and WetA. A number of studies have demonstrated that these three transcription factors are key regulators of asexual spore formation and maturation in the model filamentous fungus Aspergillus nidulans. more...

Organism:

Aspergillus nidulans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20839

3 Samples

Download data: TXT

(Submitter supplied) In filamentous fungi, asexual sporulation involves morphological differentiation and metabolic changes. The process of asexual spore formation is tightly regulated by a variety of transcription factors including VosA, VelB, and WetA. A number of studies have demonstrated that these three transcription factors are key regulators of asexual spore formation and maturation in the model filamentous fungus Aspergillus nidulans. more...

Organism:

Aspergillus nidulans

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL20839

4 Samples

Download data: NARROWPEAK

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Aspergillus nidulans; Aspergillus fumigatus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL23160 GPL20839

8 Samples

Download data: TXT

(Submitter supplied) Asexual development is fundamental to the ecology and lifestyle of filamentous fungi and can facilitate both plant and human infection. In the filamentous fungal genus Aspergillus, the production of asexual spores is primarily governed by the BrlA-AbaA-WetA central regulatory cascade. The final step in this cascade, which is controlled by the WetA protein, not only governs cellular development (i.e., the morphological differentiation of spores) but also ensures its coupling with chemical development (i.e., the coordinated production and deposition of diverse secondary metabolites, such as aflatoxins, into spores). more...

Organism:

Aspergillus nidulans; Aspergillus fumigatus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL20839 GPL23160

4 Samples

Download data: TXT

(Submitter supplied) Asexual development is fundamental to the ecology and lifestyle of filamentous fungi and can facilitate both plant and human infection. In the filamentous fungal genus Aspergillus, the production of asexual spores is primarily governed by the BrlA-AbaA-WetA central regulatory cascade. The final step in this cascade, which is controlled by the WetA protein, not only governs cellular development (i.e., the morphological differentiation of spores) but also ensures its coupling with chemical development (i.e., the coordinated production and deposition of diverse secondary metabolites, such as aflatoxins, into spores). more...

Organism:

Aspergillus nidulans

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL20839

4 Samples

Download data: NARROWPEAK

(Submitter supplied) The cell wall is a structure involved in important stages of fungal growth and morphogenesis. Several studies in the literature have shown how perturbations at the cell wall-level trigger dramatic effects on growth (e.g. Horiuchi, 2009). Despite the importance of fungal cell walls and despite the great advances made in the field, there are still missing pieces in our understanding of cell wall dynamics in filamentous fungi. more...

Organism:

Aspergillus nidulans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22359

6 Samples

Download data: TXT

(Submitter supplied) Glutathione (GSH) is an abundant and widely distributed antioxidant in fungi. Hence, understanding cellular GSH metabolism is of vital importance to deciphering redox regulation in these microorganisms. In this study, we generated dugB (AN1879), dugC (AN1092), and dugB dugC double deletion mutants which display disruption of the GSH degradation pathway in Aspergillus nidulans. Deletion of dugB, dugC or both resulted in a moderate increase in GSH content under growing conditions and substantially slowed down the depletion of GSH pools under carbon starvation. more...

Organism:

Aspergillus nidulans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28598

12 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Thermothelomyces thermophilus ATCC 42464

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:

GPL30625 GPL32675

36 Samples

Download data: TDF, TXT

(Submitter supplied) The low efficiency of fungal growth and substrate utilization is a barrier to high yield and productivity of target products during fungal fermentation. However, elaborated and intricate regulatory mechanisms of fungal growth remains inconclusive. In this study, we found deletion of putative methyltransferase LaeA enhanced sugar consumption and fungal growth rate of M. thermophila. The exploration of the mechanism of LaeA regulation revealed that transcription factor (Cre-1, Grf-1, Grf-2 and Grf-3) acted as negative repressor of intracellular metabolism, of which expression was indirectly regulated by LaeA. more...

Organism:

Thermothelomyces thermophilus ATCC 42464

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL32675

4 Samples

Download data: TXT

(Submitter supplied) The low efficiency of fungal growth and substrate utilization is a barrier to high yield and productivity of target products during fungal fermentation. However, elaborated and intricate regulatory mechanisms of fungal growth remains inconclusive. In this study, we found deletion of putative methyltransferase LaeA enhanced sugar consumption and fungal growth rate of M. thermophila. The exploration of the mechanism of LaeA regulation revealed that transcription factor (Cre-1, Grf-1, Grf-2 and Grf-3) acted as negative repressor of intracellular metabolism, of which expression was indirectly regulated by LaeA. more...

Organism:

Thermothelomyces thermophilus ATCC 42464

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL32675

8 Samples

Download data: TDF, TXT