GEO DataSets

Analysis of PBMCs from children (2-18 years) with newly diagnosed type 1 or 2 diabetes (T1D or T2D). One and 4 month samples were obtained from 20 of the T1D patients. Results provide insight into molecular mechanisms that distinguish T1D and T2D and those that are common to both forms of diabetes.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state, 2 gender, 4 time sets

Platform:

GPL96

Series:

GSE9006

117 Samples

Download data: CEL

(Submitter supplied) Objective: We hypothesized that type 1 diabetes (T1D) is accompanied by changes in gene expression in peripheral blood mononuclear cells (PBMCs) due to dysregulation of adaptive and innate immunity, counterregulatory responses to immune dysregulation, insulin deficiency and hyperglycemia. Research Design and Methods: Microarray analysis was performed on PBMCs from 43 patients with newly diagnosed T1D, 12 patients with newly diagnosed type 2 diabetes (T2D) and 24 healthy controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3874 GDS3875

Platforms:

GPL96 GPL97

234 Samples

Download data: CEL

Analysis of PBMCs from children (2-18 years) with newly diagnosed type 1 or 2 diabetes (T1D or T2D). One and 4 month samples were obtained from 20 of the T1D patients. Results provide insight into molecular mechanisms that distinguish T1D and T2D and those that are common to both forms of diabetes.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state, 2 gender, 4 time sets

Platform:

GPL97

Series:

GSE9006

117 Samples

Download data: CEL

(Submitter supplied) Type 1 diabetes mellitus (T1D) is a common autoimmune disease mediated by autoimmune attack against pancreatic b cells.Dys-regualtion of the component of peripheral blood mononuclear cells (PBMCs), including T-cells and B-cells, and smaller amounts of NK cells and dendritic cells, have all been implicated in this process This study sought to identify T1D associated differently expressed genes in the peripheral blood mononuclear cell (PBMC).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

22 Samples

Download data: CEL

(Submitter supplied) Type 1 Diabetes (T1D) is considered to be a Th1 autoimmune disease characterised by an absolute lack of insulin caused by an autoimmune destruction of the insulin producing pancreatic beta cells. Th1 lymphocytes are responsible for the infiltration of the islets of Langerhans and for the cytokine release that supports cytotoxic (Tc) lymphocytes to mediate destruction of the beta cells. The preclinical disease stage is characterized by the generation of the self-reactive lymphocytes that infiltrate the pancreas and selectively destroy the insulin-producing beta cells present in the islets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13507

29 Samples

Download data: GPR

(Submitter supplied) The complex milieu of inflammatory mediators associated with many diseases is often too dilute to directly measure in the periphery, necessitating development of more sensitive measurements suitable for mechanistic studies, earlier diagnosis, guiding selection of therapy, and monitoring interventions. Previously, we determined that plasma of recent-onset (RO) Type 1 diabetes (T1D) patients induce a proinflammatory transcriptional signature in fresh peripheral blood mononuclear cells (PBMC) relative to that of unrelated healthy controls (HC). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

286 Samples

Download data: CEL

(Submitter supplied) The complex milieu of inflammatory mediators associated with many diseases is often too dilute to directly measure in the periphery, necessitating development of more sensitive measurements suitable for mechanistic studies, earlier diagnosis, guiding selection of therapy, and monitoring interventions. Previously, we determined that plasma of recent-onset (RO) Type 1 diabetes (T1D) patients induce a proinflammatory transcriptional signature in fresh peripheral blood mononuclear cells (PBMC) relative to that of unrelated healthy controls (HC). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

114 Samples

Download data: CEL

(Submitter supplied) One of the top priorities of the swine industry worldwide is to decrease the susceptibility of its animals to infectious diseases. There is therefore now an increased focus on the production of more “robust” animals, which have lower susceptibility to a broad range of infectious diseases. One general measure of immune competence is the proliferative response of peripheral blood mononuclear cells (PBMC) to mitogenic stimulation. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL14897

24 Samples

Download data: GPR

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approaches that can improveβcell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved.We applied AHST to nine T1D patients diagnosed within six months and analyzed the acute response in peripheral blood genomic expression profiling at the six-month follow-up.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

18 Samples

Download data: CEL

(Submitter supplied) To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13667

356 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Due to privacy concerns, the SNP data is not available with unrestricted access.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6947 GPL13667 GPL6102

724 Samples

Download data: CEL

(Submitter supplied) To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

247 Samples

Download data: TXT

(Submitter supplied) To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

58 Samples

Download data: TXT

(Submitter supplied) To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

63 Samples

Download data: TXT

(Submitter supplied) We compared PBMC genomic response to exercise in both early (EB) and late-pubertal boys (LB) Keywords: stress response

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

40 Samples

Download data: CEL

(Submitter supplied) Skeletal myocytes are metabolically active and susceptible to insulin resistance, thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes and their elucidation at the systems level requires genome-wide data and biological networks. Genome-scale metabolic models (GEMs) provide a network-context to integrate high-throughput data. We generated myocyte-specific RNA-seq data and investigated their correlation with proteome data. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL11154

6 Samples

Download data: TXT