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    WHI3 mRNA-binding protein WHI3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855524, updated on 9-Dec-2024

    Summary

    Official Symbol
    WHI3
    Official Full Name
    mRNA-binding protein WHI3
    Primary source
    SGD:S000005141
    Locus tag
    YNL197C
    See related
    AllianceGenome:SGD:S000005141; FungiDB:YNL197C; VEuPathDB:YNL197C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in several processes, including invasive growth in response to glucose limitation; pseudohyphal growth; and traversing start control point of mitotic cell cycle. Located in P-body; cytoplasmic stress granule; and endoplasmic reticulum membrane. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See WHI3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (267608..269593, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene NADHX epimerase Neighboring gene Gcr2p Neighboring gene Slz1p Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA binding  
    enables mRNA binding PubMed 
    enables mRNA binding PubMed 

    General protein information

    Preferred Names
    mRNA-binding protein WHI3
    NP_014202.1
    • RNA binding protein that modulates mRNA stability; regulates cell cycle, sister chromatid cohesion, and stress response genes; modulates stability and translational efficiency of CLN3 mRNA; colocalizes with P-bodies/stress granules to regulate target mRNAs; regulates cell fate and critical cell size for Start passage; regulates ploidy; self-templating mnemon that forms inactive super-assemblies, preventing G1 arrest in mother cells after unsuccessful mating and causing sterility in old cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      267608..269593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183035.1 → NP_014202.1  TPA: mRNA-binding protein WHI3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Z0, P34761
      UniProtKB/TrEMBL
      A6ZRP0, N1NXA0
      Conserved Domains (2) summary
      COG0724
      Location:450 → 648
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12245
      Location:536 → 624
      RRM_scw1_like; RNA recognition motif (RRM) found in yeast cell wall integrity protein scw1 and similar proteins
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