GEO DataSets

(Submitter supplied) Cows exposed to short day photoperiod (SD, 8L:16D) during the 60-day non-lactating period prior to parturition produce more milk in their subsequent lactation compared to cows exposed to long day photoperiod (LD,16L:8D). Although this response is well-established in dairy cows, the underlying mechanisms are not understood. We hypothesized that differential gene expression in cows exposed to SD or LD photoperiods during the dry period could be used to identify the functional basis for the subsequent increase in milk production during lactation. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL2112

14 Samples

Download data: CEL

(Submitter supplied) Data from one animal from B9_B12 group (Cow 31) were not taken into account for the liver samples Treated animals were compared to control (non supplemented cows)

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL11648

25 Samples

Download data: TXT

(Submitter supplied) Our previous studies found circadian disruption increased insulin resistance and decreased mammary development in late pregnant cows. The effect of circadian disruption on liver and mammary transcriptomes was measured to understand how it impacted hepatic function and mammary development. At 35 d before expected calving (BEC) multiparous Holstein cows were assigned to either control (CON) or phase-shifted treatments (PS). more...

Organism:

Bos taurus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15749

24 Samples

Download data: CSV

(Submitter supplied) Developmental programming is the concept that environmental factors, particularly during foetal life, can alter development, metabolism and physiology of an organism and this can have consequences later in life. There is growing interest in developmental programming in livestock species, particularly effects of maternal pregnancy nutrition, which is easy to manipulate. Recent research, using a sheep model, has shown that milk production in ewe offspring may be susceptible to maternal nutritional programming, such that over nutrition (ad libitum) of the pregnant dam, compared with maintenance nutrition, may impair their first lactation performance and result in the weaning of lighter lambs. more...

Organism:

Ovis aries

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15670

15 Samples

Download data: CSV

(Submitter supplied) The bovine dry period is a dynamic non-lactating phase where the mammary gland undergoes extensive tissue remodeling. Utilizing RNA Sequencing, this study characterized novel genes and pathways involved in this process and determined the impact of dry period heat stress. Mammary tissues were collected before and during the dry period (-3, 3, 7, 14, and 25 days relative to dry-off) from twelve heat-stressed (HT, n=6) or cooled (CL, n=6) pregnant Holstein cows.

Organism:

Bos taurus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23055

60 Samples

Download data: TXT

(Submitter supplied) The purpose of the present study was to provide a comprehensive transcriptome profiling of mammary gland and to find the key differences in the milk production and related traits between Jersey and Kashmiri cattle. Casein and whey protein genes were found to be highly expressed throughout the lactation cycle. Largest differences in DEGs was reported between D15 and D90 with 1805 genes in Kashmiri cattle and between D15 and D250 with 3392 genes in Jersey cattle.

Organism:

Bos indicus; Bos taurus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19172 GPL19746

17 Samples

Download data: TXT

(Submitter supplied) To further delineate the genes and transcription regulators implicated in the control of the transition from colostrogenesis to lactogenesis, we applied RNA-seq analysis of swine mammary gland tissue from late-gestation to farrowing.

Organism:

Sus scrofa

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19176

15 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to determine the effects of unprotected dietary unsaturated fatty acids (UFA) from different plant oils on gene expression in the mammary gland of grazing dairy cows. Milk composition and gene expression in the mammary gland tissue were evaluated in grazing dairy cows supplemented with different unsaturated fatty acids (UFA). The UFA supplementation improves the health and nutrition quality aspects of dairy milk, but also affects the gene networks expression signature associated with cellular growth and proliferation, cell-death, signalling, nutrient metabolism, and immune response, and in turn, the mammary gland integrity and health. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL10186

55 Samples

Download data: CEL

(Submitter supplied) This study was performed to identify transcripts that are differentially expressed in the mammary gland at 4 stages of developmental (virgin, pregnant, lactating and involution) in wild type C57BL/6J mice. Keywords: developmental stage

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2360

Platform:

GPL81

9 Samples

Download data: CEL

Analysis of whole mammary glands (no.4 inguinal) of C57BL/6J animals during puberty, pregnancy, lactation, and involution. Mammary glands examined during puberty were obtained from virgins.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 development stage sets

Platform:

GPL81

Series:

GSE5831

9 Samples

Download data: CEL

(Submitter supplied) The objective was to evaluate the effect of nutrient restriction and intramammary lipopolysaccharide (LPS) challenge on mammary gland (MG) gene expression in early lactation cows. At 24 ± 3 d in milk, multiparous cows were either allowed to continue ad libitum intake of a lactation diet (CON, n = 6), or the ration was diluted with barley straw (48% DM) for 4 d (RES, n = 6). On d 3, one healthy rear mammary quarter was infused with 50 µg of LPS. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL11648

12 Samples

Download data: TXT

(Submitter supplied) The effects of a negative energy balance induced by a nutritional restriction on mammary gland were evaluated using the 4x44K bovine microarray from Agilent

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL11648

12 Samples

Download data: TXT

(Submitter supplied) Effect of feed restriction in mid lactation Holstein (H) and Montbéliarde (M) cows on mammary glande miRNA profil.

Organism:

Bos taurus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL23295

24 Samples

Download data: TXT

(Submitter supplied) Regulation of milk synthesis and secretion is controlled mostly through local (intra-mammary) mechanisms. To gain insight into the molecular pathways comprising this response, an analysis of mammary gene expression was conducted in 12 lactating cows shifted from twice daily to once daily milking. Tissues were sampled by biopsy from adjacent mammary quarters of these animals during the two milking frequencies, allowing changes in gene expression to be assessed within each animal. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL8618

12 Samples

Download data: TXT

(Submitter supplied) Liver and mammary gland are among the most prominent organs during lactation in dairy cows. With the purpose to understand 1) the adaptation of liver and mammary to different levels of forage/concentrate ration (60:40 vs. 40:60) and 2) the crosstalk between the two organs during lactation, a transcriptome analysis was performed on liver and mammary tissues of 10 primiparous dairy cows in mid-lactation. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL11649

20 Samples

Download data: TXT

(Submitter supplied) Bovine mammary gland provide the largest amount of milk for dairy industry to date. Insight in functional adaptation of this organ is critical in order to improve efficiency of milk synthesis and milk quality. In the present experiment microarray analysis in combination with bioinformatics tools was performed in mammary tissue from 8 Holstein cows during the entire lactation cycle.

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL9689

60 Samples

Download data: GPR

(Submitter supplied) Our overall objective is to identify key differences in gene expression signaling pathways in the epithelial and intralobular stromal compartments during prepartum mammary remodeling and development in the dry cow.

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL2112

12 Samples

Download data: CEL

(Submitter supplied) The role of chromatin in mammary gland development and differentiation has not been defined. Here we have studied the changes in chromatin conformation in the mammary gland during the lactation cycle at milk protein gene loci, whose gene expression marks functional differentiation of the mammary gland.

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL9250

12 Samples

Download data: TXT

(Submitter supplied) The role of chromatin in mammary gland development and differentiation has not been defined. Here we have studied the changes in chromatin conformation in the mammary gland during the lactation cycle at milk protein gene loci, whose gene expression marks functional differentiation of the mammary gland

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL9250

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Daphnia magna

Type:

Expression profiling by array

Platform:

GPL16579

60 Samples

Download data: TXT