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    MMS4 Mms4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852395, updated on 9-Dec-2024

    Summary

    Official Symbol
    MMS4
    Official Full Name
    Mms4p
    Primary source
    SGD:S000000302
    Locus tag
    YBR098W
    See related
    AllianceGenome:SGD:S000000302; FungiDB:YBR098W; VEuPathDB:YBR098W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLX2; YBR100W
    Summary
    Contributes to crossover junction DNA endonuclease activity. Involved in DNA metabolic process and regulation of reciprocal meiotic recombination. Part of Holliday junction resolvase complex. Orthologous to human EME1 (essential meiotic structure-specific endonuclease 1) and EME2 (essential meiotic structure-specific endonuclease subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MMS4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (441515..443590)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ubiquitin-binding serine/threonine protein kinase VPS15 Neighboring gene Hsp70 nucleotide exchange factor FES1 Neighboring gene exocyst subunit EXO84

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_001134.8

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding  
    contributes_to DNA endonuclease activity PubMed 
    contributes_to crossover junction DNA endonuclease activity  
    contributes_to crossover junction DNA endonuclease activity PubMed 
    enables endonuclease activity  
    enables metal ion binding  
    enables nuclease activity  
    Process Evidence Code Pubs
    involved_in DNA damage response PubMed 
    involved_in DNA recombination  
    involved_in DNA repair  
    involved_in DNA repair PubMed 
    involved_in DNA topological change PubMed 
    involved_in double-strand break repair  
    involved_in meiosis I cell cycle process  
    involved_in meiotic cell cycle  
    involved_in mitotic intra-S DNA damage checkpoint signaling  
    involved_in reciprocal meiotic recombination PubMed 
    involved_in reciprocal meiotic recombination PubMed 
    involved_in regulation of reciprocal meiotic recombination PubMed 
    involved_in replication fork processing  
    involved_in resolution of meiotic recombination intermediates  
    involved_in resolution of meiotic recombination intermediates PubMed 
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex  
    part_of Holliday junction resolvase complex PubMed 
    part_of Holliday junction resolvase complex  
    located_in nucleus  

    General protein information

    Preferred Names
    Mms4p
    NP_009656.2
    • Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      441515..443590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178446.1 → NP_009656.2  TPA: Mms4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009656.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ99, P38257, P38259, Q6B1Z9, Q9URQ2
      UniProtKB/TrEMBL
      D3UEJ3, G2W9A5, N1P9F9
      Conserved Domains (1) summary
      cd20080
      Location:397 → 599
      XPF_nuclease_EME-like; XPF-like nuclease domain of the family of Essential Meiotic Endonucleases (EMEs) and similar proteins
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