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    MEF1 Mef1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850758, updated on 9-Dec-2024

    Summary

    Official Symbol
    MEF1
    Official Full Name
    Mef1p
    Primary source
    SGD:S000004059
    Locus tag
    YLR069C
    See related
    AllianceGenome:SGD:S000004059; FungiDB:YLR069C; VEuPathDB:YLR069C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Involved in mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MEF1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (271630..273915, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pet309p Neighboring gene Fyv7p Neighboring gene D-xylulose reductase XYL2 Neighboring gene Rgr1p

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables translation elongation factor activity  
    enables translation elongation factor activity  
    enables translation elongation factor activity PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation PubMed 
    involved_in mitochondrial translational elongation  
    involved_in mitochondrial translational elongation  
    involved_in mitochondrial translational elongation PubMed 
    involved_in translation  
    involved_in translational elongation  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    Mef1p
    NP_013170.1
    • Mitochondrial elongation factor involved in translational elongation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      271630..273915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181956.1 → NP_013170.1  TPA: Mef1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY70, P25039, Q6B1Y6, Q99360
      UniProtKB/TrEMBL
      G2WIR1, N1P6E7
      Conserved Domains (1) summary
      COG0480
      Location:68 → 760
      FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]
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