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    VPS34 phosphatidylinositol 3-kinase VPS34 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850941, updated on 9-Dec-2024

    Summary

    Official Symbol
    VPS34
    Official Full Name
    phosphatidylinositol 3-kinase VPS34
    Primary source
    SGD:S000004230
    Locus tag
    YLR240W
    See related
    AllianceGenome:SGD:S000004230; FungiDB:YLR240W; VEuPathDB:YLR240W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    END12; PEP15; STT8; VPL7; VPS7; VPT29
    Summary
    Enables 1-phosphatidylinositol-3-kinase activity and protein kinase activity. Involved in several processes, including cellular response to potassium ion starvation; pexophagy; and positive regulation of transcription elongation by RNA polymerase II. Located in several cellular components, including fungal-type vacuole membrane; nucleus-vacuole junction; and phagophore assembly site. Part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Used to study Parkinson's disease. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See VPS34 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (617533..620160)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Far10p Neighboring gene lipoyl(octanoyl) transferase LIP2 Neighboring gene Csc1p Neighboring gene sterol homeostasis protein ARV1

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in autophagosome assembly  
    involved_in autophagy  
    involved_in cellular response to potassium ion starvation PubMed 
    involved_in cellular response to stress  
    involved_in endocytosis  
    involved_in macroautophagy PubMed 
    involved_in pexophagy  
    involved_in pexophagy PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process  
    involved_in phosphatidylinositol phosphate biosynthetic process PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process  
    involved_in phosphatidylinositol-mediated signaling  
    involved_in positive regulation of transcription elongation by RNA polymerase II PubMed 
    involved_in protein transport  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in endosome  
    located_in endosome PubMed 
    located_in endosome  
    located_in endosome membrane  
    located_in fungal-type vacuole membrane PubMed 
    located_in fungal-type vacuole membrane PubMed 
    is_active_in membrane  
    located_in membrane  
    located_in nucleus-vacuole junction PubMed 
    is_active_in peroxisome  
    located_in peroxisome PubMed 
    is_active_in phagophore assembly site  
    located_in phagophore assembly site PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type I  
    part_of phosphatidylinositol 3-kinase complex, class III, type I PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II  
    part_of phosphatidylinositol 3-kinase complex, class III, type II PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol 3-kinase VPS34
    NP_013341.1
    • Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      617533..620160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182127.1 → NP_013341.1  TPA: phosphatidylinositol 3-kinase VPS34 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYN8, P22543
      UniProtKB/TrEMBL
      A7A1C3, B3RHC5, B5VNF7, C7GQZ6, C8ZDK3, G2WJ66, N1P6X3
      Conserved Domains (2) summary
      COG5032
      Location:1 → 872
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd00896
      Location:528 → 871
      PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase
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