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    unc-40 Netrin receptor unc-40 [ Caenorhabditis elegans ]

    Gene ID: 172233, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-40
    Official Full Name
    Netrin receptor unc-40
    Primary source
    WormBase:WBGene00006776
    Locus tag
    CELE_T19B4.7
    See related
    AllianceGenome:WB:WBGene00006776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables netrin receptor activity and protein domain specific binding activity. Involved in several processes, including nematode male tail tip morphogenesis; nervous system development; and regulation of neuron projection development. Acts upstream of or within dendrite morphogenesis and distal tip cell migration. Located in axonal growth cone and cell projection membrane. Part of receptor complex. Is expressed in several structures, including hermaphrodite somatic gonadal cell; motor neurons; neuroblasts; somatic nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor) and NEO1 (neogenin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-40 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (5679837..5691503, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Mitochondrial import inner membrane translocase subunit TIM14 Neighboring gene Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase Neighboring gene RanBP2-type domain-containing protein Neighboring gene putative peptidylglycine alpha-hydroxylating monooxygenase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables netrin receptor activity PubMed 
    enables netrin receptor activity PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in axon midline choice point recognition PubMed 
    involved_in cell projection morphogenesis PubMed 
    involved_in cell projection morphogenesis PubMed 
    involved_in cell-cell adhesion  
    involved_in chemorepulsion of axon PubMed 
    acts_upstream_of_or_within dendrite morphogenesis PubMed 
    involved_in determination of left/right asymmetry in nervous system PubMed 
    involved_in determination of left/right asymmetry in nervous system PubMed 
    acts_upstream_of_or_within distal tip cell migration PubMed 
    involved_in dorsal/ventral axon guidance PubMed 
    involved_in dorsal/ventral axon guidance PubMed 
    involved_in gonad morphogenesis PubMed 
    involved_in motor neuron axon guidance PubMed 
    involved_in motor neuron axon guidance PubMed 
    involved_in negative regulation of axon extension involved in axon guidance PubMed 
    involved_in negative regulation of sensory neuron axon guidance PubMed 
    involved_in nematode male tail tip morphogenesis PubMed 
    involved_in nervous system development  
    involved_in netrin-activated signaling pathway PubMed 
    involved_in netrin-activated signaling pathway PubMed 
    involved_in neuroblast migration PubMed 
    involved_in neuroblast migration PubMed 
    involved_in neuron migration  
    involved_in neuron migration PubMed 
    involved_in neuron projection development PubMed 
    involved_in positive regulation of BMP signaling pathway PubMed 
    involved_in positive regulation of locomotion PubMed 
    involved_in positive regulation of multicellular organism growth PubMed 
    involved_in positive regulation of synapse assembly PubMed 
    involved_in regulation of cell migration PubMed 
    involved_in regulation of cell migration PubMed 
    involved_in regulation of dorsal/ventral axon guidance PubMed 
    involved_in regulation of dorsal/ventral axon guidance PubMed 
    involved_in regulation of mesodermal cell fate specification PubMed 
    involved_in regulation of motor neuron axon guidance PubMed 
    involved_in sensory neuron axon guidance PubMed 
    involved_in sensory neuron axon guidance PubMed 
    involved_in system development  
    Items 1 - 25 of 39
    Component Evidence Code Pubs
    is_active_in axonal growth cone  
    located_in axonal growth cone PubMed 
    located_in cell projection membrane PubMed 
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of receptor complex PubMed 

    General protein information

    Preferred Names
    Netrin receptor unc-40
    NP_491664.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5679837..5691503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059263.10 → NP_491664.1  Netrin receptor unc-40 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EF96
      Conserved Domains (5) summary
      smart00060
      Location:852 → 927
      FN3; Fibronectin type 3 domain
      smart00410
      Location:251 → 332
      IG_like; Immunoglobulin like
      cd00063
      Location:635 → 727
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:344 → 348
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:341 → 422
      Ig; Immunoglobulin domain
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