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    CIN8 kinesin motor protein CIN8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856648, updated on 4-Jan-2025

    Summary

    Official Symbol
    CIN8
    Official Full Name
    kinesin motor protein CIN8
    Primary source
    SGD:S000000787
    Locus tag
    YEL061C
    See related
    AllianceGenome:SGD:S000000787; FungiDB:YEL061C; VEuPathDB:YEL061C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KSL2; SDS15
    Summary
    Enables minus-end-directed microtubule motor activity and plus-end-directed microtubule motor activity. Involved in microtubule depolymerization; regulation of mitotic sister chromatid segregation; and sister chromatid segregation. Located in astral microtubule; kinetochore; and kinetochore microtubule. Used to study breast cancer; colorectal cancer; lung cancer; prostate cancer; and uterine cancer. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See CIN8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (36535..39537, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene arginine permease CAN1 Neighboring gene nitrogen permease regulating protein NPR2 Neighboring gene proteinase B Neighboring gene Som1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables cytoskeletal motor activity  
    enables microtubule binding  
    enables microtubule motor activity  
    enables microtubule motor activity PubMed 
    enables minus-end-directed microtubule motor activity  
    enables minus-end-directed microtubule motor activity PubMed 
    enables minus-end-directed microtubule motor activity PubMed 
    enables plus-end-directed microtubule motor activity  
    enables plus-end-directed microtubule motor activity PubMed 
    Component Evidence Code Pubs
    located_in astral microtubule PubMed 
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in kinetochore PubMed 
    located_in kinetochore microtubule PubMed 
    located_in microtubule  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    is_active_in mitotic spindle  
    is_active_in nucleus  
    located_in spindle  
    is_active_in spindle microtubule  
    located_in spindle microtubule PubMed 

    General protein information

    Preferred Names
    kinesin motor protein CIN8
    NP_010853.2
    • Bipolar kinesin motor protein; switches from minus- to plus-end-directed motility in vitro depending on conditions; involved in mitotic spindle assembly and chromosome segregation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      36535..39537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178876.1 → NP_010853.2  TPA: kinesin motor protein CIN8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010853.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLI9, P27895
      UniProtKB/TrEMBL
      A6ZQP0, B5VH76, C7GXE8, G2WCH3, N1P3E4
      Conserved Domains (3) summary
      COG1196
      Location:493 → 772
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01364
      Location:34 → 486
      KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
      pfam15921
      Location:677 → 928
      CCDC158; Coiled-coil domain-containing protein 158
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