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    CLIP-190 Cytoplasmic linker protein 190 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35042, updated on 4-Jan-2025

    Summary

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    Official Symbol
    CLIP-190provided by FlyBase
    Official Full Name
    Cytoplasmic linker protein 190provided by FlyBase
    Primary source
    FLYBASE:FBgn0020503
    Locus tag
    Dmel_CG5020
    See related
    AllianceGenome:FB:FBgn0020503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5020; Clip- 190; clip-190; Clip-190; clip190; Clip190; CLIP190; D-CLIP-19; D-Clip-190; D-CLIP-190; D-CLIP-195; D-CLIP-90; Dmel\CG5020
    Summary
    Enables actin binding activity; microtubule plus-end binding activity; and myosin VI heavy chain binding activity. Involved in cellularization. Located in several cellular components, including axonal growth cone; fusome; and spindle microtubule. Part of microtubule associated complex. Colocalizes with microtubule plus-end. Is expressed in adult head; oocyte; and spermatozoon. Orthologous to several human genes including CLIP1 (CAP-Gly domain containing linker protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See CLIP-190 in Genome Data Viewer
    Location:
    36C7-36C7; 2-53 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17384700..17409698)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17384700..17409698)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Leucine-rich-repeats and calponin homology domain protein Neighboring gene RNA polymerase II subunit J Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos. Lantz VA, et al. J Cell Biol, 1998 Feb 23. PMID 9472041, Free PMC Article
    2. Membrane trafficking and the cytoskeleton: an integrated view. ASCB/EMBO/Dudley Wright Summer Research Conference, Santa Maria Imbaro, Italy, June 26-30, 1999. Sloboda RD. EMBO J, 1999 Oct 15. PMID 10523289, Free PMC Article
    3. The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics. Currie JD, et al. Mol Biol Cell, 2011 Nov. PMID 21965297, Free PMC Article
    4. Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. Slep KC, et al. J Cell Biol, 2005 Feb 14. PMID 15699215, Free PMC Article
    5. Aplip1, the Drosophila homolog of JIP1, regulates myonuclear positioning and muscle stability. Auld AL, et al. J Cell Sci, 2018 Mar 16. PMID 29487176

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila CLIP-190 (and potentially also mouse CLIP-170) does not possess a significant role in the axon growth-promoting microtubule machinery.
      Title: Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system.
    2. These results indicate distinct molecular requirements for CLIP-190 localisation to unattached kinetochores in mitosis and microtubule ends in interphase.
      Title: Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin VI heavy chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic linker protein 190
    Names
    CG5020-PA
    CG5020-PB
    CG5020-PC
    CG5020-PI
    CG5020-PJ
    CG5020-PM
    CG5020-PN
    CG5020-PO
    CG5020-PP
    CG5020-PQ
    CG5020-PR
    CG5020-PS
    CG5020-PT
    CG5020-PV
    CG5020-PW
    CLIP-190-PA
    CLIP-190-PB
    CLIP-190-PC
    CLIP-190-PI
    CLIP-190-PJ
    CLIP-190-PM
    CLIP-190-PN
    CLIP-190-PO
    CLIP-190-PP
    CLIP-190-PQ
    CLIP-190-PR
    CLIP-190-PS
    CLIP-190-PT
    CLIP-190-PV
    CLIP-190-PW
    cytoplasmic linker protein-190

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17384700..17409698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165213.5 → NP_724047.2  cytoplasmic linker protein 190, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJE5
      Related
      FBpp0080528
      Conserved Domains (7) summary
      COG5244
      Location:237 → 814
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:591 → 1327
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:240 → 306
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1174 → 1270
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1667 → 1683
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:1326 → 1540
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:1280 → 1465
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001144361.3 → NP_001137833.2  cytoplasmic linker protein 190, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZW7
      Conserved Domains (1) summary
      pfam01302
      Location:240 → 306
      CAP_GLY; CAP-Gly domain

    3. NM_001382176.1 → NP_001368962.1  cytoplasmic linker protein 190, isoform W [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6F7UQK0
      Conserved Domains (6) summary
      PHA03307
      Location:2 → 118
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:734 → 1591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:546 → 912
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17078
      Location:1502 → 1702
      SHE3; SWI5-dependent HO expression protein 3
      pfam01302
      Location:239 → 306
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1773 → 1789
      CLIP1_ZNF; CLIP1 zinc knuckle

