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    CLIP-190 Cytoplasmic linker protein 190 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35042, updated on 2-Nov-2024

    Summary

    Official Symbol
    CLIP-190provided by FlyBase
    Official Full Name
    Cytoplasmic linker protein 190provided by FlyBase
    Primary source
    FLYBASE:FBgn0020503
    Locus tag
    Dmel_CG5020
    See related
    AllianceGenome:FB:FBgn0020503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5020; Clip- 190; clip-190; Clip-190; clip190; Clip190; CLIP190; D-CLIP-19; D-Clip-190; D-CLIP-190; D-CLIP-195; D-CLIP-90; Dmel\CG5020
    Summary
    Enables actin binding activity; microtubule plus-end binding activity; and myosin VI heavy chain binding activity. Involved in cellularization. Located in several cellular components, including axonal growth cone; fusome; and spindle microtubule. Part of microtubule associated complex. Colocalizes with microtubule plus-end. Is expressed in adult head; oocyte; and spermatozoon. Orthologous to several human genes including CLIP1 (CAP-Gly domain containing linker protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CLIP-190 in Genome Data Viewer
    Location:
    36C7-36C7; 2-53 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17384700..17409698)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17384700..17409698)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Leucine-rich-repeats and calponin homology domain protein Neighboring gene RNA polymerase II subunit J Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 9

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables myosin VI heavy chain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytoplasmic linker protein 190
    Names
    CG5020-PA
    CG5020-PB
    CG5020-PC
    CG5020-PI
    CG5020-PJ
    CG5020-PM
    CG5020-PN
    CG5020-PO
    CG5020-PP
    CG5020-PQ
    CG5020-PR
    CG5020-PS
    CG5020-PT
    CG5020-PV
    CG5020-PW
    CLIP-190-PA
    CLIP-190-PB
    CLIP-190-PC
    CLIP-190-PI
    CLIP-190-PJ
    CLIP-190-PM
    CLIP-190-PN
    CLIP-190-PO
    CLIP-190-PP
    CLIP-190-PQ
    CLIP-190-PR
    CLIP-190-PS
    CLIP-190-PT
    CLIP-190-PV
    CLIP-190-PW
    cytoplasmic linker protein-190

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17384700..17409698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165213.5NP_724047.2  cytoplasmic linker protein 190, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724047.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJE5
      Related
      FBpp0080528
      Conserved Domains (7) summary
      COG5244
      Location:237814
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:5911327
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:240306
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:11741270
      TMPIT; TMPIT-like protein
      pfam16641
      Location:16671683
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:13261540
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:12801465
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001144361.3NP_001137833.2  cytoplasmic linker protein 190, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137833.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZW7
      Conserved Domains (1) summary
      pfam01302
      Location:240306
      CAP_GLY; CAP-Gly domain
    3. NM_001382176.1NP_001368962.1  cytoplasmic linker protein 190, isoform W [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6F7UQK0
      Conserved Domains (6) summary
      PHA03307
      Location:2118
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:7341591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:546912
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17078
      Location:15021702
      SHE3; SWI5-dependent HO expression protein 3
      pfam01302
      Location:239306
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:17731789
      CLIP1_ZNF; CLIP1 zinc knuckle
    4. NM_135991.4NP_609835.2  cytoplasmic linker protein 190, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609835.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44929, Q8INY8, Q8MSD0, Q9VJE5
      Related
      FBpp0080529
      Conserved Domains (7) summary
      COG5244
      Location:237815
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:5921328
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:240306
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:11751271
      TMPIT; TMPIT-like protein
      pfam16641
      Location:16681684
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:13271541
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:12811466
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. NM_001144362.3NP_001137834.2  cytoplasmic linker protein 190, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137834.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZW8
      Conserved Domains (6) summary
      TIGR04523
      Location:5551291
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:240306
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:11381234
      TMPIT; TMPIT-like protein
      pfam16641
      Location:16311647
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:12901504
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:12441429
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. NM_001169525.2NP_001162996.2  cytoplasmic linker protein 190, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162996.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHJ9
      Conserved Domains (7) summary
      COG5244
      Location:216793
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:5701306
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:219285
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:11531249
      TMPIT; TMPIT-like protein
      pfam16641
      Location:16461662
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17078
      Location:13051519
      SHE3; SWI5-dependent HO expression protein 3
      cl12013
      Location:12591444
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    7. NM_176058.3NP_788072.4  cytoplasmic linker protein 190, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788072.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT48
      Conserved Domains (5) summary
      COG5244
      Location:170748
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:5251261
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:173239
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:11081204
      TMPIT; TMPIT-like protein
      pfam16641
      Location:16011617
      CLIP1_ZNF; CLIP1 zinc knuckle
    8. NM_001273598.1NP_001260527.1  cytoplasmic linker protein 190, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG37
      Conserved Domains (4) summary
      TIGR04523
      Location:5031239
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:173239
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:10861182
      TMPIT; TMPIT-like protein
      pfam16641
      Location:15791595
      CLIP1_ZNF; CLIP1 zinc knuckle
    9. NM_165214.2NP_724048.1  cytoplasmic linker protein 190, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJE5
      Related
      FBpp0080530
      Conserved Domains (5) summary
      COG5244
      Location:199777
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:5541290
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:202268
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:11371233
      TMPIT; TMPIT-like protein
      pfam16641
      Location:16301646
      CLIP1_ZNF; CLIP1 zinc knuckle
    10. NM_001169526.1NP_001162997.1  cytoplasmic linker protein 190, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162997.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHK0
      Conserved Domains (5) summary
      COG5244
      Location:145723
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:5001236
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01302
      Location:148214
      CAP_GLY; CAP-Gly domain
      pfam07851
      Location:10831179
      TMPIT; TMPIT-like protein
      pfam16641
      Location:15761592
      CLIP1_ZNF; CLIP1 zinc knuckle
    11. NM_001042901.2NP_001036366.2  cytoplasmic linker protein 190, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036366.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, Q0E8Q0
      Conserved Domains (1) summary
      pfam01302
      Location:148214
      CAP_GLY; CAP-Gly domain
    12. NM_001273599.1NP_001260528.1  cytoplasmic linker protein 190, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, M9PBC9
      Conserved Domains (1) summary
      pfam01302
      Location:148214
      CAP_GLY; CAP-Gly domain
    13. NM_001042902.4NP_001036367.2  cytoplasmic linker protein 190, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036367.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, Q0E8Q1
      Conserved Domains (1) summary
      pfam01302
      Location:148214
      CAP_GLY; CAP-Gly domain
    14. NM_001299084.1NP_001286013.1  cytoplasmic linker protein 190, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286013.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H861, X2JAQ4
      Conserved Domains (1) summary
      pfam01302
      Location:148214
      CAP_GLY; CAP-Gly domain
    15. NM_001273597.1NP_001260526.1  cytoplasmic linker protein 190, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBX3, M9PDB4
      Conserved Domains (1) summary
      pfam01302
      Location:202268
      CAP_GLY; CAP-Gly domain