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    SSA4 Hsp70 family chaperone SSA4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856840, updated on 4-Jan-2025

    Summary

    Official Symbol
    SSA4
    Official Full Name
    Hsp70 family chaperone SSA4
    Primary source
    SGD:S000000905
    Locus tag
    YER103W
    See related
    AllianceGenome:SGD:S000000905; FungiDB:YER103W; VEuPathDB:YER103W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YG107
    Summary
    Enables unfolded protein binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation and protein folding. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See SSA4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (364589..366517)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Ast2p Neighboring gene ribosomal 40S subunit protein S8B Neighboring gene Rtt105p Neighboring gene Nup157p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent protein folding chaperone  
    enables heat shock protein binding  
    enables protein folding chaperone  
    enables unfolded protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    Hsp70 family chaperone SSA4
    NP_011029.3
    • Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; translocates to the nucleus under Cd2+ stress to mediate tolerance by regulating VHS1 expression; cytoplasmic protein that concentrates in nuclei upon starvation; member of the HSP70 family; SSA4 has a paralog, SSA3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      364589..366517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178994.3 → NP_011029.3  TPA: Hsp70 family chaperone SSA4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011029.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM10, P22202
      UniProtKB/TrEMBL
      A6ZR59, B3LRM1, C7GS82, N1P731
      Conserved Domains (1) summary
      PTZ00009
      Location:4 → 642
      PTZ00009; heat shock 70 kDa protein; Provisional
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