    4. NM_135991.4 → NP_609835.2  cytoplasmic linker protein 190, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44929, Q8INY8, Q8MSD0, Q9VJE5
      Related
      FBpp0080529
      Conserved Domains (7) summary
      COG5244
      Location:237 → 815
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:592 → 1328
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:240 → 306
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1175 → 1271
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1668 → 1684
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:1327 → 1541
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:1281 → 1466
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. NM_001144362.3 → NP_001137834.2  cytoplasmic linker protein 190, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZW8
      Conserved Domains (6) summary
      TIGR04523
      Location:555 → 1291
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:240 → 306
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1138 → 1234
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1631 → 1647
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:1290 → 1504
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:1244 → 1429
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. NM_001169525.2 → NP_001162996.2  cytoplasmic linker protein 190, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHJ9
      Conserved Domains (7) summary
      COG5244
      Location:216 → 793
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:570 → 1306
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:219 → 285
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1153 → 1249
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1646 → 1662
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:1305 → 1519
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:1259 → 1444
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. NM_176058.3 → NP_788072.4  cytoplasmic linker protein 190, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT48
      Conserved Domains (5) summary
      COG5244
      Location:170 → 748
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:525 → 1261
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:173 → 239
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1108 → 1204
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1601 → 1617
      CLIP1_ZNF; CLIP1 zinc knuckle

    8. NM_001273598.1 → NP_001260527.1  cytoplasmic linker protein 190, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG37
      Conserved Domains (4) summary
      TIGR04523
      Location:503 → 1239
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:173 → 239
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1086 → 1182
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1579 → 1595
      CLIP1_ZNF; CLIP1 zinc knuckle

    9. NM_165214.2 → NP_724048.1  cytoplasmic linker protein 190, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJE5
      Related
      FBpp0080530
      Conserved Domains (5) summary
      COG5244
      Location:199 → 777
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:554 → 1290
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:202 → 268
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1137 → 1233
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1630 → 1646
      CLIP1_ZNF; CLIP1 zinc knuckle

    10. NM_001169526.1 → NP_001162997.1  cytoplasmic linker protein 190, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHK0
      Conserved Domains (5) summary
      COG5244
      Location:145 → 723
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:500 → 1236
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:148 → 214
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:1083 → 1179
      TMPIT; TMPIT-like protein
      pfam16641
      Location:1576 → 1592
      CLIP1_ZNF; CLIP1 zinc knuckle

    11. NM_001042901.2 → NP_001036366.2  cytoplasmic linker protein 190, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, Q0E8Q0
      Conserved Domains (1) summary
      pfam01302
      Location:148 → 214
      CAP_GLY; CAP-Gly domain

    12. NM_001273599.1 → NP_001260528.1  cytoplasmic linker protein 190, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, M9PBC9
      Conserved Domains (1) summary
      pfam01302
      Location:148 → 214
      CAP_GLY; CAP-Gly domain

    13. NM_001042902.4 → NP_001036367.2  cytoplasmic linker protein 190, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, Q0E8Q1
      Conserved Domains (1) summary
      pfam01302
      Location:148 → 214
      CAP_GLY; CAP-Gly domain

    14. NM_001299084.1 → NP_001286013.1  cytoplasmic linker protein 190, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, X2JAQ4
      Conserved Domains (1) summary
      pfam01302
      Location:148 → 214
      CAP_GLY; CAP-Gly domain

    15. NM_001273597.1 → NP_001260526.1  cytoplasmic linker protein 190, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBX3, M9PDB4
      Conserved Domains (1) summary
      pfam01302
      Location:202 → 268
      CAP_GLY; CAP-Gly domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6F7UQK0 A0A6F7UQK0
    B7YZW7 B7YZW7
    B7YZW8 B7YZW8
    E1JHJ9 E1JHJ9
    E1JHK0 E1JHK0
    M9PBC9 M9PBC9
    M9PDB4 M9PDB4
    M9PG37 M9PG37
    Q0E8Q0 Q0E8Q0
    Q0E8Q1 Q0E8Q1
    Q7KT48 Q7KT48
    Q9VJE5.1 Q9VJE5
    X2JAQ4 X2JAQ4

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