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Links from GEO DataSets

Items: 20

1.

Reconstructing aspects of human embryogenesis with pluripotent stem cells

(Submitter supplied) We have established an in vitro model that reconstructs aspects of human embryogensis using human expanded potential pluripotent stem cells (hEPSCs). We performed single-cell RNA sequencing (scRNA-seq) on hEPSCs grown in 2D (prior to aggregation), hEP-structures at day 5, hEP-structures grown in IVC for 24h, and natural human blastocysts at day 5/6.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
2 Samples
Download data: CSV, MTX, TSV
Series
Accession:
GSE178326
ID:
200178326
2.

Generation of blastocyst-like structures from human embryonic stem cells III [scRNA-seq]

(Submitter supplied) We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: CSV
Series
Accession:
GSE163445
ID:
200163445
3.

Generation of blastocyst-like structures from human embryonic stem cells II [scRNA-seq]

(Submitter supplied) We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: CSV
Series
Accession:
GSE163423
ID:
200163423
4.

Generation of blastocyst-like structures from human embryonic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
9 Samples
Download data: CSV
Series
Accession:
GSE150578
ID:
200150578
5.

Generation of blastocyst-like structures from human embryonic stem cells I [scRNA-seq]

(Submitter supplied) We established a method that enables the generation of blastocyst-like structures from human pluripotent stem cells.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
1 Sample
Download data: CSV
Series
Accession:
GSE150570
ID:
200150570
6.

Single Cell RNA-seq analysis of gene expression patterns of cells from stem-cell-derived-synthetic-blastocysts, called as 'ES-' or 'EPS-blastoids'.

(Submitter supplied) To test the efficacy of stem cell lines to generate 'stem-cell-derived-synthetic blastocysts', we dissociated ES- (built by conventional embryonic stem cells and trophoblast stem cells) or EPS-blastoids (built by extended potential pluripotent stem cells and trophoblast stem cells) into single cells following 96h of culture for single-cell transcriptome analysis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
1 Sample
Download data: MTX, TSV, TXT
Series
Accession:
GSE134240
ID:
200134240
7.

Formative transition of human naïve pluripotent stem cells

(Submitter supplied) Human naïve pluripotent stem cells (PSC) share features with pre-implantation epiblast. They thus provide an unmatched opportunity for characterising the developmental programme of pluripotency in Homo sapiens. Here we confirm that naïve PSC do not respond directly to germ layer induction, but must first acquire competence. Capacitation for multi-lineage differentiation occurs without exogenous growth factor stimulation and is facilitated by inhibition of Wnt signalling. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
51 Samples
Download data: TXT
8.

A developmental coordinate of the spectrum of pluripotency among mice, monkeys, and humans

(Submitter supplied) The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of the spectrum of pluripotent stem cells (PSCs) in vitro. To explore the ontogeny of human/primate pluripotency, we performed comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys. Here we show that after specification in the blastocysts [embryonic day (E)7], cyEPI undergoes major transcriptome changes upon implantation. more...
Organism:
Macaca fascicularis; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19944 GPL15907
492 Samples
Download data: TXT
Series
Accession:
GSE74767
ID:
200074767
9.

Hypoblast from human pluripotent stem cells regulates epiblast development [RNA-seq]

(Submitter supplied) Recently, several studies using cultures of human embryos together with single-cell RNA-seq (scRNA-seq) analyses have revealed differences between humans and mice, necessitating the study of human embryos 1-8. Despite the importance of human embryology, ethical and legal restrictions have limited post-implantation stage studies. Thus, recent efforts have focused on developing in vitro self-organising models using human stem cells 9-18. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
33 Samples
Download data: TXT
Series
Accession:
GSE233959
ID:
200233959
10.

Hypoblast from human pluripotent stem cells regulates epiblast development [scRNA-seq]

(Submitter supplied) Recently, several studies using cultures of human embryos together with single-cell RNA-seq (scRNA-seq) analyses have revealed differences between humans and mice, necessitating the study of human embryos. Despite the importance of human embryology, ethical and legal restrictions have limited post-implantation stage studies. Thus, recent efforts have focused on developing in vitro self-organising models using human stem cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL30173 GPL24676
262 Samples
Download data: TXT
Series
Accession:
GSE233715
ID:
200233715
11.

