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    BCK1 mitogen-activated protein kinase kinase kinase BCK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853350, updated on 9-Dec-2024

    Summary

    Official Symbol
    BCK1
    Official Full Name
    mitogen-activated protein kinase kinase kinase BCK1
    Primary source
    SGD:S000003631
    Locus tag
    YJL095W
    See related
    AllianceGenome:SGD:S000003631; FungiDB:YJL095W; VEuPathDB:YJL095W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LAS3; SAP3; SLK1; SSP31
    Summary
    Enables MAP kinase kinase kinase activity. Involved in several processes, including intracellular signal transduction; pexophagy; and regulation of fungal-type cell wall organization. Located in cellular bud neck; cytoplasm; and mating projection tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See BCK1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (247255..251691)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase PHS1 Neighboring gene mitochondrial 54S ribosomal protein YmL49 Neighboring gene Kha1p Neighboring gene Tok1p

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein tyrosine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 27

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase BCK1
    NP_012440.1
    • MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      247255..251691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181528.1 → NP_012440.1  TPA: mitogen-activated protein kinase kinase kinase BCK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW89, P32894, Q01389
      UniProtKB/TrEMBL
      B3LQ18, D3UF59
      Conserved Domains (1) summary
      cd06629
      Location:1173 → 1440
      STKc_Bck1_like; Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases
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