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    CMK2 calmodulin-dependent protein kinase CMK2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854144, updated on 9-Dec-2024

    Summary

    Official Symbol
    CMK2
    Official Full Name
    calmodulin-dependent protein kinase CMK2
    Primary source
    SGD:S000005376
    Locus tag
    YOL016C
    See related
    AllianceGenome:SGD:S000005376; FungiDB:YOL016C; VEuPathDB:YOL016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to several human genes including CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See CMK2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (294777..296120, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tlg2p Neighboring gene Esc8p Neighboring gene Irc10p Neighboring gene uncharacterized protein

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    calmodulin-dependent protein kinase CMK2
    NP_014626.1
    • Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      294777..296120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183270.1 → NP_014626.1  TPA: calmodulin-dependent protein kinase CMK2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W250, P22517
      UniProtKB/TrEMBL
      A6ZNJ1, B3LJ41, B5VRN9, C7GQW6, C8ZHU8, N1NWD9
      Conserved Domains (2) summary
      smart00220
      Location:47 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05117
      Location:46 → 308
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
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