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    SMF2 divalent metal ion transporter SMF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856447, updated on 4-Jan-2025

    Summary

    Official Symbol
    SMF2
    Official Full Name
    divalent metal ion transporter SMF2
    Primary source
    SGD:S000001092
    Locus tag
    YHR050W
    See related
    AllianceGenome:SGD:S000001092; FungiDB:YHR050W; VEuPathDB:YHR050W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables inorganic cation transmembrane transporter activity. Involved in intracellular monoatomic cation homeostasis and transition metal ion transport. Located in late endosome and trans-Golgi network. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See SMF2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (207654..209303)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Yhk8p Neighboring gene putative serine hydrolase Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit VI

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport  
    involved_in cobalt ion transport PubMed 
    involved_in intracellular cobalt ion homeostasis PubMed 
    involved_in intracellular manganese ion homeostasis  
    involved_in intracellular manganese ion homeostasis PubMed 
    involved_in iron ion transmembrane transport  
    involved_in manganese ion transmembrane transport  
    involved_in manganese ion transport  
    involved_in manganese ion transport PubMed 
    involved_in metal ion transport  
    Component Evidence Code Pubs
    located_in late endosome PubMed 
    located_in membrane  
    located_in mitochondrion PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in trans-Golgi network PubMed 
    located_in vacuolar lumen  
    located_in vacuole  
    located_in vesicle  

    General protein information

    Preferred Names
    divalent metal ion transporter SMF2
    NP_011917.1
    • Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      207654..209303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179180.1 → NP_011917.1  TPA: divalent metal ion transporter SMF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKZ8, P38778
      UniProtKB/TrEMBL
      A6ZSV7, B5VJY1, G2WFC3, N1P576
      Conserved Domains (1) summary
      TIGR01197
      Location:55 → 458
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
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