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    IPI3 chromatin-binding/pre-rRNA-processing protein IPI3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855539, updated on 9-Dec-2024

    Summary

    Official Symbol
    IPI3
    Official Full Name
    chromatin-binding/pre-rRNA-processing protein IPI3
    Primary source
    SGD:S000005126
    Locus tag
    YNL182C
    See related
    AllianceGenome:SGD:S000005126; FungiDB:YNL182C; VEuPathDB:YNL182C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Involved in pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-templated DNA replication initiation; and ribosome biogenesis. Located in nucleoplasm. Part of nuclear pre-replicative complex and rixosome complex. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See IPI3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (295960..297627, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL19 Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase NPR1 Neighboring gene putative oxidoreductase Neighboring gene Rho family GTPase RHO5

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    part_of nuclear pre-replicative complex  
    part_of nuclear pre-replicative complex PubMed 
    located_in nucleoplasm PubMed 
    located_in nucleus PubMed 
    located_in nucleus  
    part_of rixosome complex  
    part_of rixosome complex PubMed 

    General protein information

    Preferred Names
    chromatin-binding/pre-rRNA-processing protein IPI3
    NP_014217.1
    • Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      295960..297627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183020.1 → NP_014217.1  TPA: chromatin-binding/pre-rRNA-processing protein IPI3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014217.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W104, P53877
      UniProtKB/TrEMBL
      B3LP32, B5VQM6, C7GTF5, C8ZG47, N1NXB1
      Conserved Domains (2) summary
      sd00039
      Location:143 → 187
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:108 → 226
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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