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    NUP57 FG-nucleoporin NUP57 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853016, updated on 9-Dec-2024

    Summary

    Official Symbol
    NUP57
    Official Full Name
    FG-nucleoporin NUP57
    Primary source
    SGD:S000003351
    Locus tag
    YGR119C
    See related
    AllianceGenome:SGD:S000003351; FungiDB:YGR119C; VEuPathDB:YGR119C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of nuclear pore. Involved in NLS-bearing protein import into nucleus; nuclear pore organization; and protein localization to nuclear inner membrane. Part of nuclear pore central transport channel. Human ortholog(s) of this gene implicated in dystonia 37, early-onset with striatal lesions. Orthologous to human NUP54 (nucleoporin 54). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See NUP57 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (728046..729671, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S23A Neighboring gene Golgi transport complex subunit COG2 Neighboring gene tRNA-Asn

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus  
    involved_in NLS-bearing protein import into nucleus PubMed 
    involved_in mRNA transport  
    involved_in nuclear pore organization  
    involved_in nuclear pore organization PubMed 
    involved_in protein import into nucleus  
    involved_in protein import into nucleus PubMed 
    involved_in protein localization to nuclear inner membrane  
    involved_in protein localization to nuclear inner membrane PubMed 
    involved_in protein transport  
    Component Evidence Code Pubs
    located_in membrane  
    located_in nuclear membrane  
    part_of nuclear pore PubMed 
    part_of nuclear pore  
    part_of nuclear pore central transport channel  
    part_of nuclear pore central transport channel PubMed 
    part_of nuclear pore central transport channel  
    located_in nucleus  

    General protein information

    Preferred Names
    FG-nucleoporin NUP57
    NP_011634.1
    • FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      728046..729671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181248.1 → NP_011634.1  TPA: FG-nucleoporin NUP57 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011634.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ0, P48837
      UniProtKB/TrEMBL
      A6ZUD2, B5VJ65, N1P3P6
      Conserved Domains (2) summary
      pfam13874
      Location:326 → 462
      Nup54; Nucleoporin complex subunit 54
      pfam15967
      Location:19 → 237
      Nucleoporin_FG2; Nucleoporin FG repeated region
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