Similar studies for GEO DataSets (Select 200106222) - GEO DataSets

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Items: 20

Select item 2001062221.

Presence of aggregates of smooth endoplasmic reticulum in MII oocytes affects oocyte development competence: a molecular-based evidence

(Submitter supplied) The oocytes presenting SERa are considered dysmorphic and have been associated with reduced embryological outcome and an increased risk of congenital anomalies. Therefore, in 2011 the Alpha/ESHRE Consensus strongly recommended not to inseminate MII oocytes displaying SERa (SERa+). Not all Centers follow this recommendation and some Authors reported that SERa+ can lead to healthy newborns. Moreover, no experimental data about the effect of SERa presence on the oocyte molecular status are available. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
6 Samples

Download data: TXT

Series

Accession:: GSE106222

ID:: 200106222

Select item 2000697682.

Storage time does not modify the gene expression profile of cryopreserved human metaphase II oocytes

(Submitter supplied) Study question: Does storage time impact on transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? Summary answer: For the first time, we demonstrate that the length of cryostorage has no effect on the gene expression profile of human metaphase II oocytes. What is known already: Oocyte cryopreservation is a largely-used technique in IVF for storage of surplus oocytes, as well as for fertility preservation (i.e., women undergoing gonadotoxic therapies) and oocyte donation programs. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
10 Samples

Download data: TXT

Series

Accession:: GSE69768

ID:: 200069768

Select item 2001643713.

The impact of ageing on the transition of the euploid human GV oocytes to in vivo matured MII oocytes

(Submitter supplied) Background: Early embryonic development is governed by maternal transcripts stored within the oocyte during oogenesis. Transcriptional activity of the oocyte ultimately dictates its developmental potential and may be influenced by maternal age, resulting in reduced competence of oocytes derived from women of advanced age, compared with the young. In the current study, RNA-Seq was used to perform transcriptome profiling of human GV and MII oocytes derived from young and advanced maternal age women. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
21 Samples

Download data: XLSX

Series

Accession:: GSE164371

ID:: 200164371

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000954774.

Transcriptome analysis of immature and matured human oocytes from patients of young and advanced maternal age

(Submitter supplied) Study Question: What effects do maternal age and oocyte maturation stage have on the human oocyte transcriptome that may be associated with oocyte developmental potential? Summary Answer: Although polyadenylated transcript abundance changes during human oocyte maturation irrespective of age, young (YNG) and advanced maternal age (AMA) metaphase II (MII) oocytes exhibit divergent transcriptomes. What is known already: Maternal age and maturation stage affect oocyte polyadenylated transcript abundance in human oocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
20 Samples

Download data: CSV

Series

Accession:: GSE95477

ID:: 200095477

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Select item 2000798865.

Bovine cumulus cells transcriptome in relation with oocyte chromatin configuration of the germinal vesicle

(Submitter supplied) Gene expression analysis in cc from COCs with different chromatin configuration (GV0-3)

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL13226
12 Samples

Download data: TXT

Series

Accession:: GSE79886

ID:: 200079886

Select item 2001278896.

Good quality day 7 embryos display disturbed cellular functions during post-hatching development when oocytes were matured under lipotoxic conditions: novel insights from a bovine embryo-transfer model

(Submitter supplied) Objective: To study post-hatching development after transfer of morphologically good quality embryos that survived in vitro maturation under lipolytic conditions using a well-established and recognized bovine model. Design: prospective study with a crossover design. Setting: research laboratory. Animals: 8 healthy multiparous non-lactating Holstein cows used in repeated embryo transfers. Intervention(s): Bovine cumulus oocyte complexes (COCs) were in vitro matured in the presence of either 1) a combination of elevated pathophysiological concentration of palmitic acid (PA) and physiological concentrations of stearic acid (SA) and oleic acid (OA) (HIGH PA), or 2) physiological concentrations of PA, SA and OA (BASAL). more...

Organism:: Bos taurus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22316
53 Samples

Download data: TXT

Series

Accession:: GSE127889

ID:: 200127889

PubMed Similar studies SRA Run Selector

Select item 2000447927.

Small RNA profiling of human cumulus cells and oocytes

(Submitter supplied) Cumulus cells are biologically distinct from other follicular cells and perform specialized roles, transmitting signals within the ovary and supporting oocyte maturation during follicular development. The bi-directional communication between the oocyte and the surrounding cumulus cells is crucial for the acquisition of oocyte competence. Using Illumina/deep-sequencing technology, we dissected the small RNAome of pooled human mature MII oocytes and cumulus cells.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL9115
2 Samples

Download data: TXT

Series

Accession:: GSE44792

ID:: 200044792

PubMed Similar studies SRA Run Selector

Select item 2000872018.

The transcriptome of human oocytes is related to age and ovarian reserve.

(Submitter supplied) Although it is well established that the ovarian reserve diminishes with increasing age, and that a woman’s age is correlated to lower oocyte quality, the interplay of a diminished reserve and age on oocyte developmental competence is not clear. After maturation, oocytes are mostly transcriptionally quiescent, and developmental competence prior to embryonic genome activation (EGA) relies on maternal RNA and proteins. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
35 Samples

Download data: CEL

Series

Accession:: GSE87201

ID:: 200087201

Select item 2001125369.