Hypoblast from human pluripotent stem cells regulates epiblast development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL18573 GPL30173
295 Samples
Download data: TXT
Series
Accession:
GSE131747
ID:
200131747
12.

Modelling human pre-gastulation development by 3D culture of blastoids generated from the primed-to-naive transitioning intermediates

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
9 Samples
Download data: TAB
Series
Accession:
GSE200935
ID:
200200935
13.

Modelling human pre-gastulation development by 3D culture of blastoids generated from the primed-to-naive transitioning intermediates [scRNA-seq]

(Submitter supplied) Our study provides an alternative strategy to generate human blastoids and model early embryogenesis up to pre-gastrulation stage, facilitating the insights into human embryonic development
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
1 Sample
Download data: TAB
Series
Accession:
GSE200934
ID:
200200934
14.

Modelling human pre-gastulation development by 3D culture of blastoids generated from the primed-to-naive transitioning intermediates [RNA-seq]

(Submitter supplied) Our study provides an alternative strategy to generate human blastoids and model early embryogenesis up to pre-gastrulation stage, facilitating the insights into human embryonic development
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: TXT
Series
Accession:
GSE200933
ID:
200200933
15.

Single-Cell RNA-seq Defines the Three Cell Lineages of the Human Blastocyst

(Submitter supplied) Here we provide fundamental insights into early human development by single-cell RNA-sequencing of human and mouse preimplantation embryos. We elucidate conserved transcriptional programs along with those that are human-specific. Importantly, we validate our RNA-sequencing findings at the protein level, which further reveals differences in human and mouse embryo gene expression. For example, we identify several genes exclusively expressed in the human pluripotent epiblast including the transcription factor KLF17. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
30 Samples
Download data: TXT
Series
Accession:
GSE66507
ID:
200066507
16.

Conversion of mES to cXEN cells

(Submitter supplied) The inner cell mass of the mouse pre-implantation blastocyst is comprised of epiblast progenitor and primitive endoderm cells of which cognate embryonic (mESCs) or extra-embryonic (XEN) stem cell lines can be derived. Importantly, each stem cell type retains the defining properties and lineage restriction of their in vivo tissue of origin. Recently, we demonstrated that XEN-like cells arise within mESC cultures. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
8 Samples
Download data: TXT
Series
Accession:
GSE38477
ID:
200038477
17.

Capturing totipotency in human cells through spliceosomal repression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20795
112 Samples
Download data: BW, NARROWPEAK, TXT
Series
Accession:
GSE226231
ID:
200226231
18.

Capturing totipotency in human cells through spliceosomal repression [ATAC-seq]

(Submitter supplied) Supplemented with splicing inhibitor PlaB, we realize in vitro culturing of human totipotent stem cells comparable to 2-4-cell blastomeres Assay for transposase accessible chromatin with high-throughput sequencing in hESC sand hTBLCs
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20795
2 Samples
Download data: NARROWPEAK
Series
Accession:
GSE226229
ID:
200226229
19.

Capturing totipotency in human cells through spliceosomal repression [scRNA-seq]

(Submitter supplied) Supplemented with splicing inhibitor PlaB, we realize in vitro culturing of human totipotent stem cells comparable to 2-4-cell blastomeres
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20795
14 Samples
Download data: TXT
Series
Accession:
GSE226228
ID:
200226228
20.

Capturing totipotency in human cells through spliceosomal repression [ChIP-seq]

(Submitter supplied) Supplemented with splicing inhibitor PlaB, we realize in vitro culturing of human totipotent stem cells comparable to 2-4-cell blastomeres Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for h3k4me3 and h3k27me3 in hESC sand hTBLCs
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20795
4 Samples
Download data: BW
Series
Accession:
GSE226227
ID:
200226227
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