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    PEP1 type I sorting receptor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852264, updated on 9-Dec-2024

    Summary

    Official Symbol
    PEP1
    Official Full Name
    type I sorting receptor
    Primary source
    SGD:S000000113
    Locus tag
    YBL017C
    See related
    AllianceGenome:SGD:S000000113; FungiDB:YBL017C; VEuPathDB:YBL017C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPS10; VPT1
    Summary
    Enables signal sequence binding activity. Involved in mitophagy; pexophagy; and protein targeting to vacuole. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See PEP1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (186844..191583, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN2 Neighboring gene ribonuclease P Neighboring gene mitogen-activated serine/threonine-protein kinase FUS3 Neighboring gene acetyl-CoA hydrolase

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleotide binding  
    enables signal sequence binding PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport  
    involved_in Golgi to vacuole transport  
    involved_in mitophagy PubMed 
    involved_in pexophagy PubMed 
    involved_in protein targeting to vacuole  
    involved_in protein targeting to vacuole PubMed 
    involved_in protein transport  
    involved_in vacuolar transport  
    involved_in vacuolar transport PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    located_in cytosol  
    located_in fungal-type vacuole PubMed 
    is_active_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    type I sorting receptor
    NP_009536.1
    • Type I transmembrane sorting receptor for multiple vacuolar hydrolases; plays role in post-ER quality control in the Golgi, involved in protein targeting from the endoplasmic reticulum to the vacuole for degradation; cycles between late-Golgi and prevacuolar endosome-like compartments; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      186844..191583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178257.1 → NP_009536.1  TPA: type I sorting receptor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZKT1, D6VPY3, P32319
      UniProtKB/TrEMBL
      N1P9R4
      Conserved Domains (1) summary
      smart00602
      Location:752 → 1379
      VPS10; VPS10 domain
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