Transcriptome analysis of rhesus monkey germinal vesicle, failed-to-mature oocytes and MII oocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL23949 GPL19129
29 Samples

Download data: TXT

Series

Accession:: GSE112536

ID:: 200112536

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Select item 20011253410.

Transcriptome analysis of rhesus monkey MII oocytes

(Submitter supplied) Oocyte maturation defects are one contributing factor in unexplained female infertility. Failure of some oocytes to undergo germinal vesicle breakdown or progress to second meiotic metaphase in response to an ovulatory stimulus can limit the number of high quality oocytes available for assisted reproduction. Understanding the molecular mechanisms that underlie oocyte maturation failure may lead to novel methods for increasing the number of high quality oocytes available for assisted reproduction, as well as providing new insight into the basic biology of oocyte maturation. more...

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19129 GPL23949
11 Samples

Download data: TXT

Series

Accession:: GSE112534

ID:: 200112534

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011253311.

Transcriptome analysis of rhesus monkey germinal vesicle and failed-to-mature oocytes

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23949
18 Samples

Download data: TXT

Series

Accession:: GSE112533

ID:: 200112533

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015853912.

Transcriptome analysis of young human oocytes identifies a potential antioxidant to rescue unusable immature oocytes

(Submitter supplied) We highlighted the effects of age and ovarian responses on rescue IVM oocyte quality.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
21 Samples

Download data: TXT, XLSX

Series

Accession:: GSE158539

ID:: 200158539

PubMed Similar studies SRA Run Selector

Select item 20005285113.

Follicular cells in vivo and developmental competence of oocytes in human

(Submitter supplied) Transcriptional profiling of in vivo follicular cells from small (S), medium sized (M) and Large (L) follicles collected individually 36hrs post hCG in superstimulated women from fertility clinic. Samples are also characterized by their respective oocyte outcome following fertilization (transferable embryo (+) or not(-))

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10332
18 Samples

Download data: TXT

Series

Accession:: GSE52851

ID:: 200052851

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013386814.

Granulosa cell expression data from five different time points before and up to 36 hours after induction of ovulation in women receiving fertility treatment

(Submitter supplied) The process of ovulation includes oocyte meiotic maturation, follicle rupture and transformation of the follicle into a corpus luteum. These events are initiated by the midcycle surge of gonadotropins and require the coordinated regulation of thousands of genes. The aim of the study was to monitor the changes in granulosa cell gene expression across five different time points during the first 36 hours of ovulation until follicle rupture, in order to increase our understanding of the events of human ovulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
83 Samples

Download data: CEL, CHP

Series

Accession:: GSE133868

ID:: 200133868

PubMed Similar studies

Select item 20010890015.

The molecular characterisation of mitochondrial DNA deficient oocytes using a pig model

(Submitter supplied) Pig oocytes were stained with Brilliant cresyl blue to identify mtDNA deficient oocytes.

Organism:: Sus scrofa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24486
40 Samples

Download data: TXT

Series

Accession:: GSE108900

ID:: 200108900

PubMed Similar studies SRA Run Selector

Select item 20005679916.

Chromosome constitution in embryos generated after in vitro maturation in a culture system supplemented with cAMP modulators

(Submitter supplied) Ten volunteers underwent 13 research IVM cycles. Immature oocytes were retrieved after mild ovarian stimulation with gonadotropins but no hCG ovulation trigger, in vitro matured and fertilized using ICSI. Oocyte maturation rate in vitro was 47% (94/199), the mean fertilization rate was 71% (67/94) and 37% (25/67) of mature oocytes developed into a morphologically good quality embryo on day 3 after ICSI, after which the blastomeres were analysed by single-cell aCGH. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL17760
123 Samples

Download data: TXT

Series

Accession:: GSE56799

ID:: 200056799

Select item 20001203417.

The transcriptome of human oocytes

(Submitter supplied) The identification of genes and deduced pathways from the mature human oocyte can help us better understand oogenesis, folliculogenesis, fertilization, and embryonic development. Human metaphase II oocytes were used within minutes after removal from the ovary, and its transcriptome was compared with a reference sample consisting of a mixture of total RNA from 10 different normal human tissues not including the ovary. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3256
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE12034

ID:: 200012034

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 325618.

Metaphase II stage oocytes matured in vivo

Analysis of young, untreated metaphase II (MII) oocytes. Results provide insight into the baseline of genes expressed in in vivo matured oocytes and into the molecular mechanisms underlying biological processes such as oogenesis, folliculogenesis, fertilization, and embryonic development.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell type sets

Platform:: GPL570
Series:: GSE12034
6 Samples

Download data: CEL

DataSet

Accession:: GDS3256

ID:: 3256

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20008044219.

Complement protein C1q modulates macrophage molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins

(Submitter supplied) C1q suppresses JAK-STAT signal transduction and activates PPAR-mediated transcription in macrophages during clearance of modified forms of LDL leading to a reduction in inflammatory response.