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    APC5 anaphase promoting complex subunit 5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854423, updated on 4-Jan-2025

    Summary

    Official Symbol
    APC5
    Official Full Name
    anaphase promoting complex subunit 5
    Primary source
    SGD:S000005775
    Locus tag
    YOR249C
    See related
    AllianceGenome:SGD:S000005775; FungiDB:YOR249C; VEuPathDB:YOR249C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RMC1
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process; chromatin organization; and protein ubiquitination. Located in nucleus. Part of anaphase-promoting complex. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See APC5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (798674..800731, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Env9p Neighboring gene Srl1p Neighboring gene cleavage polyadenylation factor subunit CLP1 Neighboring gene thiosulfate sulfurtransferase

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_001147.6

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    part_of anaphase-promoting complex  
    part_of anaphase-promoting complex PubMed 
    part_of anaphase-promoting complex  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    anaphase promoting complex subunit 5
    NP_014892.3
    • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      798674..800731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183668.3 → NP_014892.3  TPA: anaphase promoting complex subunit 5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014892.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2V0, Q08683
      UniProtKB/TrEMBL
      C7GWE0, N1NYR5
      Conserved Domains (2) summary
      sd00016
      Location:296 → 330
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:302 → 390
      ANAPC5; Anaphase-promoting complex subunit 5
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