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    unc-16 JNK-interacting protein [ Caenorhabditis elegans ]

    Gene ID: 176349, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-16
    Official Full Name
    JNK-interacting protein
    Primary source
    WormBase:WBGene00006755
    Locus tag
    CELE_ZK1098.10
    See related
    AllianceGenome:WB:WBGene00006755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables kinase binding activity; kinesin binding activity; and signaling adaptor activity. Involved in several processes, including defecation; egg-laying behavior; and regulation of JNK cascade. Located in axon; cell body; and cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to several human genes including MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-16 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    27
    Sequence:
    Chromosome: III; NC_003281.10 (9546258..9557450)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene DUF2975 domain-containing protein Neighboring gene ncRNA Neighboring gene Protein NATD1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables JUN kinase binding  
    enables MAP-kinase scaffold activity  
    enables MAP-kinase scaffold activity PubMed 
    enables MAP-kinase scaffold activity  
    enables kinase binding PubMed 
    enables kinesin binding  
    enables kinesin binding PubMed 
    enables protein binding PubMed 
    enables signaling receptor complex adaptor activity  
    enables signaling receptor complex adaptor activity PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade  
    involved_in defecation PubMed 
    involved_in egg-laying behavior PubMed 
    involved_in locomotion PubMed 
    involved_in regulation of JNK cascade PubMed 
    involved_in sleep PubMed 
    involved_in synaptic vesicle transport PubMed 
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport PubMed 
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in axon initial segment PubMed 
    located_in axon terminus PubMed 
    located_in cell body PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    JNK-interacting protein
    NP_001022981.1
    • Confirmed by transcript evidence
    NP_001122747.1
    • Confirmed by transcript evidence
    NP_001122748.1
    • Confirmed by transcript evidence
    NP_001255008.1
    • Confirmed by transcript evidence
    NP_001255009.1
    • Confirmed by transcript evidence
    NP_001293608.1
    • Confirmed by transcript evidence
    NP_001293609.1
    • Confirmed by transcript evidence
    NP_001293611.1
    • Partially confirmed by transcript evidence
    NP_001293612.1
    • Partially confirmed by transcript evidence
    NP_001293613.1
    • Partially confirmed by transcript evidence
    NP_001293614.1
    • Partially confirmed by transcript evidence
    NP_001293615.1
    • Partially confirmed by transcript evidence
    NP_001293616.1
    • Confirmed by transcript evidence
    NP_001293617.1
    • Confirmed by transcript evidence
    NP_001380131.1
    • Confirmed by transcript evidence
    NP_741263.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9546258..9557450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171221.7 → NP_741263.3  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741263.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34609
      Conserved Domains (4) summary
      pfam03286
      Location:186 → 287
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:6 → 159
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:363 → 417
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:314 → 382
      JIP_LZII; JNK-interacting protein leucine zipper II
    2. NM_001268079.4 → NP_001255008.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255008.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7LPE3, A7LPE4, C0P271, C7FZT6, P34609, Q95V72, S6EZN6, S6EZP3, S6F548, S6F556, S6FD02, S6FN04, S6FN08, S6FWP4, S6FWP6, U4MKU8
      Conserved Domains (4) summary
      COG1196
      Location:75 → 486
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09744
      Location:41 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:365 → 433
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam19056
      Location:788 → 1052
      WD40_2; WD40 repeated domain
    3. NM_001129276.3 → NP_001122748.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPE4
      Conserved Domains (4) summary
      pfam03286
      Location:222 → 402
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:381 → 435
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:332 → 400
      JIP_LZII; JNK-interacting protein leucine zipper II
    4. NM_001027810.5 → NP_001022981.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34609
      Conserved Domains (4) summary
      pfam03286
      Location:222 → 402
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:381 → 435
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:332 → 400
      JIP_LZII; JNK-interacting protein leucine zipper II
    5. NM_001392177.1 → NP_001380131.1  JNK-interacting protein [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam09744
      Location:41 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:414 → 468
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:365 → 420
      JIP_LZII; JNK-interacting protein leucine zipper II
    6. NM_001306680.3 → NP_001293609.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FN04
      Conserved Domains (2) summary
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:338 → 406
      JIP_LZII; JNK-interacting protein leucine zipper II
    7. NM_001306685.3 → NP_001293614.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZP3
      Conserved Domains (3) summary
      pfam03286
      Location:241 → 342
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:402 → 470
      JIP_LZII; JNK-interacting protein leucine zipper II
    8. NM_001306686.3 → NP_001293615.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FN08
      Conserved Domains (2) summary
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:350 → 418
      JIP_LZII; JNK-interacting protein leucine zipper II
    9. NM_001306684.3 → NP_001293613.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FD02
      Conserved Domains (2) summary
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:344 → 412
      JIP_LZII; JNK-interacting protein leucine zipper II
    10. NM_001306682.3 → NP_001293611.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4MKU8
      Conserved Domains (2) summary
      pfam09744
      Location:6 → 159
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:347 → 415
      JIP_LZII; JNK-interacting protein leucine zipper II
    11. NM_001268080.3 → NP_001255009.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7FZT6
      Conserved Domains (2) summary
      pfam15619
      Location:109 → 201
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16471
      Location:83 → 151
      JIP_LZII; JNK-interacting protein leucine zipper II
    12. NM_001306683.3 → NP_001293612.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F548
      Conserved Domains (2) summary
      pfam14075
      Location:183 → 237
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:134 → 202
      JIP_LZII; JNK-interacting protein leucine zipper II
    13. NM_001306687.3 → NP_001293616.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FWP6
      Conserved Domains (2) summary
      pfam15619
      Location:47 → 139
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16471
      Location:21 → 89
      JIP_LZII; JNK-interacting protein leucine zipper II
    14. NM_001306679.3 → NP_001293608.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZN6
      Conserved Domains (2) summary
      pfam15619
      Location:41 → 133
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16471
      Location:15 → 83
      JIP_LZII; JNK-interacting protein leucine zipper II
    15. NM_001306688.3 → NP_001293617.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F556
    16. NM_001129275.4 → NP_001122747.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPE3
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