U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    POL3 DNA-directed DNA polymerase delta POL3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851456, updated on 9-Dec-2024

    Summary

    Official Symbol
    POL3
    Official Full Name
    DNA-directed DNA polymerase delta POL3
    Primary source
    SGD:S000002260
    Locus tag
    YDL102W
    See related
    AllianceGenome:SGD:S000002260; FungiDB:YDL102W; VEuPathDB:YDL102W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC2; HPR6; TEX1
    Summary
    Enables 3'-5'-DNA exonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA metabolic process. Located in replication fork. Used to study colorectal cancer and endometrial cancer. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POL3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (276872..280165)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative N(6)-L-threonylcarbamoyladenine synthase Neighboring gene UDP-N-acetylglucosamine diphosphorylase Neighboring gene serine/threonine protein kinase DUN1 Neighboring gene guanine nucleotide exchange factor GET3

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity  
    enables 3'-5'-DNA exonuclease activity PubMed 
    enables 4 iron, 4 sulfur cluster binding  
    enables DNA binding  
    enables DNA polymerase activity  
    enables DNA-directed DNA polymerase activity  
    enables DNA-directed DNA polymerase activity PubMed 
    enables DNA-directed DNA polymerase activity  
    enables DNA-directed DNA polymerase activity PubMed 
    enables exonuclease activity  
    enables metal ion binding  
    enables nucleotide binding  
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex  
    part_of delta DNA polymerase complex PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in nucleus  
    located_in replication fork PubMed 

    General protein information

    Preferred Names
    DNA-directed DNA polymerase delta POL3
    NP_010181.2
    • Catalytic subunit of DNA polymerase delta; responsible for most of lagging strand DNA synthesis; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      276872..280165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180161.2 → NP_010181.2  TPA: DNA-directed DNA polymerase delta POL3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010181.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRP8, P15436
      UniProtKB/TrEMBL
      A6ZXM7, C8Z6K2
      Conserved Domains (1) summary
      PTZ00166
      Location:90 → 1095
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    External link. Please review our privacy policy.