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    anc-1 Calponin-homology (CH) domain-containing protein;KASH domain-containing protein;Nuclear anchorage protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172034, updated on 9-Dec-2024

    Summary

    Official Symbol
    anc-1
    Official Full Name
    Calponin-homology (CH) domain-containing protein;KASH domain-containing protein;Nuclear anchorage protein 1
    Primary source
    WormBase:WBGene00000140
    Locus tag
    CELE_ZK973.6
    See related
    AllianceGenome:WB:WBGene00000140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and kinesin binding activity. Involved in cytoskeleton organization; nucleus organization; and pronuclear migration. Located in nuclear envelope and perinuclear region of cytoplasm. Is expressed in several structures, including body wall musculature. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to several human genes including SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See anc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    31
    Sequence:
    Chromosome: I; NC_003279.8 (4318033..4359092)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nucleotidyl transferase domain-containing protein Neighboring gene ABC transporter permease Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AcetylCholine Receptor Neighboring gene Uncharacterized protein

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding  
    enables actin binding PubMed 
    enables kinesin binding  
    enables protein binding PubMed 
    enables protein-folding chaperone binding  
    Process Evidence Code Pubs
    involved_in cellular localization  
    involved_in cytoskeleton organization  
    involved_in cytoskeleton organization PubMed 
    involved_in localization PubMed 
    involved_in nuclear migration  
    involved_in nucleus localization PubMed 
    involved_in nucleus organization  
    involved_in nucleus organization PubMed 
    involved_in pronuclear migration PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in membrane  
    is_active_in nuclear envelope  
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear outer membrane  
    located_in nucleus  
    is_active_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    Calponin-homology (CH) domain-containing protein;KASH domain-containing protein;Nuclear anchorage protein 1
    NP_001343707.1
    • Confirmed by transcript evidence
    NP_001343735.1
    • Confirmed by transcript evidence
    NP_491353.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4318033..4359092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356817.3 → NP_001343707.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3A7
      Conserved Domains (5) summary
      TIGR04527
      Location:1945 → 2071
      mycoplas_twoTM; two transmembrane protein
      pfam00307
      Location:16 → 124
      CH; Calponin homology (CH) domain
      pfam10541
      Location:8485 → 8537
      KASH; Nuclear envelope localization domain
      cl25732
      Location:5834 → 6670
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:2876 → 3906
      Neuromodulin_N; Gap junction protein N-terminal region
    2. NM_058952.5 → NP_491353.2  Nuclear anchorage protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491353.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61841, O61842, Q6IMP3, Q9N4M4
      Conserved Domains (6) summary
      COG0419
      Location:2272 → 2886
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:6744 → 7580
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04527
      Location:1952 → 2078
      mycoplas_twoTM; two transmembrane protein
      pfam00307
      Location:25 → 125
      CH; Calponin homology (CH) domain
      pfam10541
      Location:8492 → 8544
      KASH; Nuclear envelope localization domain
      cl19511
      Location:7746 → 7866
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
    3. NM_001356818.3 → NP_001343735.1  KASH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2Z1
      Conserved Domains (5) summary
      PTZ00121
      Location:1878 → 2908
      PTZ00121; MAEBL; Provisional
      COG0419
      Location:1269 → 1881
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:5739 → 6575
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04527
      Location:947 → 1073
      mycoplas_twoTM; two transmembrane protein
      pfam10541
      Location:7487 → 7539
      KASH; Nuclear envelope localization domain
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