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    BubR1 Bub1-related kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35522, updated on 9-Dec-2024

    Summary

    Official Symbol
    BubR1provided by FlyBase
    Official Full Name
    Bub1-related kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263855
    Locus tag
    Dmel_CG7838
    See related
    AllianceGenome:FB:FBgn0263855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    31/13; BcDNA:LD23835; bub1; Bub1; BUB1; bubr1; bubR1; BUBR1; CG 7838; CG7838; dBUB1; Dmbub1; DmBUB1; DmBubRI; Dmel\CG7838; l(2)k03113; l(2)k06109; mcl(2)Z1525
    Summary
    Predicted to enable protein kinase activity. Involved in several processes, including chromosome organization; heterochromatin formation; and regulation of mitotic cell cycle phase transition. Located in cytoplasm and kinetochore. Is expressed in central brain primordium; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See BubR1 in Genome Data Viewer
    Location:
    42A5-42A6; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5969099..5974385, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1856604..1861890, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44127 Neighboring gene maleless Neighboring gene Src oncogene at 42A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein kinase activity  
    enables protein kinase activity  
    Process Evidence Code Pubs
    involved_in cellular response to starvation PubMed 
    involved_in female meiosis sister chromatid cohesion PubMed 
    involved_in heterochromatin formation PubMed 
    involved_in male meiosis sister chromatid cohesion PubMed 
    involved_in meiotic sister chromatid cohesion, centromeric  
    involved_in meiotic sister chromatid cohesion, centromeric PubMed 
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in mitotic spindle assembly checkpoint signaling PubMed 
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in mitotic spindle assembly checkpoint signaling PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of exit from mitosis PubMed 
    involved_in regulation of exit from mitosis PubMed 
    involved_in regulation of mitotic sister chromatid separation PubMed 
    involved_in synaptonemal complex organization PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in kinetochore  
    located_in kinetochore PubMed 
    is_active_in nucleus  

    General protein information

    Preferred Names
    Bub1-related kinase
    Names
    BubR1-PA
    CG7838-PA
    bub related one

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5969099..5974385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058034.4 → NP_477382.1  Bub1-related kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6I7, Q7KN56
      Related
      FBpp0085368
      Conserved Domains (2) summary
      cd13981
      Location:1174 → 1458
      STKc_Bub1_BubR1; Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1
      pfam08311
      Location:38 → 159
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
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